Structural Basis for Ligand Binding to the Guanidine-I Riboswitch.
C. Reiss, Y. Xiong, S. Strobel
semanticscholar +1 more source
Nanoscopic Mapping of the Extracellular Space in Amyloid Plaque‐rich Cortex
The extracellular space and diffusion around amyloid plaques are examined using shadow imaging and single‐particle tracking. Increased diffusivity is found near plaques, extracellular matrix alterations, and plaque core penetrability that varies with amyloid phenotype.
Juan Estaún‐Panzano +11 more
wiley +1 more source
Abstract INTRODUCTION Alzheimer's disease (AD) has been regarded as a brain‐first disorder. Emerging evidence suggests that the gut may influence central nervous system pathology, but the mechanisms remain unclear. METHODS We conducted a proteomic and microbial analysis of transverse colon samples from clinically and pathologically confirmed AD and ...
Qiwen Cheng +6 more
wiley +1 more source
Engineering of High‐Yield Recombinant Adeno‐Associated Virus Producer Plasmids
Graphical Abstract and Lay Summary Recombinant adeno‐associated viruses (AAV) are important in gene therapy but their production may be impaired by non‐optimized gene design. In this study, the authors demonstrate that production was best when the AAV replicase gene was in a wild‐type configuration while the complexity of other genetic elements could ...
Marco T. Radukic +10 more
wiley +1 more source
Novel guanidine derivatives as mechanistic scaffolds for anticancer agents: synthesis, characterization, DNA-binding, and computational studies. [PDF]
Zaman H +6 more
europepmc +1 more source
Reviewer #1 (Public Review): Single-molecule Ligand Response of Guanidine-IV riboswitch
Lingzhi Gao, Dian Chen, Yu Liu
openalex +1 more source
Thermal Induced Changes in Cuticle and Cortex to Chemically Treated Hair
ABSTRACT The deterioration of the cuticle and cortex hair due to routine cosmetic practices has been identified as a primary factor contributing to undesirable changes in the esthetic qualities of hair. Chemical and physical treatments can cause significant damage to hair fibers.
C. R. R. C. Lima +4 more
wiley +1 more source
<i>E.coli</i>-derived CsgA-peptides stimulate cytokine production in microglia and lead to transient changes in neocortical Aβ-levels in pre-plaque <i>APP</i> <sub><i>SWE</i></sub> <i>/PS1</i> <sub><i>ΔE9</i></sub> and <i>wild type</i> mice. [PDF]
Mygind L +11 more
europepmc +1 more source

