Results 251 to 260 of about 70,328 (289)

Immunomodulatory Mechanism of Baiyaojian Decoction on Periodontitis: Network Pharmacology, Single‐Cell RNA Sequencing and Molecular Docking

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Periodontitis is one of the most common oral inflammatory diseases. Baiyaojian decoction, known for its prominent immunomodulatory and anti‐inflammatory properties, shows significant potential in treating periodontitis, though its molecular mechanisms remain unknown. The active ingredients and therapeutic targets were determined by integrating
Bing‐jun Chen, Ming‐ming Li, Zhao‐yu Zheng, Wen‐qin Jin, Zhao Jin, Yu‐ling Zuo   +5 more
wiley   +1 more source

β-Catenin and AMPK/AKT/FOXO Signaling Mediate Doxorubicin-Induced Senescence and Lipid Accumulation in C2C12 Myoblasts. [PDF]

Biomol Ther (Seoul)
Yun C, Kim SH, Kwon D, Woo R, Chung KW, Lee J, Lee YH, Jung YS.   +7 more
europepmc   +1 more source

Lithium chloride corrects weakness and myopathology in a preclinical model of LGMD1D [PDF]

, 2019
Bengoechea, Rocio, Chou, Tsui-Fen, Findlay, Andrew R., Pittman, Sara K., True, Heather L., Weihl, Conrad C.   +5 more
core   +1 more source

T Cell Exhaustion in Hepatocellular Carcinoma: A Substantial Barrier in Immunotherapy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Hepatocellular carcinoma (HCC), accounting for over 90% of primary liver cancers, remains a major global challenge for healthcare professionals. While immunotherapy has transformed the landscape of cancer treatment, its success is often limited by immune resistance, particularly through T cell exhaustion which remains a major barrier to ...
Kosar Nouri, Negar Asadollahei, Yasamin Haghir‐Sharif‐Zamini, Homeyra Seydi, Mahsa Salehi, Mehrnaz Mesdaghi, Mustapha Najimi, Massoud Vosough   +7 more
wiley   +1 more source

LRRC1 Promotes Angiogenesis Through Regulating AKT/GSK3β/β-Catenin/VEGFA Signaling Pathway in Hepatocellular Carcinoma. [PDF]

Cells
Liu H, Liu Z, Xie P, Liu Z, Zhang Y, Cao L, Shang N, Chen M, Feng H, Guan X, Dai G.   +10 more
europepmc   +1 more source

Bidirectional Communication Between Astrocytes and Neurons via Extracellular Vesicles: A Multi‐Omics Approach

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
Schematic diagram illustrating the communication between mouse hippocampal astrocytes and neurons through extracellular vesicles (EVs). The illustration highlights unique proteins secreted by each cell type within EVs, with vesicle size proportional to the concentration of secreted proteins.
Daria Hajka, Paulina Żebrowska‐Różańska, Katarzyna Romańczuk, Jacek R. Wiśniewski, Łukasz Łaczmański, Norbert Łodej, Krzysztof J. Pawlik, Dariusz Rakus, Agnieszka Gizak   +8 more
wiley   +1 more source

Diagnostic ultrasound-microbubble therapy promotes wound healing through miR-26b-5p-mediated GSK3β suppression. [PDF]

Sci Rep
Huang N, Sun N, Yang H, Wang R, Li L, Tao J, Feng Q, Chen Z.   +7 more
europepmc   +1 more source

USP10 in Neurological Disorders: Mechanistic Insights and Emerging Therapeutic Strategies

Annals of the New York Academy of Sciences, Volume 1556, Issue 1, February 2026.
USP10 is a deubiquitinating enzyme that affects neurological diseases through multiple mechanisms, including the accumulation of toxic proteins, autophagy, and immune responses. In this review, we discuss the structure and characteristics of USP10 and summarize the role of USP10 in neurological disorders.
Celemuge, Hongying Sun, Jia Zhang, Yang Yang, Jian Mao, Cheliger   +5 more
wiley   +1 more source

Label-free optical observation of disordered-to-ordered transitions in single intrinsically disordered proteins

Zargarbashi S, Dominguez C, Peters M, Yousefi A, Munday S, Wang Y, Chatterjee S, Hudson A, Gordon R, Mellor CJ, Xu L, Rahmani M, Ying C.   +12 more
europepmc   +1 more source

STAT3 Signaling Mediates Agomelatine Restoration of Prefrontal Cortex Synaptic Plasticity in Chronic Social Defeat Stress Mice. [PDF]

Mol Neurobiol
Lee CW, Wu HF, Yen HJ, Liao LD, Mao WC, Chang HS, Chen YF, Lin CH, Li CT, Lin HC.   +9 more
europepmc   +1 more source