Results 241 to 250 of about 70,328 (289)

Homoharringtonine Promotes FTO Degradation to Suppress LILRB4‐Mediated Immune Evasion in Acute Monocytic Leukaemia

Cell Proliferation, Volume 59, Issue 2, February 2026.
Homoharringtonine (HHT) suppresses immune evasion in acute monocytic leukaemia (AML‐M5) by attenuating the FTO/m6A/LILRB4 axis, thereby enhancing CD8+ T cell cytotoxicity. ABSTRACT Acute monocytic leukaemia, a subtype of acute myeloid leukaemia (AML), is a highly aggressive malignancy characterised by a poor prognosis, primarily due to the ability of ...
Fangfang Huang, Xiang Luo, Mengyu Zhang, Le Jin, Wenxin Sun, Peihan Chen, Xiuli Hong, Chenyu Xu, Meizhi Jiang, Die Hu, Bin Zhang, Shengwei Hu, Chuanjiang Yang, Rui Gao, Jinzhang Zeng, Quanyi Lu, Qiang Luo, Jun Wu, Siming Chen   +18 more
wiley   +1 more source

Selenium Attenuates Dexamethasone-Induced Osteoblast Dysfunction and Prevents Femoral Head Osteonecrosis via PI3K/AKT/GSK3β Pathway Activation. [PDF]

Orthop Surg
Xuecheng S, Changjun C, Xiaojie M, Shufeng L, Lei Z, Ma X.   +5 more
europepmc   +1 more source

Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3β-Nrf2 signal axis

Redox Biology, 2017
Hongming Lv, Qinmei Liu, Zhongmei Wen, Haihua Feng, Xuming Deng, X. Ci   +5 more
semanticscholar   +1 more source

Dysregulation of Rho‐Associated Coiled‐Coil Protein Kinase1 Depletes Neural Stem Cell Pool and Impairs Hippocampal Neurogenesis After Traumatic Brain Injury

Cell Proliferation, Volume 59, Issue 2, February 2026.
Following TBI, hippocampal neurogenesis in mice is impaired and affects cognitive function. This impairment is associated with the upregulation of p‐AKT/AKT mediated by ROCK1. ABSTRACT Traumatic brain injury (TBI) represents a global health burden, often resulting in persistent neurological deficits due to impaired hippocampal neurogenesis ...
Chaoqun Yao, Long Jin, Jun Zhong, Qianying Huang, Zhongwei Bao, Shaolong Zhou, Chaohua Wang, Huanhuan Li, Xiaowei Yuan, Zhen Wang, Ning Du, Jingxuan Yu, Huanran Chen, Xuyang Zhang, Hongfei Ge, Jianheng Wu   +15 more
wiley   +1 more source

ROCK inhibition promotes axon and myelin regeneration via PI3K/Akt/GSK3β in a mouse sciatic nerve injury model. [PDF]

Int J Mol Med
Dou S, Li Z, Zheng B, Ren Z, Wang H, Zuo Q, Fang F, Zhuang Y.   +7 more
europepmc   +1 more source

Can Environmental Enrichment Mitigate Cell Apoptosis in the Central Nervous System Under Adverse Health Conditions? A Systematic Review

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT To summarize the available evidence in the literature regarding the effects of exposure to an enriched environment (EE) on the modulation of apoptotic markers in central tissue of rodents under unfavorable conditions. Searches were conducted in three databases: PubMed/Medline (70 articles), Scopus (65 articles), and EMBASE (128 articles), all ...
Matheus Santos de Sousa Fernandes, Diorginis José Soares Ferreira, Fatma Hilal Yagin, Georgian Badicu, Gabriela Carvalho Jurema Santos, Maria Carolina Santos Guedes, Fabrício Oliveira Souto, Luca Paolo Ardigò   +7 more
wiley   +1 more source

STK38-mediated feedback loop regulation of the hedgehog pathway governing tumor heterogeneity in renal papillary carcinoma. [PDF]

Cell Death Dis
Du Y, Sui X, Zheng Z, Zhang Z, Liu B, Bai Y, Zhao Y, Wu Q, Wu H, Zhong M, Li L, Sun H, Shao C.   +12 more
europepmc   +1 more source

MSC‐Derived Secretome and Exosomes in Dermatology: Mechanisms, Therapeutic Opportunities, and Scientific Challenges—A Narrative Review

International Journal of Dermatology, Volume 65, Issue 2, Page 257-272, February 2026.
ABSTRACT Mesenchymal stromal cells (MSCs) exert their effects primarily through paracrine signaling via soluble factors and extracellular vesicles (EVs), especially exosomes. These acellular components offer regenerative and immunomodulatory benefits with fewer safety and logistical constraints than cell‐based therapies.
Marcela da Costa Pereira Cestari, Reinaldo Falavigna Tovo, Daniela Franco Bueno   +2 more
wiley   +1 more source

Anticancer Activity of 2,3'-Dihydroxy-5'-Methoxystilbene Against NSCLC Cell Lines Through AKT-Dependent Mechanisms: A Comprehensive In Vitro and Computational Analysis. [PDF]

Int J Mol Sci
Pouyfung P, Lertnitikul N, Ogino N, Chookaew A, Pongrakhananon V, Chonsut P, Sueangoen N, Chaisit S.   +7 more
europepmc   +1 more source

Novel miR-290 regulates melanogenesis in Liancheng white ducks via the PI3K/AKT signaling pathway. [PDF]

Poult Sci
Xin Q, Shi W, Liu X, Huang L, Li L, Zhu Z, Zhang L, Miao Z, Cai Q, Zhao B, Huang Q, Zheng N.   +11 more
europepmc   +1 more source