Results 191 to 200 of about 8,134,109 (313)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

<i>LvSlc12A2</i> Is a Negative Growth Regulator in Whiteleg Shrimp, <i>Litopenaeus vannamei</i>. [PDF]

Animals (Basel)
Niu P, Jiang S, Liu M, Chen S, Kong J, Luan S, Meng X, Xing Q, Zeng Q, Luo K, Gao H.   +10 more
europepmc   +1 more source

Multi-omics approaches explain the growth-promoting effect of the apocarotenoid growth regulator zaxinone in rice. [PDF]

Commun Biol, 2021
Wang JY, Alseekh S, Xiao T, Ablazov A, Perez de Souza L, Fiorilli V, Anggarani M, Lin PY, Votta C, Novero M, Jamil M, Lanfranco L, Hsing YC, Blilou I, Fernie AR, Al-Babili S.   +15 more
europepmc   +1 more source

Transforming Growth Factor-β: Master Regulator of the Respiratory System in Health and Disease.

American Journal of Respiratory Cell and Molecular Biology, 2016
Y. Aschner, G. Downey
semanticscholar   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Susceptibility of the invasive malaria vector Anopheles stephensi in Ethiopia to novel chemical insecticides and insect growth regulator. [PDF]

Sci Rep
Abiy E, Degefa T, Balkew M, Merga H, Alemayehu E, Mitiku A, Lee MC, Yan G, Yewhalaw D.   +8 more
europepmc   +1 more source

Integrated Transcriptomic and Metabolomic Analysis of the Mechanism of Foliar Application of Hormone-Type Growth Regulator in the Improvement of Grape (Vitis vinifera L.) Coloration in Saline-Alkaline Soil. [PDF]

Plants (Basel), 2022
Chang D, Liu H, An M, Hong D, Fan H, Wang K, Li Z.   +6 more
europepmc   +1 more source

MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes.

Cell, 1998
Thiennu H. Vu, J. Shipley, G. Bergers, Joel E. Berger, J. Helms, D. Hanahan, Steven D. Shapiro, Robert M. Senior, Z. Werb   +8 more
semanticscholar   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Effects of plant growth regulator (2,4-D) treatments on fruit development and chemical content in the kiwifruit plant (Actinidia chinensis). [PDF]

BMC Plant Biol
Wu L, Dong J, Zheng H, Wang Y, Qiu D, Atak A, Zhang Q, Zhong C.   +7 more
europepmc   +1 more source