Advanced Science, EarlyView.Lactate‐driven endometrial cancer relapse is mediated by enzymatic protein modification. Elevated lactate levels activate AARS1, which catalyzes K280 lactylation of IGF2BP3, therefore stabilizing HMGA2 mRNA and promoting tumor stemness and recurrence.
Peng Jiang +11 more
wiley +1 more source
Polymorphisms in <i>CALCRL</i> and <i>MPC1</i> Genes and Their Associations with Growth Traits in Tianzhu White Yaks. [PDF]
Animals (Basel)Gu T +12 more
europepmc +1 more source
Multi‐Tissue Crosstalk Regulating Meniscus Healing Under Inflammation and Physiological Loading
Advanced Science, EarlyView.Using a novel Meniscus‐on‐a‐chip (MoC) model integrated with a meniscus‐specific bioreactor, this study investigated the roles of multi‐tissue crosstalk that regulates injury, healing, and degeneration of the meniscus injury under inflammation and pathophysiological loading.
Hun Jin Jeong +5 more
wiley +1 more source
Investigation of changes in the profile of fatty acids and growth traits in response to waterlogging/flooding stress. [PDF]
PLoS OneGul MZ +8 more
europepmc +1 more source
Advanced Science, EarlyView.By integrating 516 whole‐genome resequencing datasets and 236 transcriptomes of allotetraploid common carp, this study establishes the first population‐scale atlas of transposable element (TE) variation in teleost species. TE bursts, relaxed purifying selection, and lineage‐specific loss of ancient insertions shape genome evolution and phenotypic ...
Shuimu Hu +11 more
wiley +1 more source
Genomic Dissection of Growth Traits and Spatial Independence from Breed-Defining Loci in Jining Grey Goats. [PDF]
Animals (Basel)Chen Y +5 more
europepmc +1 more source
Advanced Science, EarlyView.The transcription factor MoSR governs DMI fungicide sensitivity in Magnaporthe oryzae through dual regulation of ergosterol biosynthesis and the detoxification enzyme MoDde1. Targeting MoDde1 via a small‐molecule inhibitor or host‐induced gene silencing enhances DMI efficacy against rice blast, offering a sustainable disease management strategy ...
Fan‐Zhu Meng +10 more
wiley +1 more source
Genetic Architecture of Growth Traits in Turbot (<i>Scophthalmus maximus</i>) Revealed by Genome-Wide Association Studies. [PDF]
Int J Mol SciChen A, Liang S, Jiang L.
europepmc +1 more source
Dual Repression by IPA1 Fine‐Tunes OsbZIP79‐Mediated Salt Tolerance in Rice
Advanced Science, EarlyView.Dual repression by IPA1 fine‐tunes OsbZIP79‐mediated salt tolerance in rice: direct transcriptional inhibition under normal conditions and salt‐induced degradation under stress. This dual mechanism activates OsbZIP79 to regulate Na+/K+ homeostasis and redox balance via downstream genes, enabling optimal salt stress response.
Hui Wang +12 more
wiley +1 more source
Moderate shading improves photosynthetic growth traits and phenanthrene production in Oreorchis patens. [PDF]
Sci RepZhang Z, Zhao J, Hua Y, Zheng P, Lei H.
europepmc +1 more source