Results 221 to 230 of about 70,328 (289)

GSK3β guides chromosomal repair pathway selection to support BRCA1-independent PARP inhibitor sensitivity. [PDF]

J Clin Invest
Leung JW, Gius D.
europepmc   +1 more source

Metformin‐Mediated Glycaemic Regulation as a Potential Strategy for Breast Cancer Prevention

Cancer Medicine, Volume 15, Issue 2, February 2026.
Metformin (MET), a common antihyperglycemic drug, shows promising anti‐cancer effects in breast cancer (BC). It activates adenosine monophosphate‐activated protein kinase (AMPK), regulating cellular energy and inducing cell cycle arrest, anti‐proliferation, and microenvironment alterations.
Ambulugala Gamage Rajika Greshamali Jinadasa, N. D. Amal Wageesha, Sameera R. Samarakoon, Sagarika Ekanayake, H. M. Kasuni Akalanka   +4 more
wiley   +1 more source

The dual role of glycogen synthase kinase-3 beta (GSK3β) in neurodegenerative pathologies: interplay between autophagy and disease progression. [PDF]

Front Pharmacol
Alhassan HH, Janiyani K, Surti M, Adnan M, Patel M.   +4 more
europepmc   +1 more source

TREM2 Facilitates Myelin Debris Clearance but Exacerbates Chronic Inflammation and Fibrosis After Spinal Cord Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
After spinal cord injury (SCI), TREM2 promotes myelin debris clearance and disease‐associated microglia (DAM) activation that support early repair. However, sustained TREM2‐dependent DAM activation may aggravate chronic inflammation and fibrosis, whereas TREM2 deficiency alleviates these effects, identifying TREM2 as a key regulator of microglial ...
Zhonghan Wu, Shuisheng Yu, Yixue Hu, Xuyang Hu, Linhan Yang, Yan Jiang, Mengdi Zhang, Yiyang Mu, Ziyu Li, Fei Yao, Dasheng Tian, Juehua Jing, Li Cheng   +12 more
wiley   +1 more source

UBE3A stabilization of β-catenin preserves synaptic proteins essential for motor and cognitive functions in Angelman Syndrome. [PDF]

Mol Autism
Yang X, Huang YA, Marshall J.
europepmc   +1 more source

Salvia coccinea and Apigenin: A Natural Treasure of Lamiaceae in Pharmacological Innovation

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Salvia coccinea is rich in bioactive phytochemicals, notably the flavonoid apigenin, offering strong antioxidant, anti‐inflammatory, and antimicrobial effects. By modulating inflammatory and oxidative pathways, it shows potential for managing chronic diseases.
Muhammad Usman Khalid, Muhammad Tauseef Sultan, Muhammad Maaz, Shehnshah Zafar, Anum Shoukat, Nudrat Khursheed, Matteo Bordiga, Amna Junaid   +7 more
wiley   +1 more source

The structural requirements of 3,5-substituted oxindoles that determine selective AMPK or GSK3β inhibition. [PDF]

RSC Med Chem
Strang JE, Astridge DD, Chandler C, Nguyen VT, Reigan P.   +4 more
europepmc   +1 more source

Wild Prunus cerasifera Ehrh. Polyphenols Alleviate Hyperglycemia in Type 2 Diabetes Mellitus Mice via Modulating Gut Microbiota‐SCFAs‐PI3K/Akt/TBC1D4 Pathway

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
WPPE treatment significantly alleviated type 2 diabetes by improving SCFAs and gut microbiota composition and promoted glycogen synthesis by regulating the PI3K/AKT/TBC1D4 pathway. WPPE also improved liver function and reduced oxidative stress and inflammation. ABSTRACT Our previous work demonstrated that wild Prunus cerasifera Ehrh.
Xinpeng Cheng, Xing Xie, Shibo Luo, Quanyuan Xie, Haiyan Xiang, Chunyan Peng, Qiao Ding, Hongbing Fan, Wei Liu, Lu Zhang   +9 more
wiley   +1 more source

Andrographolide inhibits the upregulation of SLC19A3 to block the adipogenic differentiation of adipose-derived stem cells. [PDF]

iScience
Yang Y, Wang X, Zhou G, Hou X, He Y, Feng Y, Jiang Y, Gu Y, Ye J.   +8 more
europepmc   +1 more source

Kaempferol Attenuates Oxidative Stress‐Induced Injury in Gastric Mucosal Cells by Activating Nrf2/GPX4 Axis to Inhibit Ferroptosis

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Objective This study explores how Kaempferol (KAE) protects against oxidative stress‐induced damage by suppressing ferroptosis via the Nrf2/GPX4 axis in gastric mucosal cells. Methods Human gastric epithelial cells (GES‐1) were treated with H₂O₂ to induce oxidative damage, following pretreatment with varying doses of KAE.
Chao Luo, Jing Yan, Yun Shen, Zhiguang Sun, Xiong Xiao   +4 more
wiley   +1 more source