Results 151 to 160 of about 70,328 (289)

Co‐Opting MBNL‐Dependent Alternative Splicing Cassette Exons to Control Gene Therapy in Myotonic Dystrophy

Annals of Neurology, EarlyView.
Objective Myotonic dystrophy type 1 (DM1) is a highly variable, multisystemic genetic disorder caused by a CTG repeat expansion in the 3′ untranslated region of DMPK. Toxicity is exerted by repeat‐containing DMPK transcripts that sequester muscleblind‐like (MBNL) proteins and lead to deleterious yet predictable changes in alternative splicing.
Samuel T. Carrell, Ellie M. Carrell, Ryan Giovenco, Beverly L. Davidson   +3 more
wiley   +1 more source

Phosphoinositide 3-kinase inhibitors are effective therapeutic drugs for the treatment of hepatocellular carcinoma? [PDF]

Clinical and Molecular Hepatology, 2020
Jeong Su Park, Soo Han Bae
doaj   +1 more source

Role of p38 MAPK inhibitor in conditioned fear [PDF]

, 2015
p38 mitogen activated protein kinase (p38) is a kinase that has been implicated in cellular plasticity, stress, and psychiatric disorders and recently in the process of DNA repair.
Bauman, Brittany Nicole, Falls, William, Dr.   +1 more
core   +1 more source

Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation [PDF]

, 2016
Plasticity in epithelial tissues relates to processes of embryonic development, tissue fibrosis and cancer progression. Pharmacological modulation of epithelial transitions during disease progression may thus be clinically useful.
Bellomo, C, Bickle, M, Carthy, JM, Gahman, TC, Heldin, A, Heldin, CH, Kardassis, D, Morén, A, Moustakas, A, Shiau, AK, Stöter, M, Vanlandewijck, M, Zerial, M   +12 more
core   +1 more source

Compensation Response to Hepatic Gluconeogenesis via β‐Hydroxybutyrylation of FBP1 and PCK1 in Dairy Cows

Animal Research and One Health, EarlyView.
(1) Kbhb modification of FBP1 and PCK1 is involved in regulation of the gluconeogenesis pathway. (2) Kbhb of FBP1 and PCK1 is catalyzed by p300 and removed by HDACs. (3) BHB induced an increase in the enzymatic activity of FBP1 and PCK1 through Kbhb modification at the K43 site of FBP1 and the K191 site of PCK1.
DingPing Feng, GuoYan Wang, YuanYuan Zhu, YiNing Zheng, JunHu Yao, Lei Chen, Lu Deng   +6 more
wiley   +1 more source

Mathematical and Statistical Techniques for Systems Medicine: The Wnt Signaling Pathway as a Case Study

, 2015
The last decade has seen an explosion in models that describe phenomena in systems medicine. Such models are especially useful for studying signaling pathways, such as the Wnt pathway.
A Gelman, A Saltelli, AC Babtie, AG Fletcher, AL MacLean, AL MacLean, AR Hernández, B Alberts, B Carlin, B Lloyd-Lewis, BR Henderson, CW Gardiner, CW Tan, CW Tan, CY Logan, D Brewer, D Cox, D Kim, E Feliu, E Lee, ER Barry, F Cong, G Craciun, G Craciun, G Craciun, GR Mirams, H Clevers, H Kitano, HA Harrington, I Ramis-Conde, IMM Leeuwen van, J Franca-Koh, J Heuberger, J Jost, J Liepe, J Liepe, J Neumann von, J Stark, J Stelling, J. Kevorkian, K Itoh, KH Cho, L Goentoro, L Vermeulen, M Basan, M Beguerisse-Díaz, M Feinberg, M Feinberg, M Kuhl, M Secrier, M Sunnåker, N Blüthgen, N Gershenfeld, N Gilbert, N Wiechens, O Ratmann, P Buske, P Glendinning, P Kirk, P Polakis, PJ Murray, PJ Murray, R Habas, R Krüger, RN Gutenkunst, S Wolfram, T Reya, T Toni, VSW Li, X Varelas, Y Kogan, Y Schmitz, Y Schmitz, Y Zhou   +73 more
core   +1 more source

A dysfunctional TRPV4–GSK3β pathway prevents osteoarthritic chondrocytes from sensing changes in extracellular matrix viscoelasticity

Nature Biomedical Engineering, 2021
P. Agarwal, Hong-pyo Lee, P. Smeriglio, F. Grandi, S. Goodman, Ovijit Chaudhuri, N. Bhutani   +6 more
semanticscholar   +1 more source

Exploring the Anti‐Diabetic Potential of Anthocyanins: From Biochemical Pathways to Human Trials

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT Diabetes mellitus (DM) is a global health challenge with increasing prevalence rates, particularly in low‐ and middle‐income countries. Anthocyanins (ACs) are potential bioactive compounds found in various fruits and vegetables, attracting the attention of researchers due to their possible role in managing diabetes and its complications ...
Lakshay Panchal, Sangeeta Yadav, Akash Kumar, Tanbeer Kaur, Yashna Bawa, Sarvesh Rustagi, Rahul Mehra   +6 more
wiley   +1 more source

Harnessing Piezoelectric Biomaterials for Pathogenic Eradication and Tissue Regeneration

Exploration, EarlyView.
This review highlights recent advances in piezoelectric biomaterials for antibacterial therapy and tissue regeneration, discussing material classifications, catalytic mechanisms, property enhancements, biomedical applications, and future challenges in clinical translation.
Wenxuan Mao, Xiaoye Li, Ao He, Meng Ding, Yu Zhang, Zhuo Dai, Qiang Li, Weijun Xiu, Yanling Hu, Yongbin Mou, Dongliang Yang, Heng Dong   +11 more
wiley   +1 more source

Corilagin alleviates acetaminophen-induced hepatotoxicity via enhancing the AMPK/GSK3β-Nrf2 signaling pathway

Cell Communication and Signaling, 2019
BackgroundAcetaminophen (APAP) overdose-induced acute liver failure (ALF) is mainly resulted from uncontrolled oxidative stress. Nuclear factor-erythroid 2-related factor 2 (Nrf2), a key antioxidant transcription factor, is essential for alleviating APAP-
Hongming Lv, L. Hong, Ye Tian, Changjiu Yin, Chao Zhu, Haihua Feng   +5 more
semanticscholar   +1 more source