Lipid phosphate phosphatase 3 participates in transport carrier formation and protein trafficking in the early secretory pathway [PDF]
, 2013 The inhibition of phosphatidic acid phosphatase (PAP) activity by propanolol indicates that diacylglycerol (DAG) is required for the formation of transport carriers at the Golgi and for retrograde trafficking to the ER.
Alderton +77 more
core +2 more sources
Mitochondria-lysosome contacts regulate mitochondrial fission via Rab7 GTP hydrolysis
Nature, 2018 Both mitochondria and lysosomes are essential for maintaining cellular homeostasis, and dysfunction of both organelles has been observed in multiple diseases.
Y. Wong, Daniel Ysselstein, D. Krainc
semanticscholar +1 more source
Functional role of PGAM5 multimeric assemblies and their polymerization into filaments. [PDF]
, 2019 PGAM5 is a mitochondrial protein phosphatase whose genetic ablation in mice results in mitochondria-related disorders, including neurodegeneration. Functions of PGAM5 include regulation of mitophagy, cell death, metabolism and aging.
Agnew, Christopher +9 more
core +3 more sources
A study of the short and long-term regulation of E. coli metabolic pathways [PDF]
, 2011 The present study addresses the regulatory network of Escherichia coli and offers a global view of the short- and long-term regulation of its metabolic pathways.
Carneiro, S. +5 more
core +1 more source
Structural impact of GTP binding on downstream KRAS signaling†
Chemical Science, 2020 Oncogenic RAS proteins, involved in ∼30% of human tumors, are molecular switches of various signal transduction pathways. Here we apply a new protocol for the NMR study of KRAS in its (inactive) GDP- and (activated) GTP-bound form, allowing a ...
D. Menyhárd +5 more
semanticscholar +1 more source
Expression of the legume symbiotic lectin genes psl and gs52 promotes rhizobial colonization of roots in rice [PDF]
, 2005 Transgenic rice (Oryza sativa L. cv. Murasaki) carrying genes encoding pea (Pisum sativum) lectin (PSL) or wild-soybean (Glycine soja) lectin-nucleotide phosphohydrolase (GS52) were inoculated with Rhizobium leguminosarum bv.
Hernandez-Oane, R.J. +6 more
core +1 more source
Autophagy in the light of sphingolipid metabolism [PDF]
, 2015 Maintenance of cellular homeostasis requires tight and coordinated control of numerous metabolic pathways, which are governed by interconnected networks of signaling pathways and energy-sensing regulators.
Færgeman, Nils J. +2 more
core +2 more sources
Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases [PDF]
, 2002 BACKGROUND: The human genome contains at least 18 genes for Nudix hydrolase enzymes. Many have similar functions to one another. In order to understand their roles in cell physiology, these proteins must be characterised.
Leslie, Nick R +2 more
core +2 more sources
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Enzymes
British Journal of Pharmacology, Volume 176, Issue S1, Page S297-S396, December 2019., 2019 The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www ...
Stephen P H Alexander +39 more
wiley +1 more source
The Many Facets of Sphingolipids in the Specific Phases of Acute Inflammatory Response
Mediators of Inflammation, Volume 2018, Issue 1, 2018., 2018 This review provides an overview on components of the sphingolipid superfamily, on their localization and metabolism. Information about the sphingolipid biological activity in cell physiopathology is given. Recent studies highlight the role of sphingolipids in inflammatory process.
Sabine Grösch +3 more
wiley +1 more source