Results 21 to 30 of about 5,029 (135)

The human OPA1delTTAG mutation induces premature age-related systemic neurodegeneration in mouse [PDF]

, 2012
Dominant optic atrophy is a rare inherited optic nerve degeneration caused by mutations in the mitochondrial fusion gene OPA1. Recently, the clinical spectrum of dominant optic atrophy has been extended to frequent syndromic forms, exhibiting various ...
A.L. Mausset-Bonnefont, B. Chaix, C. Angebault Prouteau, C. Cazevieille, C. Delettre, C. Hamel, E. Sarzi, G. Bielicki, G. Lenaers, J. Wang, J.L. Puel, J.P. Renou, M. Seveno, N. Boddaert, N. Gueguen, P. Brabet, P. Reynier, V. Rigau   +17 more
core   +3 more sources

Detoxification and stress response genes expressed in a western North American bumble bee, Bombus huntii (Hymenoptera: Apidae) [PDF]

, 2013
BACKGROUND: The Hunt bumble bee (Bombus huntii Greene, Hymenoptera: Apidae) is a holometabolous, social insect important as a pollinator in natural and agricultural ecosystems in western North America.
Dennis L Welker, James P Strange, Junhuan Xu, Rosalind R James   +3 more
core   +1 more source

Systematic Production of Inactivating and NonInactivating Suppressor Mutations at the relA Locus That Compensate the Detrimental Effects of Complete spoT Loss and Affect Glycogen Content in Escherichia coli [PDF]

, 2014
In Escherichia coli, ppGpp is a major determinant of growth and glycogen accumulation. Levels of this signaling nucleotide are controlled by the balanced activities of the ppGpp RelA synthetase and the dual-function hydrolase/synthetase SpoT.
Almagro, Goizeder, Bahaji, Abdellatif, Bernal, Cristina, Bora Fernandez, Edurne, Canovas, Manuel, Codoñer, Francisco M., Eydallin, Gustavo, Lozano, Ana Belen, Montero, Manuel, Mori, Hirotada, Muñoz, Francisco Jose, Potueza Romeo, Javier, Rahimpour, Mehdi, Sevilla, Angel, Viale, Alejandro Miguel   +14 more
core   +9 more sources

Metal Fluorides as Analogs for Studies on Phosphoryl Transfer Enzymes [PDF]

, 2017
The 1994 structure of a transition state analog with AlF4- and GDP complexed to G1, a small G protein, heralded a new field of research into structure and mechanism of enzymes that manipulate transfer of the phosphoryl (PO3-) group.
Admiraal, Anderson, Antony, Batsanov, Baur, Baxter, Baxter, Baxter, Baxter, Berente, Bigay, Blackburn, Blackburn, Bock, Boone, Bowler, Bruice, Brunk, Burgos, Cavalli, Cleland, Cliff, Coleman, Du, Field, Fisher, Fovet, Frey, Geerlings, Graham, Graham, Griffin, Grigorenko, Grigorenko, Hemsworth, Henry, Higashijima, Hilbert, Himo, Hoffman, Hur, Issartel, Jackson, Jin, Jin, Jin, Kamerlin, Khrenova, Klink, Klähn, Knowles, Kowalinski, Lahiri, Lassila, Leigh, Lienhard, Liu, Lowe, Madhusudan, Maegley, Marcos, Martin, Martin, Maruta, Mesmer, Mildvan, Oldfield, Park, Pauling, Plotnikov, Praefcke, Prasad, Pylypenko, Pérez-Gallegos, Pérez-Gallegos, Ribeiro, Rittinger, Scheffzek, Schlichting, Schlichting, Senn, Sheftic, Shinoda, Shurki, Siegbahn, Smith, Sondek, Sośnicki, Sternweis, Thorsell, Topol, Toyoshima, Valiev, Wang, Warshel, Webster, Wolfenden, Zhang   +97 more
core   +5 more sources

