Results 21 to 30 of about 4,762 (95)

Cellular Metabolic Network Analysis: Discovering Important Reactions in Treponema pallidum

BioMed Research International, Volume 2015, Issue 1, 2015., 2015
T. pallidum, the syphilis‐causing pathogen, performs very differently in metabolism compared with other bacterial pathogens. The desire for safe and effective vaccine of syphilis requests identification of important steps in T. pallidum’s metabolism. Here, we apply Flux Balance Analysis to represent the reactions quantitatively. Thus, it is possible to
Xueying Chen, Min Zhao, Hong Qu, Md. Altaf-Ul-Amin   +3 more
wiley   +1 more source

Metabolic Origin, Role and Fate of the Denaturant Guanidine

Microbial Biotechnology, Volume 18, Issue 11, November 2025.
The origin of metabolic guanidine is largely a mystery. We suggest it is created when guanine‐containing nucleotides are oxidised by molecular oxygen instead of being broken down into urea as purines normally would. Guanidine may act as a signal to help cells control the level of reactive oxygen species.
Antoine Danchin, Victor de Lorenzo, Pablo Iván Nikel, Conghui You   +3 more
wiley   +1 more source

Clinical Trial of Human Fetal Brain‐Derived Neural Stem/Progenitor Cell Transplantation in Patients with Traumatic Cervical Spinal Cord Injury

Neural Plasticity, Volume 2015, Issue 1, 2015., 2015
In a phase I/IIa open‐label and nonrandomized controlled clinical trial, we sought to assess the safety and neurological effects of human neural stem/progenitor cells (hNSPCs) transplanted into the injured cord after traumatic cervical spinal cord injury (SCI).
Ji Cheol Shin, Keung Nyun Kim, Jeehyun Yoo, Il-Sun Kim, Seokhwan Yun, Hyejin Lee, Kwangsoo Jung, Kyujin Hwang, Miri Kim, Il-Shin Lee, Jeong Eun Shin, Kook In Park, Young Wook Yoon   +12 more
wiley   +1 more source

The Malignant Transformation of Viral Hepatitis to Hepatocellular Carcinoma: Mechanisms and Interventions

MedComm, Volume 6, Issue 3, March 2025.
The malignant transformation from chronic viral hepatitis to hepatocellular carcinoma (HCC) involves intricate interactions among viral, host, and environmental factors. Key drivers of this transformation include viral integration, genomic instability, epigenetic modifications, oxidative stress, gut microbiota dysbiosis, chronic inflammation, immune ...
Huimin Yuan, Ruochen Xu, Senlin Li, Mengzhu Zheng, Qingyi Tong, Ming Xiang, Yonghui Zhang   +6 more
wiley   +1 more source

Adenosine A1 agonists and the Ca2+ channel agonist bay K 8644 produce a synergistic stimulation of the GTPase activity of Go in rat frontal cortical membranes

The identity and role of G proteins in coupling adenosine receptors to effectors have been studied to a limited degree. We have identified the G proteins whose GTPase activity is stimulated by adenosine receptor agonists in neuronal membranes.

core   +1 more source

Biochemical effects of phosphite on the phytopathogenicity of Phytophthora cinnamomi Rands

, 2012
Phosphite, a chemical analogue of orthophosphate, controls disease symptoms and spread of Oomycete plant pathogens, particularly those caused by Phythophthora spp.
Stasikowski, Patricia
core  

Protein Engineering-Enabled Cryo-EM Investigation of Small GTPases. [PDF]

J Mol Biol
Hu Z, Patel UR, Glasser E, Koide A, Koide S.   +4 more
europepmc   +1 more source

Clinical outcomes of genomically guided trametinib monotherapy across cancer types: results from the IMPRESS-Norway trial. [PDF]

Acta Oncol
Slørdahl KS, Puco K, Falk RS, Dyvik I, Brabrand S, Niehusmann P, Steinskog ESS, Blix ES, Flobak Å, Oppedal IA, Meltzer S, Torkildsen CF, Blakstad H, Lindemann K, Smeland S, Amundsen A, Taskén K, Helland Å, InPred Consortium.   +18 more
europepmc   +1 more source

Allosteric targeting with antiviral nucleotide analogs allows fine-tuning of SAMHD1 dNTPase activity. [PDF]

J Biol Chem
Dirks C, Schlotterbeck AK, Pettersson P, Leppert A, Landreh M, Zhang SM, Rudd SG.   +6 more
europepmc   +1 more source

Single-step in vitro reconstitution of the <i>Escherichia coli</i> ribosome mediated by two GTPase factors, EngA and ObgE. [PDF]

Elife
Sato A, Lai WY, Sakai Y, Masuda K, Shimizu Y.   +4 more
europepmc   +1 more source