Results 21 to 30 of about 13,842,156 (196)

PACAP signaling is not involved in GTN- and levcromakalim-induced hypersensitivity in mouse models of migraine

The Journal of Headache and Pain, 2022
Background Calcitonin gene-related peptide (CGRP) antagonizing drugs represents the most important advance in migraine therapy for decades. However, these new drugs are only effective in 50–60% of patients.
Song Guo, Charlotte Ernstsen, Anders Hay-Schmidt, David Møbjerg Kristensen, Messoud Ashina, Jes Olesen, Sarah Louise Christensen   +6 more
doaj   +6 more sources

Chemotherapy resistance and risk stratification in gestational trophoblastic neoplasia: A systematic review and network meta-analysis. [PDF]

Acta Obstet Gynecol Scand
Higher pretreatment β‐hCG, greater tumor burden, higher FIGO stage/score, and choriocarcinoma were associated with higher chemoresistance risk in gestational trophoblastic neoplasia. In exploratory network analyses, etoposide‐containing regimens showed lower predicted chemoresistance.
Xue YY, Yang XY, Chen FY, Yang HT, Zhang C, Yan JZ, Wu SS, Wang L.   +7 more
europepmc   +2 more sources

Application of the GTN Model in Ductile Fracture Prediction of 7075-T651 Aluminum Alloy

, 2016
In this paper the capability of Gurson-Tvergaard-Needleman (GTN) model in theprediction of ductile damage in 7075-T651 aluminum alloy is investigated.
Moud, Saeid Hadidi, Hosseini, SF
core   +10 more sources

Tear Fluid Calcitonin Gene-Related Peptide Levels Are Elevated in Glycerol Trinitrate-Induced Cluster Headache Attacks: Results From an Exploratory Study. [PDF]

Eur J Neurol
Cluster headache (CH) is a severe primary headache disorder and the neuropeptide calcitonin gene‐related peptide (CGRP) has been shown to be elevated ictally and interictally. We investigated tear fluid CGRP levels during experimental cluster headache attacks and showed elevated CGRP levels during these headache attacks.
Kamm K, Angelhuber M, Le Prince AM, Straube A, Ruscheweyh R.   +4 more
europepmc   +2 more sources

Blood Pressure Reduction Time Windows in Stroke: A Systematic Review and Network Meta-Analysis. [PDF]

Brain Behav
ABSTRACT Background The optimal time windows for blood pressure reduction (BPR) treatment in patients with stroke remain controversial. This systematic review and network meta‐analysis (NMA) evaluates the efficacy of different BPR time windows across stroke subtypes and assesses associated safety outcomes.
Yu X, Shi C, Wang W, Xue D, Jiang Y, Zhao M.   +5 more
europepmc   +2 more sources

Cohesive GTN model for ductile fracture simulation

Engineering Fracture Mechanics, 2021
The present work addresses the micromechanical modeling and the simulation of crack initiation and propagation in ductile materials failing by void nucleation, growth and coalescence. A cohesive–volumetric approach is used and the overall material behavior is characterized both by a hardening bulk constitutive law and a softening surface traction ...
Noé Brice Nkoumbou Kaptchouang, Yann Monerie, Frédéric Perales, Pierre-Guy Vincent   +3 more
openaire   +2 more sources

Annexin A1 exerts analgesic effect in a mouse model of medication overuse headache

iScience, 2023
Summary: Medication overuse headache (MOH) is a serious global condition. The interaction between headache attacks and medication overuse complicates the understanding of its pathophysiology.
Zihua Gong, Chunxiao Yang, Wei Dai, Shuai Miao, Yingyuan Liu, Zhiyang Jiao, Bozhi Li, Wei Xie, Wei Zhao, Xun Han, Shengyuan Yu, Zhao Dong   +11 more
doaj   +1 more source

The Effect of Intensive Blood Pressure Reduction on Perihematomal Edema After Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis. [PDF]

Brain Behav
This systematic review and meta‐analysis suggests that intensive blood pressure reduction is associated with modestly smaller approximately 24‐h perihematomal edema expansion after spontaneous intracerebral hemorrhage, supporting further standardized trials to clarify whether early edema attenuation contributes to clinical benefit.
Li X, Zou C, Jia Y, Pan C, Ye X, Zhu S, Huang S.   +6 more
europepmc   +2 more sources

AZ31 Sheet Forming by Clustering Ball Spinning-Analysis of Damage Evolution Using a Modified GTN Model

Metals, 2022
Clustering ball spinning (CBS) forming is a novel approach to manufacturing a complex curved surface. In order to explore the forming limit of magnesium alloy in the CBS forming process, the modified GTN model was incorporated into the FE simulation to ...
Zhiqing Hu, Lijia Da, Jia Xi, Xinchen Li
doaj   +1 more source

A GTN-like Model for Plastic Porous Materials

Engineering, Technology & Applied Science Research, 2014
An extended version of the well-known Gurson-Tvergaard-Needleman (GTN) isotropic hardening model is presented in this paper. The yield function of the proposed constitutive model possesses the distinctiveness to explicitly depend upon the third stress invariant. The presented constitutive model is used to analyze the necking of a round tensile bar.
Siad, L., Gangloff, S. C.
openaire   +3 more sources