Results 261 to 270 of about 70,328 (289)

Unlocking the Therapeutic Potential of Integrin‐Linked Kinase Inhibitors in Bioengineered 3D Breast Tumor Stroma Models

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
3D cancer models provide a more reliable representation of drug responses compared to 2D cell culture owing to their 3D architecture and facilitation of cell‐extracellular matrix interactions. In this study, we engineered dense compartmentalized 3D tumoroids composed of breast tumor mass and a surrounding stromal compartment replicating either breast ...
Salma T. Rafik, Anuja Upadhyay, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Apoptosis, Cell Growth, and Glycogen Synthase Kinase 3β Phosphorylation in Caffeic Acid-Treated Human Malignant Melanoma Cells. [PDF]

Biomedicines
Lee YJ, Kim KD, Choi MH, Park SQ, Choi YS, Bae Y, Nam HS, Lee SH, Cho MK.   +8 more
europepmc   +1 more source

Persimmon carotenoid extract rich in β‐cryptoxanthin improves glucose homeostasis and reduces liver damage in high‐fat‐diet‐induced type 2 diabetic and metabolic dysfunction‐associated steatotic liver disease mice

Journal of the Science of Food and Agriculture, Volume 106, Issue 2, Page 1299-1313, 30 January 2026.
Abstract Background Persimmon (Diospyros kaki Thunb.) byproducts are a remarkable source of bioactive compounds, particularly carotenoids. Several studies suggest that carotenoids have beneficial effects in prevention of a large number of diseases. This study aims to highlight the effects of a persimmon carotenoid extract (PSCE) rich in β‐cryptoxanthin
Bryan Moreno‐Chamba, Nuria Martí, Antonio Cárdenas, María Soledad Fernández‐Pachón, Blanca Escudero‐López, Franz Martín, Julio Salazar‐Bermeo, Manuel Valero, Domingo Saura, María Concepción Martínez‐Madrid, Genoveva Berná   +10 more
wiley   +1 more source

Computational Modeling of PI3K/AKT Pathway in Bipolar Disorder and Type 2 Diabetes: Implications for Lithium Treatment and Curcumin as a Potential Alternative. [PDF]

Int J Mol Sci
Li J, Wang W, Wang Y, Hao Y, Fu L, Liu X.   +5 more
europepmc   +1 more source

Inhibiting Glycogen Synthase Kinase 3 Suppresses TDP-43-Mediated Neurotoxicity in a Caspase-Dependent Manner. [PDF]

Mol Neurobiol
White MA, Crowley L, Massenzio F, Li X, Niblock M, Milani S, Coleman MP, Barmada SJ, Sreedharan J.   +8 more
europepmc   +1 more source

GSK3β Promotes Ferroptosis as a Mediator of MASH in Mice. [PDF]

Cell Mol Gastroenterol Hepatol
Neuschwander-Tetri BA, Chakraborty A.
europepmc   +1 more source

Stimulation at the frontal cortex influences the exercise activity and skeletal muscle status in senescence-accelerating mice. [PDF]

NPJ Aging
Nagaoka N, Eguchi A, Ma N, Kawanokuchi J, Yamamoto T, Tempaku M, Izuoka K, Okabe J, Iwasa M, Nakagawa H, Kobayashi Y.   +10 more
europepmc   +1 more source

Targeting the Primordial Chaperone to Overcome Acquired Drug Resistance in Cancer: TG2-Mediated Autophagy. [PDF]

Biomol Ther (Seoul)
Kim SY.
europepmc   +1 more source

Correction: Danggui Shaoyao San attenuates depressive-like behaviors in mice via TLR4/NF-κB p65/JAK-STAT3/AKT-GSK3β signaling pathways: modulation of hippocampal neurogenesis and neuroinflammation. [PDF]

Front Nutr
Tang CF, Li F, Ma LH, Wang QN, Xie PF, Xiang L, Zhu YJ, Wang YY, Zhang YZ, Shi JJ, Li SJ, Li JM.   +11 more
europepmc   +1 more source

Retraction: LRP6 knockdown ameliorates insulin resistance via modulation of autophagy by regulating GSK3β signaling in human L02 hepatocytes. [PDF]

Front Endocrinol (Lausanne)
Frontiers Editorial Office.
europepmc   +1 more source