Results 11 to 20 of about 252,905 (308)

Quadracyclic Adenine: A Non‐Perturbing Fluorescent Adenine Analogue [PDF]

Chemistry – A European Journal, 2012
AbstractFluorescent‐base analogues (FBAs) comprise a group of increasingly important molecules for the investigation of nucleic acid structure and dynamics as well as of interactions between nucleic acids and other molecules. Here, we report on the synthesis, detailed spectroscopic characterisation and base‐pairing properties of a new environment ...
Dierckx, Anke, Miannay, Francois-Alexandre, Ben Gaied, Nouha, Preus, Søren, Björck, Markus, Brown, Tom, Wilhelmsson, L. Marcus   +6 more
openaire   +4 more sources

Nanoporous Cu(II)-Adenine-Based Metal–Organic Frameworks for Selective Adsorption of C₂H₂ from C₂H₄ and CO₂ [PDF]

, 2023
In some important chemical processes, selective removal of C2H2 from other gases is necessary. The method of selecting porous materials for separation is energy-efficient and economical in comparison with some traditional methods, such as solvent ...
Lin-Hua Xie (2322403), Guang-Yun Wang (17427944), Qiao Ye (6325778), Yuan Luo (10799), Lu Wang (45927), Jie Lv (235936)   +5 more
core   +3 more sources

Preorganized Internal Electric Field Promotes a Double-displacement Mechanism for the Adenine Excision Reaction by Adenine DNA Glycosylase [PDF]

, 2023
Adenine DNA glycosylase (MutY) is a monofunctional glycosylase, removing adenines (A) misinserted opposite 8-oxo-7,8-dihydroguanine (OG), a common product of oxidative damage to DNA.
Wenwen, Diao, Zhanfeng, Wang, Fangfu , Ye, James D., Farrell, Binju, Wang   +4 more
core   +1 more source

Tautomerisation Mechanisms in the Adenine-Thymine Nucleobase Pair During DNA Strand Separation [PDF]

, 2022
The adenine-thymine tautomer (A*-T*) has previously been discounted as a spontaneous mutagenesis mechanism due to the energetic instability of the tautomeric configuration.
Max, Winokan, Jim, Al-Khalili, Louie, Slocombe, Marco, Sacchi, Benjamin, King, Paul, Stevenson   +5 more
core   +1 more source

CoCl₂-Mimicked Endothelial Cell Hypoxia Induces Nucleotide Depletion and Functional Impairment That Is Reversed by Nucleotide Precursors

Biomedicines, 2022
Chronic hypoxia drives vascular dysfunction by various mechanisms, including changes in mitochondrial respiration. Although endothelial cells (ECs) rely predominantly on glycolysis, hypoxia is known to alter oxidative phosphorylation, promote oxidative ...
Barbara Kutryb-Zajac, Ada Kawecka, Alicja Braczko, Marika Franczak, Ewa M. Slominska, Roberto Giovannoni, Ryszard T. Smolenski   +6 more
doaj   +1 more source

Synthesis of purines and adenines containing the hexafluoroisopropyl group

Beilstein Journal of Organic Chemistry, 2020
Several new derivatives of adenine, purine, and theophylline containing the (CF3)2CH group connected to a nitrogen atom of the imidazole ring were prepared by the reaction of 2,2,4,4-tetrakis(trifluoromethyl)-1,3-dithietane (1) with the corresponding ...
Viacheslav Petrov, Rebecca J. Dooley, Alexander A. Marchione, Elizabeth L. Diaz, Brittany S. Clem, William Marshall   +5 more
doaj   +1 more source

Uraemic Cardiomyopathy in Different Mouse Models

Frontiers in Medicine, 2021
Uraemic cardiomyopathy (UCM) is one of the most common complications in chronic kidney disease (CKD). Our aim was to compare characteristics of various UCM mouse models. Mice were assigned to the following groups: the pole ligation group, 5/6 nephrectomy
Cheng Chen, Cheng Chen, Caidie Xie, Hanzhang Wu, Lin Wu, Jingfeng Zhu, Huijuan Mao, Changying Xing   +7 more
doaj   +1 more source

Metal-ion binding and metal-ion induced folding of the adenine-sensing riboswitch aptamer domain [PDF]

, 2010
Divalent cations are important in the folding and stabilization of complex RNA structures. The adenine-sensing riboswitch controls the expression of mRNAs for proteins involved in purine metabolism by directly sensing intracellular adenine levels ...
Wöhnert, Jens, Schwalbe, Harald (Prof. Dr.), Noeske, Jonas   +2 more
core   +1 more source

Comparative analysis of inflammatory and oxidative stress indicators in rat models of CKD induced by adenine versus folic acid; an experimental study [PDF]

Journal of Nephropathology
Introduction: Chronic kidney disease (CKD) is a progressive condition characterized by inflammation, oxidative stress, and significant renal dysfunction. Animal models are indispensable for studying CKD pathophysiology and testing therapeutic strategies.
Asaad Abass Fadhel Khalif, Bahir Abdul Razzaq Mshimesh, Deyaa Abdul Hussein Abood, Safaa Abdulsattar Oudah Al-Qaysi   +3 more
doaj   +1 more source

Adenine deaminase and adenine utilization in Saccharomyces cerevisiae [PDF]

Journal of Bacteriology, 1992
Compared with other purine salvage and nitrogen catabolism enzymatic activities, adenine deaminase (adenine aminohydrolase [AAH]; EC 3.5.4.2) activity in Saccharomyces cerevisiae is uniquely regulated. AAH specific activity is not induced by adenine and is reduced sevenfold when cells are cultivated in medium containing proline in place of ammonium as ...
openaire   +2 more sources