Results 281 to 289 of about 70,328 (289)

Aggregation Characteristics of Tau Phosphorylated by Various Kinases as Observed by Quantum Dot Fluorescence Imaging. [PDF]

Int J Mol Sci
Ishibashi E, Araya K, Nakamura K, Shimamori K, Uwai K, Kuragano M, Tokuraku K.   +6 more
europepmc   +1 more source

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Natural compounds regulate the PI3K/Akt/GSK3β pathway in myocardial ischemia-reperfusion injury

Cell Cycle, 2023
The PI3K/Akt/GSK3β pathway is crucial in regulating cardiomyocyte growth and survival. It has been shown that activation of this pathway alleviates the negative impact of ischemia-reperfusion.
Amir Hossein Ajzashokouhi, R. Rezaee, Navid Omidkhoda, G. Karimi   +3 more
semanticscholar   +1 more source

Rutin prevents inflammation-associated colon damage via inhibiting the p38/MAPKAPK2 and PI3K/Akt/GSK3β/NF-κB signalling axes and enhancing splenic Tregs in DSS-induced murine chronic colitis.

Food & Function, 2021
A large body of emerging evidence has revealed the role of p38/MK2 and PI3K/Akt/GSK3β cascades in the orchestrating process of colitis. Rutin, a bioflavonoid present in many fruits and vegetables, has been recognized to offer therapeutic attributes in ...
Ana R. Sharma, N. Tirpude, M. Kumari, Y. Padwad   +3 more
semanticscholar   +1 more source

Fisetin mitigates hepatic ischemia-reperfusion injury by regulating GSK3β/AMPK/NLRP3 inflammasome pathway.

Hepatobiliary & Pancreatic Diseases International, 2021
BACKGROUND Hepatic ischemia-reperfusion (I/R) injury (IRI) represents a crucial challenge in liver transplantation. Fisetin has anti-inflammatory, anti-aging and anti-oxidative properties. This study aimed to examine whether fisetin mitigates hepatic IRI
Junliang Pu, Zuo-Tian Huang, Yunhai Luo, Tong Mou, Ting-ting Li, Zhongtang Li, Xufu Wei, Zhongjun Wu   +7 more
semanticscholar   +1 more source

GSK3β phosphorylation catalyzes the aggregation of tau into Alzheimer's disease-like filaments

Proceedings of the National Academy of Sciences of the United States of America
Significance Alzheimer’s disease (AD) is characterized by the accumulation of neurofibrillary tangles within neurons, primarily composed of insoluble aggregates of tau protein.
Pijush Chakraborty, Alain Ibáñez de Opakua, Jeffrey A Purslow, Simon A Fromm, Debdeep Chatterjee, Milan Zachrdla, Shannon Zhuang, Sambhavi Puri, Benjamin Wolozin, Markus Zweckstetter   +9 more
semanticscholar   +1 more source

siRNA Mediated GSK3β Knockdown Targets Insulin Signaling Pathway and Rescues Alzheimer's Disease Pathology: Evidence from In Vitro and In Vivo Studies.

ACS Applied Materials and Interfaces, 2021
Sporadic Alzheimer's disease (sAD) is a progressive neurodegenerative disorder with dysfunctional insulin signaling and energy metabolism. Emerging evidence suggests impairments in brain insulin responsiveness, glucose utilization, and energy metabolism ...
Smriti Gupta, Vishal Singh, S. Ganesh, N. Singhal, R. Sandhir   +4 more
semanticscholar   +1 more source

Dulaglutide ameliorates STZ induced AD-like impairment of learning and memory ability by modulating hyperphosphorylation of tau and NFs through GSK3β.

Biochemical and Biophysical Research Communications - BBRC, 2019
Dulaglutide, a novel long-acting glucagon-like peptide 1 (GLP-1) receptor agonist, is an incretin mimetic approved for type 2 diabetes mellitus (T2DM) treatment. Alzheimer's disease (AD) is called type 3 diabetes.
Mei Zhou, Shuyi Chen, Peng Peng, Zhongya Gu, Jing Yu, Gang Zhao, Yan-qiu Deng   +6 more
semanticscholar   +1 more source

Theoretical Studies on the Selectivity Mechanisms of Glycogen Synthase Kinase 3β (GSK3β) with Pyrazine ATP-competitive Inhibitors by 3DQSAR, Molecular Docking, Molecular Dynamics Simulation and Free Energy Calculations

Current Computer-Aided Drug Design, 2020
openaire   +1 more source