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The physiological role of guanidinoacetic acid and its relationship with arginine in broiler chickens

open access: yesPoultry Science, 2021
: The role of guanidinoacetic acid (GAA) and its relationship with arginine was reviewed in order to define a replacement ratio between GAA and arginine for broiler diet formulation, the ratio being of how much arginine could be spared, or replaced by ...
Naheeda Portocarero, Ulrike Braun
exaly   +2 more sources

Guanidinoacetic acid supplementation improves feed conversion in broilers subjected to heat stress associated with muscle creatine loading and arginine sparing

open access: yesPoultry Science, 2020
It was hypothesized that dietary guanidinoacetic acid (GAA), the precursor of creatine (Cr), would be beneficial to heat-stressed finisher broilers owing to improved cellular energy status and arginine sparing effects.
A Lemme, A Golian, H Kermanshahi
exaly   +3 more sources
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Impaired Metabolism of Guanidinoacetic Acid in Uremia

Nephron, 2008
In order to investigate the guanidinoacetic acid (GAA) metabolism in uremia, we have measured serum guanidino compounds in patients with chronic renal failure (CRF) in comparison with normal subjects, and the renal content of GAA and glycine amidinotransferase (GAT) activity in the kidney of experimental CRF rabbits.
Y, Tofuku   +3 more
openaire   +2 more sources

A new enzymatic assay of urinary guanidinoacetic acid

Clinica Chimica Acta, 1991
We describe a new enzymatic determination of urinary guanidinoacetic acid (GAA) with guanidinoacetate kinase (ATP: guanidinoacetate N-phosphotransferase, EC 2.7.3.1), which does not require a blank to correct for endogenous constituents (ADP and pyruvate).
Y, Shirokane, M, Nakajima, K, Mizusawa
openaire   +2 more sources

Advanced physiological roles of guanidinoacetic acid

European Journal of Nutrition, 2015
Dietary guanidinoacetic acid (GAA) seems to improve cellular bioenergetics by stimulating creatine biosynthesis. However, GAA could have other biological functions that might affect its possible use as a food ingredient in human nutrition. In this paper, we identified several alternative physiological roles of supplemental GAA, including the ...
openaire   +2 more sources

Guanidinoacetic acid as a performance-enhancing agent

Amino Acids, 2015
Guanidinoacetic acid (GAA; also known as glycocyamine or guanidinoacetate) is the natural precursor of creatine, and under investigation as a novel dietary agent. It was first identified as a natural compound in humans ~80 years ago. In the 1950s, GAA's use as a therapeutic agent was explored, showing that supplemental GAA improved patient-reported ...
openaire   +2 more sources

Oxidant-Antioxidant Capacity of Dietary Guanidinoacetic Acid

Annals of Nutrition and Metabolism, 2015
<b><i>Background/Aims:</i></b> Guanidinoacetic acid (GAA) is an experimental nutritional additive under the functional group amino acids and derivatives, yet its use in human nutrition is hindered by limited data on GAA safety. In this double blind, placebo-controlled pilot study, we evaluated the effects of dietary GAA (3 g/day)
Sergej M. Ostojic   +2 more
openaire   +2 more sources

Human gut microbiota as a source of guanidinoacetic acid

Medical Hypotheses, 2020
Guanidinoacetic acid (GAA) is a natural amino acid derivative that acts as a precursor of creatine while being synthesized and utilized in a two-step reaction that takes place in the human kidney and liver. In this paper, we have proposed that guanidinoacetase, an enzyme present in healthy gut microbiota, might contribute to gross GAA turnover by ...
openaire   +2 more sources

Cellular bioenergetics of guanidinoacetic acid: the role of mitochondria

Journal of Bioenergetics and Biomembranes, 2015
Guanidinoacetic acid (GAA) is a natural precursor of creatine, and a possible substrate for the creatine kinase (CK) enzyme system, serving as a creatine mimetic. Its direct role in cellular bioenergetics has been confirmed in several studies, however GAA utilization by CK seems to be a second-rate as compared to creatine, and compartment-dependent ...
openaire   +2 more sources

Biosynthesis of guanidinoacetic acid. I. Purification and properties of transamidinase

Archives of Biochemistry and Biophysics, 1956
Abstract A transamidinase which catalyzes the reversible reaction, l -arginine + glycine guanidinoacetic acid + l -ornithine, has been obtained from hog kidney and purified about 80-fold. Ornithine exerts a strong product inhibition which influences the reaction rates; conditions are given for obtaining initial rates.
S, RATNER, O, ROCHOVANSKY
openaire   +2 more sources

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