Results 1 to 10 of about 220,231 (169)
Novel Adenine–Hydrazone Hybrids Against Human Lung Adenocarcinoma (A549): Design, Synthesis, Cellular Mechanistic Investigation and Molecular Docking Studies [PDF]
PharmaceuticalsBackground/Objectives: Adenine derivatives are promising anticancer scaffolds, but their cellular mechanisms remain unclear. This study aimed to synthesize adenine–hydrazone hybrids and evaluate their cytotoxic effects in human lung adenocarcinoma (A549)
Emre Menteşe +5 more
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Frontiers in Pharmacology, 2022 CKD is a clinical syndrome with slow development and gradual deterioration of renal function. At present, modern medicine still lacks an ideal treatment method for this disease, while TCM has accumulated rich clinical experience in the treatment of CKD ...
Ling Wang +10 more
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Effect of fetuin-A on adenine-induced chronic kidney disease model in male rats [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): This study aimed to investigate the possible effects of fetuin-A on an adenine-induced chronic kidney disease (CKD) model in male rats.
Wesam Ashour +3 more
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Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity [PDF]
International Journal for Parasitology: Drugs and Drug Resistance, 2014 African trypanosomes, like all obligate parasitic protozoa, cannot synthesize purines de novo and import purines from their hosts to build nucleic acids. The purine salvage pathways of Trypanosoma brucei being redundant, none of the involved enzymes is likely to be essential.
Lüscher, Alexandra +4 more
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Alteration in the molecular structure of the adenine base exposed to gamma irradiation: An ESR study
Open Chemistry, 2023 Adenine polycrystals were obtained from their powder form under effective crystallization conditions by adjustment of the concentration of chemical solutions. The adenine samples were irradiated with a 60Co gamma-ray source at room temperature for 12, 24,
Usta Keziban
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Silver SERS Adenine Sensors with a Very Low Detection Limit
Biosensors, 2020 The detection of adenine molecules at very low concentrations is important for biological and medical research and applications. This paper reports a silver-based surface-enhanced Raman scattering (SERS) sensor with a very low detection limit for adenine
Yonhua Tzeng, Bo-Yi Lin
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Molbank, 2022 6-Amino-3-(prop-2-en-1-yl)-9H-purin-3-ium tetracopper(I) hexabromide [(C5H5N5(C3H5))2Cu4Br6] (1) is synthesized in this paper. The title compound is characterized by Raman spectroscopy and single crystal X-ray diffraction: monoclinic, Sp.gr. P21/c, Z = 2,
Oleksiy V. Pavlyuk +3 more
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Biomedicines, 2022 Glioblastoma (GBM) is a lethal brain cancer exhibiting high levels of drug resistance, a feature partially imparted by tumor cell stemness. Recent work shows that homozygous MTAP deletion, a genetic alteration occurring in about half of all GBMs ...
Simranjit X. Singh +8 more
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The Non-Equilibrium Thermodynamics of Natural Selection: From Molecules to the Biosphere
Entropy, 2023 Evolutionary theory suggests that the origin, persistence, and evolution of biology is driven by the “natural selection” of characteristics improving the differential reproductive success of the organism in the given environment.
Karo Michaelian
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Adenine Nucleotide and Nicotinamide Adenine Dinucleotide Measurements in Plants [PDF]
Current Protocols in Plant Biology, 2020 AbstractAs the principal co‐factors of many metabolic pathways, the measurement of both adenine nucleotides and nicotinamide adenine dinucleotide provides important information about cellular energy metabolism. However, given their rapid and reversible conversion as well as their relatively low concentration ranges, it is difficult to measure these ...
Zhang, Youjun +4 more
openaire +4 more sources