Results 191 to 200 of about 153,861 (265)

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

Microenvironment-Activated Fe-MOF Nanoplatform Enables Controlled Doxorubicin Release and Ferroptosis-Associated Oxidative Damage in MCF-7 Breast Cancer Cells. [PDF]

Int J Nanomedicine
Yuan M, Wu Y, Zheng J, Wang C, Wang J, Zheng Y, Wang Y, Wang B.   +7 more
europepmc   +1 more source

IRF‐1 modulates hepatic ferroptosis and aggravates liver ischemia/reperfusion injury via DYRK1α

Animal Models and Experimental Medicine, EarlyView.
IRF‐1 modulates hepatic ferroptosis and aggravates liver ischemia/reperfusion injury via DYRK1α. Abstract Background The purpose is to define the contribution of the interferon regulatory factor‐1–dual‐specificity tyrosine phosphorylation‐regulated kinase 1α (IRF‐1–DYRK1α) axis to hepatocellular ferroptosis during liver ischemia/reperfusion injury ...
Jinping Zhang, Jinming Zhang, Siyuan Song, Mingyang Li, Liying Sun, Zhijun Zhu, Dongdong Lin   +6 more
wiley   +1 more source

Amelioration of Acrolein-Induced Cytotoxicity, Oxidative Stress, DNA Damage, Apoptosis and Mitochondrial Dysfunction in Human Pancreas Cells by Pycnogenol. [PDF]

J Biochem Mol Toxicol
Atlı Şekeroğlu Z, Şekeroğlu V, Kamanlı Ş, Kontaş Yedier S, Aydın B, Börçek Kasurka C.   +5 more
europepmc   +1 more source

The potency of native postbiotics and paraprobiotics in modulating inflammation by affecting the gut–kidney axis

Animal Models and Experimental Medicine, EarlyView.
Native postbiotics and paraprobiotics derived from Lactobacillus and Bifidobacterium strains were administered to dextran sulfate sodium–treated C57BL/6 mice to evaluate their impact on kidney inflammation via the gut–kidney axis. Histological analysis and quantitative polymerase chain reaction of autophagy‐related genes (atg5, atg7, atg12, atg13 ...
Fatemeh Haririzadeh Jouriani, Mahnaz Torfeh, Fatemeh Ashrafian, Niloofar Rezaie, Mohsen Mohammadi, Shadi Aghamohammad, Mahdi Rohani   +6 more
wiley   +1 more source

GSH-Occ: Gradient-Shielded and Height-Aware BEV Occupancy Network. [PDF]

Sensors (Basel)
Ou B, Li T, Lin Z, Wu B, Chen P, Zhou Z, Liu Y, Wang J, Guo J, He L.   +9 more
europepmc   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Tipping the balance: NRF2's dual role in ferroptotic fate. [PDF]

Oncogenesis
de Souza I, da Silva Teixeira AB, Ferreira Dos Santos A, Friedmann Angeli JP, Ribeiro Reily Rocha C.   +4 more
europepmc   +1 more source

A modified D‐galactose‐induced aging rat model with low‐dose intraperitoneal ozone: Redox, functional, and skin outcomes

Animal Models and Experimental Medicine, EarlyView.
Male Wistar rats were subjected to d‐galactose‐induced aging, with or without intermittent low‐dose intraperitoneal ozone administration, and evaluated over 8 weeks for redox status and physical performance, including physical health score, morbidity proportion, body weight, muscle strength, hair regrowth, and skin outcome.
Isabella Kurnia Liem, Raisa Nauli, Firda Asma’ul Husna, Sasanthy Kusumaningtyas, Deswaty Furqonita, Ferbian Milas Siswanto, Soegianto Ali   +6 more
wiley   +1 more source

A BBB-permeable β₃-AR probe enables redox imaging, natural inhibitors discovery, and therapeutic monitoring in glioblastoma. [PDF]

Sci Adv
Cheng W, Chen Z, Liu Y, Luo X, Li Z, Yang H, Zhong Y, Cai X, Sun Z, Zhou L, Zhang B, Zhu HL, Li M, Qian Y.   +13 more
europepmc   +1 more source