Targetable Vulnerabilities in MYC‐Driven B Cell Lymphomas Resistant to BCR Extinction
Hematological Oncology, Volume 44, Issue 2, March 2026.ABSTRACT Polatuzumab vedotin, an antibody‐drug conjugate (ADC) targeting the B cell receptor (BCR) signaling subunit CD79B, has recently entered frontline therapy for diffuse large B cell lymphoma (DLBCL) and high‐grade B cell lymphoma (HGBCL), achieving encouraging clinical results. However, MYC‐driven B cell lymphomas, particularly HGBCL with MYC and
Silvia Brambillasca +15 more
wiley +1 more source
O-GlcNAcylation expression predicts a favorable prognosis and mitigates malignant phenotypes via MYCN suppression in neuroblastoma. [PDF]
Mol Cell PediatrLin NY +9 more
europepmc +1 more source
Neuropsychopharmacology Reports, Volume 46, Issue 1, March 2026.We analyzed the behavior of GPR143 gene‐deficient mice. GPR143‐KO mice displayed a mixed psychiatric phenotype. GPR143 may play a role in mesolimbic and mesocortical functions underlying sensory gating, reward, social hierarchy, cognition, and emotional regulation. ABSTRACT GPR143, originally identified as the gene product of ocular albinism 1 (OA1), a
Yoshio Goshima +9 more
wiley +1 more source
The Impact of Decreased GSK3β and S6K1 Expression in TNBC Patients. [PDF]
Life (Basel)Tomić T +8 more
europepmc +1 more source
MAP1B Variants Disrupt Neuronal Migration: Insights From Three Novel Families
Clinical Genetics, Volume 109, Issue 3, Page 558-563, March 2026.Pathogenic variants in MAP1B have recently emerged as a cause of neurodevelopmental disorders characterized by intellectual disability, epilepsy, and cortical malformations, including periventricular nodular heterotopia (PVNH) and polymicrogyria (PMG).
Jessica Archer +4 more
wiley +1 more source
NDRG4 overexpression is associated with reduced apoptosis after intracerebral hemorrhage via the PI3K/Akt/GSK3β signaling pathway. [PDF]
Sci RepWang X +6 more
europepmc +1 more source
IGFBP4 is a Metric for Primary Biliary Cholangitis and Attenuates Biliary Epithelial Cell Injury
Liver International, Volume 46, Issue 3, March 2026.ABSTRACT Background and Aims Immune‐mediated bile duct injury is the primary histological feature of autoimmune cholestatic liver diseases. Macrophages, the most abundant immune cell population in the liver, have been postulated to play a critical role in biliary repair. However, it is unclear whether activated macrophages interact with injured biliary
Xing Zhou +12 more
wiley +1 more source
Alantolactone Inhibits Double Expression Lymphoma via Dual-Targeted Glycogen Synthase Kinase 3 Beta and B-Cell Lymphoma2. [PDF]
Blood Lymphat CancerChen J +10 more
europepmc +1 more source
Pan‐cancer analysis reveals molecular signatures for predicting matrix stiffness in solid tumors
International Journal of Cancer, Volume 158, Issue 4, Page 1093-1105, 15 February 2026.What's new? Tumor matrix stiffness plays a critical role in cancer progression, metastasis, and therapy resistance. Here, the authors leveraged tumor RNA‐seq data to identify molecular signatures of mechanical properties across various cancer types and build a computational model for predicting tumor matrix stiffness.
Gongyu Tang +6 more
wiley +1 more source
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, Volume 16, Issue 2, Page 252-267, February 2026.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source