Results 161 to 170 of about 8,134,109 (313)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Effects of Hot Water and Plant Growth Regulator Treatments on Bud Germination and Pathogen Elimination in Citrus Scions. [PDF]

Plants (Basel)
Zhang Y, Sun L, Xiao J, Chen H, Li N, Li D, Dai S.   +6 more
europepmc   +1 more source

Reduced secretion of neuronal growth regulator 1 contributes to impaired adipose-neuronal crosstalk in obesity. [PDF]

Nat Commun, 2022
Duregotti E, Reumiller CM, Mayr U, Hasman M, Schmidt LE, Burnap SA, Theofilatos K, Barallobre-Barreiro J, Beran A, Grandoch M, Viviano A, Jahangiri M, Mayr M.   +12 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

A new use of Agrobacterium plant growth regulator genes for plant bioengineering. [PDF]

Front Plant Sci
Heck M, Pitino M, Coradetti S, DeBlasio SL, Cooper WR, Shrum L, Harper D, Stallone M, Scott A, Cook R, Rhodes B, Sullivan S, Schechter E, Cochrane E, Larson N, Locatelli G, Hodge J, Grando MF, Wang L, Ariyarante M, Tibebu R, Stange R, Howe KJ, Makar A, Stuehler D, Thompson L, Shende K, Hentz M, Gaza N, Weeks-Purdy C, Chang B, Nikoomanzar A, Bennett L, Demirden N, Hunter W, Thomson J, Ritenour MA, Rossi L, Cano LM, Adair RC, Stover E, McKenzie CL, Niedz R, Shatters RG.   +43 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Multi-level assessment of chronic toxicity of the insect growth regulator lufenuron in the non-target aquatic organism Daphnia magna. [PDF]

Environ Geochem Health
Dane H, Aksakal Ö, Şişman T, Gür C, Alat Ö.   +4 more
europepmc   +1 more source

The Role of N-Glycosylation in the Intracellular Trafficking and Functionality of Neuronal Growth Regulator 1. [PDF]

Cells, 2022
Sim G, Jeong M, Seo H, Kim J, Lee S.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Biological agents and plant growth regulator promote rice growth and regenerative capacity. [PDF]

BMC Plant Biol
Zhou H, Liu L, Zhou J, He A, Wu Z.
europepmc   +1 more source