Results 91 to 100 of about 158,534 (314)
Beyond Structure: Methylation Fine‐Tunes Stability and Folding Kinetics of bcl2Mid G‐Quadruplex
Angewandte Chemie, EarlyView.The introduction of a single 5‐methylcytosine into a G‐rich sequence originating from the B‐cell lymphoma 2 (BCL2) gene promoter affects both the folding kinetics and thermodynamics of the two G4 structures and thus plays a crucial role in regulating G4 folding pathways, which has significant implications for the control of gene expression.
Nataša Medved +5 more
wiley +2 more sources
Advanced Science, EarlyView.An intelligent DNA nanomachine based on DNA tetrahedron is proposed, incorporated with aptamer and specific miRNA‐responsive hairpin catalytic assembly (HCA), for precise therapy of cutaneous squamous cell carcinoma (cSCC) in mice, with barely systemic toxicity and inflammation.
Hanane Aliouat +9 more
wiley +1 more source
The Diverse Modes of Oxygen Reactivity in Life & Chemistry
ChemSusChem, Volume 15, Issue 24, December 20, 2022., 2022 Breath of life: Oxygen is the quintessential molecule of life on our planet. Three molecular oxygen species dominate natural and artificial oxygenation reactions: the singlet and triplet spin states of dioxygen and ozone. This Review summarizes key applications of these molecular oxygen species in biology, medicine, technologies, and laboratories ...
Robin Stuhr +2 more
wiley +1 more source
Acta Dermato-Venereologica, 2020 DNA damage and oxidative stress play a critical role in photoageing. Seborrhoeic keratosis (SK) affects sunlight-exposed sites in aged individuals. This study examined the mechanism of photoageing in SK.
Kyung Ah Cheong, Ai-Young Lee
doaj +1 more source
THEORETICAL STUDY OF THE NON-WATSON-CRICK BASE PAIR GUANINE-GUANINE [PDF]
Journal of the Chilean Chemical Society, 2010 ABSTRACT A theoretical study of the non canonical base pair, Guanine-Guanine (G-G) has been carried out in the frame of molecular orbital theory using density functional theory (DFT). The Becke three parameter hybrid including correlation functional that contains local and non-local terms (B3LYP) was used thoroughly.
MADARIAGA, S. TERESA +1 more
openaire +2 more sources
High Sugar Induced RCC2 Lactylation Drives Breast Cancer Tumorigenicity Through Upregulating MAD2L1
Advanced Science, EarlyView.This study finds that KAT2A mediates the lactylation modification of the non‐histone protein RCC2 at K124, facilitating the recruitment of free SERBP1 and aiding in the formation of the initial SERBP1‐MAD2L1 complex. SERBP1 enhances the stability of MAD2L1 mRNA and promotes cellular proliferation.
Bowen Zheng +11 more
wiley +1 more source
Energetics of holes trapped in DNA [PDF]
arXiv, 2005 We report on our study of the electronic properties of guanine traps in the DNA surrounded by adenines. We have shown that for a typical range of DNA parameters, formation of the bound state of two holes at the same guanine trap is possible for the GGG and GGGG traps if the hole-hole interaction is weak, which can be achieved for the DNA in solutions ...
arxiv
Advanced Science, EarlyView.Based on the poor cartilage penetration of tFNA, a novel tFNA‐2WL with excellent cartilage permeability and perfect chondrocyte endocytosis properties is designed and fabricated. As a result, tFNA‐2WL has a nearly seven‐fold increase in the penetration depth into the cartilage, with the same excellent cell entry properties as tFNA.
Kui Huang +9 more
wiley +1 more source
Metal‐free phthalimide‐labeled peptide nucleic acids for electrochemical biosensing applications
Electrochemical Science Advances, Volume 2, Issue 6, December 2022., 2022 Abstract Peptide nucleic acids (PNAs) are neutral mimics of natural DNA and RNA biopolymers that have caught the attention of researchers working on the identification of specific sequences of nucleobases in DNA/RNA strands. For this purpose, specific analytical protocols need to be developed to optimize the nucleic acid recognition ability of PNAs ...
Mirko Magni +5 more
wiley +1 more source
Enol form of uracil in the GU "wobble" pair. NMR evidence [PDF]
arXiv, 2012 GU "wobble" pair may contain either the enol form of uracil and the keto form of guanine or the enol form of guanine and the keto form of uracil. A direct proof of uracil existence in enol form can be obtained by using NMR spectroscopy. In HNN-COSY experiments the GU pair imitates the GC pair due to the enolization of uracil.
arxiv