Results 111 to 120 of about 8,293,286 (354)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Profiling of 1-aminocyclopropane-1-carboxylic acid and selected phytohormones in Arabidopsis using liquid chromatography-tandem mass spectrometry

Plant Methods
Background Gaseous phytohormone ethylene levels are directly influenced by the production of its immediate non-volatile precursor 1-aminocyclopropane-1-carboxylic acid (ACC).
Michal Karady, Pavel Hladík, Kateřina Cermanová, Petra Jiroutová, Ioanna Antoniadi, Rubén Casanova-Sáez, Karin Ljung, Ondřej Novák   +7 more
doaj   +1 more source

Mal de Río Cuarto virus infection causes hormone imbalance and sugar accumulation in wheat leaves

BMC Plant Biology, 2019
Background Mal de Río Cuarto virus (MRCV) infects several monocotyledonous species including maize and wheat. Infected plants show shortened internodes, partial sterility, increased tillering and reduced root length.
Luis Alejandro de Haro, Sofía Maité Arellano, Ondrej Novák, Regina Feil, Analía Delina Dumón, María Fernanda Mattio, Danuše Tarkowská, Gabriela Llauger, Miroslav Strnad, John Edward Lunn, Stephen Pearce, Carlos María Figueroa, Mariana del Vas   +12 more
doaj   +1 more source

Bioactive Steroids from the Red Sea Soft Coral Sinularia polydactyla

Marine Drugs, 2020
Six new (1, 2, 6, 8, 13, and 20) and twenty previously isolated (3–5, 7, 9–12, 14–19, and 21–26) steroids featuring thirteen different carbocycle motifs were isolated from the organic extract of the soft coral Sinularia polydactyla collected from the ...
Mohamed A. Tammam, Lucie Rárová, Marie Kvasnicová, Gabriel Gonzalez, Ahmed M. Emam, Aldoushy Mahdy, Miroslav Strnad, Efstathia Ioannou, Vassilios Roussis   +8 more
doaj   +1 more source

Credit risk in European banks: The bright side of the internal ratings based approach [PDF]

, 2018
This paper investigates the accuracy of internal rating based (IRB) models in measuring credit risk. We contribute to the growing debate on the current prudential regulatory framework by investigating the use of validated IRB models in promoting ...
Arellano, Arroyo, Barakova, Beck, Behn, Behn, Beltratti, Berg, Berger, Bikker, Bofondi, Bruno, Chaibi, Chaibi, Colliard, Danielsson, Danielsson, De Haas, Dimitrios, Doriana Cucinelli, Erdinc, Farhan, Ferri, Foos, Ghosh, Glen, Han, Heckman, Hess, Jimenez, Keeton, Keeton, Kyriazidou, Kyriazidou, Laeven, Laura Nieri, Ledo, Louzis, Lucchetti, Macit, Makri, Malvina Marchese, Marcucci, Maria Luisa Di Battista, Mariathasan, Mascia, Perèz Montes, Plosser, Podpiera, Resti, Salas, Semykina, Wooldridge, Zhang   +53 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The Cytokinin Complex Associated With Rhodococcus fascians: Which Compounds Are Critical for Virulence?

Frontiers in Plant Science, 2019
Virulent strains of Rhodococcus fascians cause a range of disease symptoms, many of which can be mimicked by application of cytokinin. Both virulent and avirulent strains produce a complex of cytokinins, most of which can be derived from tRNA degradation.
Paula E. Jameson, Pragathi Dhandapani, Jiancheng Song, Marek Zatloukal, Miroslav Strnad, Mitja N. P. Remus-Emsermann, Rudolf O. Schlechter, Ondrej Novák   +7 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source