Essential Roles for Mycobacterium tuberculosis Rel beyond the Production of (p)ppGpp [PDF]

, 2013
In Mycobacterium tuberculosis, the stringent response to amino acid starvation is mediated by the M. tuberculosis Rel (Rel(Mtb)) enzyme, which transfers a pyrophosphate from ATP to GDP or GTP to synthesize ppGpp and pppGpp, respectively.
Stallings, Christina L., Weiss, Leslie A.   +1 more
core   +2 more sources

Functional role of PGAM5 multimeric assemblies and their polymerization into filaments. [PDF]

, 2019
PGAM5 is a mitochondrial protein phosphatase whose genetic ablation in mice results in mitochondria-related disorders, including neurodegeneration. Functions of PGAM5 include regulation of mitophagy, cell death, metabolism and aging.
Agnew, Christopher, Frost, Adam, Herrera, Clara, Ingaramo, Maria, Jura, Natalia, Miller-Vedam, Lakshmi, Ruiz, Karen, Thaker, Tarjani M, Toso, Daniel, Trenker, Raphael   +9 more
core   +3 more sources

A study of the short and long-term regulation of E. coli metabolic pathways [PDF]

, 2011
The present study addresses the regulatory network of Escherichia coli and offers a global view of the short- and long-term regulation of its metabolic pathways.
Carneiro, S., Ferreira, E. C., Lourenço, Anália, Pinto, José P., Rocha, I., Rocha, Miguel   +5 more
core   +1 more source

Lipid phosphate phosphatase 3 participates in transport carrier formation and protein trafficking in the early secretory pathway [PDF]

, 2013
The inhibition of phosphatidic acid phosphatase (PAP) activity by propanolol indicates that diacylglycerol (DAG) is required for the formation of transport carriers at the Golgi and for retrograde trafficking to the ER.
Alderton, Ambroggio, Antony, Asp, Bard, Baron, Bechler, Beck, Ben-Tekaya, Ben-Tekaya, Billah, Brindley, Brindley, Brown, Burger, Cabrera, Carrasco, de Figueiredo, Dejgaard, Escalante-Alcalde, Fernández-Ulibarri, Grigoriev, Grigoriev, Grimsey, Hammond, Henneberry, Ho, Huijbregts, Humtsoe, Jackson, Jasinska, Johannes, Kai, Kai, Kano, Kearns, Klumperman, Kooijman, Krauss, Lev, Lippincott-Schwartz, Litvak, Long, Long, Martinez, Martínez-Alonso, Meier, Morikawa, Morris, Mérida, Nagaya, Nilsson, Pappu, Pyne, Pyne, Roberts, Rohde, Roth, Roux, San Pietro, Saraste, Sarri, Schindler, Schmidt, Sciorra, Shemesh, Sigal, Sorre, Subathra, Tian, Ulrix, van Meer, Villani, Waggoner, White, Yang, Yang, Zhang   +77 more
core   +2 more sources

Expression of the legume symbiotic lectin genes psl and gs52 promotes rhizobial colonization of roots in rice [PDF]

, 2005
Transgenic rice (Oryza sativa L. cv. Murasaki) carrying genes encoding pea (Pisum sativum) lectin (PSL) or wild-soybean (Glycine soja) lectin-nucleotide phosphohydrolase (GS52) were inoculated with Rhizobium leguminosarum bv.
Hernandez-Oane, R.J., Ladha, J.K., Reddy, P.M., So, R.B., Sreevidya, V.S., Stacey, G., Sullia, S.B.   +6 more
core   +1 more source

Autophagy in the light of sphingolipid metabolism [PDF]

, 2015
Maintenance of cellular homeostasis requires tight and coordinated control of numerous metabolic pathways, which are governed by interconnected networks of signaling pathways and energy-sensing regulators.
Færgeman, Nils J., Harvald, Eva Bang, Olsen, Anne Sofie Braun   +2 more
core   +2 more sources