Results 111 to 120 of about 191,107 (300)

GMPS (guanine monphosphate synthetase) [PDF]

, 2000
Review on GMPS (guanine monphosphate synthetase), with data on DNA, on the protein encoded, and where the gene is ...
Huret, JL
core   +1 more source

Ligand‐Defined Interfacial Chemistry Enables Instant and Sequence‐General DNA Chemisorption on Gold Nanoparticles Toward Label‐Free SERS With Single‐Base Resolution

Advanced Science, EarlyView.
Ascorbic Acid‐Engineered Interface Enables Universal DNA Functionalization on Gold Nanoparticles: Attenuating electrostatic repulsion and leveraging synergistic hydrogen‐bonding interactions significantly lowers the kinetic barrier for DNA adsorption, enabling rapid and sequence‐general functionalization of non‐thiolated DNA‐requiring only a single ...
Guangping Li, Cheng Wang, Xinyue Wu, Zhongxiang Ding, Heng Gao, Zhonggang Liu, Yu Zhang, Jinai Chen, Feng Wang, Honglin Liu   +9 more
wiley   +1 more source

Generation, repair and replication of guanine oxidation products

Genes and Environment, 2017
Guanine is the most readily oxidized of the four DNA bases, and guanine oxidation products cause G:C-T:A and G:C-C:G transversions through DNA replication.
Katsuhito Kino, Masayo Hirao-Suzuki, Masayuki Morikawa, Akane Sakaga, Hiroshi Miyazawa   +4 more
doaj   +1 more source

Cloning, expression, purification and drug targeting of Plasmodium falciparum hypoxanthine guanine xanthine phosphoribosyltransferase (HGXPRT)

, 2005
Includes bibliographical references.The research concerns sub-cloning the gene for HGXPRT from Plasmodium falciparum from a vector with a His-tag facility to one without, expression of the protein in E. coli, and purification.
Mbewe, Boniface
core  

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study

Clinics, 2019
OBJECTIVE: In this study, the relationship between osteoporotic vertebral fractures and 9041 Guanine/Adenine and 3673 Guanine/Adenine polymorphisms related to the vitamin K epoxide reductase complex subunit-1 (VKORC1) gene in postmenopausal women with ...
Merih Ozgen, Didem Turgut Cosan, Fulya Doganer, Ahu Soyocak, Onur Armagan, Selen Kuzgun, Ayse Merve Aydogan, Hasan Veysi Gunes, Irfan Degirmenci, Fezan Mutlu   +9 more
doaj   +1 more source

A General Enzymatic Strategy for Site‐Specific Incorporation of Modified Genetic Building Blocks Into DNA

Advanced Science, EarlyView.
Eco‐friendly enzymatic synthesis of high‐fidelity, site‐specifically modified DNA using 3′‐blocked nucleotides for full synthetic control and next‐generation sequencing compatibility. ABSTRACT Methods for site‐specific incorporation of modified DNA building blocks remain limited.
Raveena Raveena, Bhavana Ramadas, Sidney Becker   +2 more
wiley   +1 more source

Confinement-Controlled Crystallization of Guanine

Guanine crystals are frequently encountered in nature in the β-polymorph to create structural colors, to enhance the vision of creatures, and for camouflage. Unfortunately, it is challenging to control the crystallization of guanine in aqueous conditions
Wittig, Nina Kølln, Køppen Christensen, Thorbjørn Erik, Ostergaard, Maja, Garrevoet, Jan, Amstad, Esther, Østergaard, Maja, Birkedal, Henrik, Li, Chuen Ru, Christensen, Thorbjorn Erik Koppen, Wittig, Nina Kolln, Li, Chuen-Ru   +10 more
core   +1 more source

Guanine-requiring mutants

, 1979
Guanine-requiring ...
Yoder, O. C., O. C. Yoder
core   +1 more source