Results 141 to 150 of about 328,040 (284)
Cytoskeleton, EarlyView.ABSTRACT Microtubules are noncovalent polymers assembled from α/β tubulin dimers. Their structure, dynamics and interaction with effectors are regulated through the expression of diverse tubulin isotypes and chemically diverse posttranslational modifications, also known as the “tubulin code.” Understanding the biophysical correlates between tubulin ...
Jiayi Chen +2 more
wiley +1 more source
Visualizing Specific Tubulin Isotypes and Pathogenic Variants in Cellular Microtubule Arrays
Cytoskeleton, EarlyView.ABSTRACT Eukaryotic cells depend on dynamic microtubule arrays to execute a wide range of functions vital for life. These microtubule filaments are formed through the polymerization of α/β‐tubulin proteins, which can be generated from numerous tubulin genes, or isotypes.
Sareen Fiaz +2 more
wiley +1 more source
The role of Rho GTPases in facial morphogenesis
Developmental Dynamics, EarlyView.The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley +1 more source
Dietary and biomarker‐guided strategies as supportive measures in the fragile X syndrome
Food Biomacromolecules, EarlyView.Abstract The fragile X syndrome (FXS) is an inherited neurodevelopmental disorder that primarily affects males, often resulting in an IQ below 55, while about two‐thirds of females also experience intellectual disability. Physical features may include an elongated face, prominent ears, finger joint laxity, and enlarged testes in males.
Jailan E. El Halawani, Reem R. AlOlaby
wiley +1 more source
Induced opening of conformational switch I in GTP-bound Ran GTPase. [PDF]
Protein SciCzigleczki J, Dudas B, Balog E.
europepmc +1 more source
Optical Kerr Gating as a Strategy for Noise Reduction in Femtosecond Stimulated Raman Spectroscopy
Journal of Raman Spectroscopy, EarlyView.We report an experimental approach, where an Optical Kerr gate is incorporated with Femtosecond Stimulated Raman Spectrometry (FSRS). The gate functions as a temporal filter that preferentially suppresses the FSRS inherent background. FSRS spectra are reported with the Kerr‐gated methodology with significantly improved SNR compared to the conventional ...
Spyridon Kaziannis +5 more
wiley +1 more source
FDA-approved IMPDH inhibitors synergize with ribavirin to inhibit respiratory syncytial virus by interfering with purine <i>de novo</i> synthesis. [PDF]
Emerg Microbes InfectHu H +12 more
europepmc +1 more source
Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa +2 more
wiley +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Insulin secretion is a complex, vesicular transport process. Rab34 is a key regulator of intracellular vesicle transport; however, its role in insulin secretion has not yet been reported. miRNA‐9 is vital for the development and progression of the diagnosis and treatment of type 2 diabetes. This study aimed to investigate whether miR‐9 targets
Zhen‐Zhen Guo +5 more
wiley +1 more source