The enzymes of human diphosphoinositol polyphosphate metabolism
The FEBS Journal, Volume 281, Issue 1, Page 14-33, January 2014., 2014 This review covers the three classes of enzymes involved in the metabolism of diphosphoinositol polyphosphates – inositol hexakisphosphate kinases (IP6K), inositol hexakisphosphate and diphosphoinositol‐pentakisphosphate kinases (PPIP5K), and diphosphoinositol polyphosphate phosphohydrolases (DIPP).
Mark P. Thomas, Barry V. L. Potter
wiley +1 more source
IMP/GTP balance modulates cytoophidium assembly and IMPDH activity
Cell Division, 2018 Inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme in de novo GTP biosynthesis, plays an important role in cell metabolism and proliferation.
G. D. Keppeke +8 more
semanticscholar +1 more source
A Plasma Metabolomic Signature Involving Purine Metabolism in Human Optic Atrophy 1 (OPA1)-Related Disorders [PDF]
, 2018 Purpose: Dominant optic atrophy (DOA; MIM [Mendelian Inheritance in Man] 165500), resulting in retinal ganglion cell degeneration, is mainly caused by mutations in the optic atrophy 1 (OPA1) gene, which encodes a dynamin guanosine triphosphate (GTP)ase ...
A. Chevrollier +16 more
core +2 more sources
GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2
Human Molecular Genetics, 2017 Mutations in leucine-rich repeat kinase 2 (LRRK2) comprise the most common cause of familial Parkinson's disease (PD), and sequence variants modify risk for sporadic PD. Previous studies indicate that LRRK2 interacts with microtubules (MTs) and alters MT-
Marian Blanca Ramírez +10 more
semanticscholar +1 more source
Evolutionary consequences of a large duplication event in Trypanosoma brucei: Chromosomes 4 and 8 are partial duplicons [PDF]
, 2007 Background Gene order along the genome sequence of the human parasite Trypanosoma brucei provides evidence for a 0.5 Mb duplication, comprising the 3' regions of chromosomes 4 and 8.
Jackson, Andrew P
core +3 more sources
Nature Methods, 2017 GTP is a major regulator of multiple cellular processes, but tools for quantitative evaluation of GTP levels in live cells have not been available. We report the development and characterization of genetically encoded GTP sensors, which we constructed by
A. Bianchi-Smiraglia +16 more
semanticscholar +1 more source
Make and Break the Alarmone:regulation of (p)ppGpp Synthetase/Hydrolase Enzymes in Bacteria [PDF]
, 2019 Bacteria use dedicated mechanisms to respond adequately to fluctuating environments and to optimize their chances of survival in harsh conditions. One of the major stress responses used by virtually all bacteria relies on the sharp accumulation of an ...
Hallez, Régis, Ronneau, Séverin
core +1 more source
Standardized mitochondrial analysis gives new insights into mitochondrial dynamics and OPA1 function [PDF]
, 2012 Mitochondria form dynamic tubular networks through processes of fission and fusion. Defect in mitochondrial dynamics lead to various pathologies, including several common and some rare neurodegenerative disorders.
A. Chevrollier +9 more
core +3 more sources
A multidrug ABC transporter with a taste for GTP
Scientific Reports, 2018 During the evolution of cellular bioenergetics, many protein families have been fashioned to match the availability and replenishment in energy supply. Molecular motors and primary transporters essentially need ATP to function while proteins involved in ...
C. Orelle +9 more
semanticscholar +1 more source
5'-nucleotidases, nucleosides and their distribution in the brain: pathological and therapeutic implications [PDF]
, 2013 Elements of the nucleoside system (nucleoside levels, 5'-nucleotidases (5'NTs) and other nucleoside metabolic enzymes, nucleoside transporters and nucleoside receptors) are unevenly distributed in the brain, suggesting that nucleosides have region ...
Dobolyi, Árpád +3 more
core