Results 141 to 150 of about 192,952 (216)

Flavonoids From Sophora tonkinensis Disrupt STING‐TBK1‐IRF3 Complex Assembly and Ameliorate Inflammatory Diseases by Modulating cGAS‐STING Signaling

Phytotherapy Research, EarlyView.
STF attenuates the activation of the cGAS‐STING pathway by blocking the interactions between STING and IRF3 as well as between STING and TBK1, thereby exerting therapeutic effects against inflammatory diseases. ABSTRACT cGAS‐STING pathway is a core regulator of innate immunity and inflammatory responses. Aberrant activation of the cGAS‐STING pathway is
Jincai Wen, Yuanyuan Guo, Yingjie Xu, Guirong Zhang, Xianling Wang, Sida Song, Jinming Liu, Yijin Liu, Qiaodi Liu, Yi Hao, Xiaoyan Zhan, Xiaohe Xiao, Zhaofang Bai   +12 more
wiley   +1 more source

Unveiling the KRAS Relationship between Affinity and Dynamics: A Molecular Simulations Study. [PDF]

J Chem Inf Model
Grundschober N, Dujmovic V, Oostenbrink C, Petrov D, Jandova Z, Bergner A, Galicia-Andrés E.   +6 more
europepmc   +1 more source

Effects of Green Tea Supplementation on Chemoprevention at Different Stages of Carcinogenesis: A Systematic Review

Phytotherapy Research, EarlyView.
ABSTRACT Green tea catechins have chemopreventive potential; however, the clinical evidence remains inconsistent. This review evaluated the effects of supplementation with green tea derivatives on chemoprevention at different stages of carcinogenesis. PubMed, Embase, Web of Science, Scopus, the Cochrane Library, CINAHL, and Google Scholar were searched
Thaís Moreira Machado, Mariene Garcia Gomes, Érika Yuri Hirose Murahara, Ana Lúcia Chalhoub Chediac Rodrigues, Ariane Nadolskis Severine, Thais Giovaninni Roberto, Sinara Laurini Rossato   +6 more
wiley   +1 more source

GTP hydrolysis-powered zinc metallochaperones as molecular switches. [PDF]

Curr Opin Chem Biol
Osterberg MK, McRae EM, Rocchio JS, Giedroc DP.   +3 more
europepmc   +1 more source

Gross Agricultural Emissions and Unequal Mitigation Pathways in the Brazilian Legal Amazon: Implications for Climate Justice and the Sustainable Development Goals

Sustainable Development, EarlyView.
ABSTRACT Climate mitigation policies in the Brazilian Legal Amazon have largely focused on aggregate or net emissions, providing limited evidence on how gross agricultural emissions reveal the intensity of productive emission sources independently of carbon removals.
Jorge Eduardo Macedo Simões, Marcelo Bentes Diniz, Márcia Jucá Texeira Diniz, Vanessa da Paixão Alves, Cynthia Simmons   +4 more
wiley   +1 more source

Structure and Function of Archaeal SRP54 Protein Mutants Associated with Human Severe Congenital Neutropenia. [PDF]

ACS Omega
Yang M, Brim AD, Long LF, Wu GC, Schlichting GM, Denard CA, Bruner SD.   +6 more
europepmc   +1 more source

Competitive SELEX Strategy for High‐Affinity Aptamer Isolation and Enhanced Biosensing

Small, EarlyView.
A novel competitive SELEX strategy was developed to isolate high‐affinity aptamers by using a lower‐affinity competitor during the selection process. This approach enabled the identification of an aptamer with exceptional binding affinity, significantly improving target detection sensitivity.
Jiuxing Li, Jiaxuan Xiao, Jimmy Gu, Zhen Zhang, Yingfu Li   +4 more
wiley   +1 more source

Design of an engineered Gα_q protein for high-yield expression and NMR isotope labeling in <i>E. coli</i>. [PDF]

Magn Reson Lett
Zhang Q, Yang J, Yan R, Hu Y.
europepmc   +1 more source

Molecular glues: Recent advances in cereblon substrate identification and mechanistic insights

Smart Molecules, EarlyView.
Molecular glues exert diverse core biological functions by inducing or stabilizing protein–protein interactions, extending far beyond the traditional scope of targeted protein degradation. Key breakthroughs include expanded cereblon substrate recognition, sustained G protein‐coupled receptor megacomplex signaling, and the first orthosteric molecular ...
Qingyun Guan, Xiaoyu Shi, Qian Yang, Xiangyi Jiang, Xinyong Liu, Peng Zhan   +5 more
wiley   +1 more source

ARHGAP40 suppresses clear cell renal cell carcinoma progression and is associated with altered glutamine-related metabolism and redox balance. [PDF]

Cancer Biol Ther
You N, Wang X, Wang C, Ma L, Lyu Y, Liu H, Yang F, Wang J, Zhang L, Wang J.   +9 more
europepmc   +1 more source