Results 31 to 40 of about 54,635 (165)

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Enzymes

British Journal of Pharmacology, Volume 174, Issue S1, Page S272-S359, December 2017., 2017
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand ...
Stephen PH Alexander, Doriano Fabbro, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies, CGTP Collaborators   +11 more
wiley   +1 more source

The speed of GTP hydrolysis determines GTP cap size and controls microtubule stability

bioRxiv, 2019
Microtubules are bistable cytoskeletal polymers whose function depends on their property to switch between states of growth and shrinkage 1. Growing microtubules are thought to be stabilized by a GTP cap at their ends 2-5. The nature of this cap, however,
Johanna Roostalu, Claire Thomas, N. Cade, S. Kunzelmann, I. Taylor, T. Surrey   +5 more
semanticscholar   +1 more source

Proteomic Analysis of Stage‐II Breast Cancer from Formalin‐Fixed Paraffin‐Embedded Tissues

BioMed Research International, Volume 2016, Issue 1, 2016., 2016
Breast cancer is the most frequently occurring disease among women worldwide. The early stage of breast cancer identification is the key challenge in cancer control and prevention procedures. Although gene expression profiling helps to understand the molecular mechanism of diseases or disorder in the living system, gene expression pattern alone is not ...
Naif Abdullah Al-Dhabi, Srisesharam Srigopalram, Soundharrajan Ilavenil, Young Ock Kim, Paul Agastian, Rajasekhar Baaru, Kannan Balamurugan, Ki Choon Choi, Mariadhas Valan Arasu, Gagan Deep   +9 more
wiley   +1 more source

A homologue of the Parkinson’s disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover

Nature Communications, 2017
Mutations in LRRK2 are a common cause of genetic Parkinson’s disease (PD). LRRK2 is a multi-domain Roco protein, harbouring kinase and GTPase activity. In analogy with a bacterial homologue, LRRK2 was proposed to act as a GTPase activated by dimerization
E. Deyaert, Lina Wauters, G. Guaitoli, A. Konijnenberg, Margaux Leemans, S. Terheyden, Arsen Petrovic, R. Gallardo, L. Nederveen-Schippers, P. S. Athanasopoulos, Henderikus Pots, P. V. van Haastert, F. Sobott, C. Gloeckner, R. Efremov, A. Kortholt, W. Versées   +16 more
semanticscholar   +1 more source

The Proteome and Lipidome of Thermococcus kodakarensis across the Stationary Phase

Archaea, Volume 2016, Issue 1, 2016., 2016
The majority of cells in nature probably exist in a stationary‐phase‐like state, due to nutrient limitation in most environments. Studies on bacteria and yeast reveal morphological and physiological changes throughout the stationary phase, which lead to an increased ability to survive prolonged nutrient limitation.
Emma J. Gagen, Marcos Y. Yoshinaga, Franka Garcia Prado, Kai-Uwe Hinrichs, Michael Thomm, Haruyuki Atomi   +5 more
wiley   +1 more source

Small GTPases and formins in mammalian oocyte maturation: cytoskeletal organizers [PDF]

, 2011
The maturation process of mammalian oocytes accompanies an extensive rearrangement of the cytoskeleton and associated proteins. As this process requires a delicate interplay between the cytoskeleton and its regulators, it is often targeted by various ...
Azoury, Bartolini, Bielak-Zmijewska, Bione, Brunet, Brunet, Burkel, Carabatsos, Chesarone, Compton, Cui, Deng, Dumont, Faix, Gueth-Hallonet, Halet, Hamel, Hamel, Hassold, Hunt, Kato, Lammers, Lammers, Leader, Li, Lynch, Lénárt, Manseau, Na, Riedl, Schuh, Schuh, Van Aelst, Verlhac, Wood   +34 more
core   +2 more sources

Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers

Cancer Discovery
Broad-spectrum inhibition of RAS-GTP with RMC-6236 is active and tolerated at exposures that induce profound tumor regressions in preclinical models of RAS-driven cancers and that can be associated with objective responses in patients with such cancers.
Jingjing Jiang, Lingyan Jiang, Benjamin J. Maldonato, Yingyun Wang, M. Holderfield, Ida Aronchik, Ian P. Winters, Zeena Salman, Cristina Blaj, Marie Ménard, Jens Brodbeck, Zhe Chen, Xing Wei, Michael J Rosen, Y. Gindin, Bianca J Lee, James W Evans, Stephanie Chang, Zhican Wang, Kyle Seamon, Dylan Parsons, J. Cregg, Abby Marquez, A. Tomlinson, Jason K. Yano, J. E. Knox, Elsa Quintana, Andrew J. Aguirre, K. Arbour, Abby Reed, W. C. Gustafson, Adrian L Gill, E. Koltun, D. Wildes, J. Smith, Zhengping Wang, Mallika Singh   +36 more
semanticscholar   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Cellular Metabolic Network Analysis: Discovering Important Reactions in Treponema pallidum

BioMed Research International, Volume 2015, Issue 1, 2015., 2015
T. pallidum, the syphilis‐causing pathogen, performs very differently in metabolism compared with other bacterial pathogens. The desire for safe and effective vaccine of syphilis requests identification of important steps in T. pallidum’s metabolism. Here, we apply Flux Balance Analysis to represent the reactions quantitatively. Thus, it is possible to
Xueying Chen, Min Zhao, Hong Qu, Md. Altaf-Ul-Amin   +3 more
wiley   +1 more source

The plant Nudix hydrolase family. [PDF]

, 2008
Nudix hydrolases are a family of proteins defined by a conserved amino-acid sequence GX(5)-EX(7)REUXEEXGU, where U is a hydrophobic residue. These enzymes are widely distributed among all classes of organisms and catalyze, with varying degrees of ...
Kraszewska, Elzbieta
core