Results 131 to 140 of about 685,843 (268)

The Role of N-Glycosylation in the Intracellular Trafficking and Functionality of Neuronal Growth Regulator 1. [PDF]

Cells, 2022
Sim G, Jeong M, Seo H, Kim J, Lee S.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Biological agents and plant growth regulator promote rice growth and regenerative capacity. [PDF]

BMC Plant Biol
Zhou H, Liu L, Zhou J, He A, Wu Z.
europepmc   +1 more source

The Transcription Factors WRKY41 and WRKY53 Mediate Early Flowering Induced by the Novel Plant Growth Regulator Guvermectin in Arabidopsis thaliana. [PDF]

Int J Mol Sci, 2023
Yang C, Liu C, Li S, Zhang Y, Zhang Y, Wang X, Xiang W.   +6 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The molecular structure of the master growth regulator in plants emerges into the spotlight. [PDF]

Proc Natl Acad Sci U S A
Yoshida H, Matsuoka M.
europepmc   +1 more source

Epigenetic control of the imprinted growth regulator <i>Cdkn1c</i> in cadmium-induced placental dysfunction. [PDF]

Epigenetics, 2023
Simmers MD, Hudson KM, Baptissart M, Cowley M.   +3 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Regulating hair growth [PDF]

Nature Immunology, 2017
openaire   +2 more sources

Optimizing Growth Regulator Concentrations for <i>Cannabis sativa</i> L. Micropropagation. [PDF]

Plants (Basel)
Johnson GA, Jackson CL, Timoteo A, Sardaru P, Foland MH, Natarajan P, Dhekney SA.   +6 more
europepmc   +1 more source