Results 41 to 50 of about 47,793 (252)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Adenine-induced chronic kidney disease in rats

, 2017
Many animal models have been developed to study the causes and treatments of chronic kidney disease (CKD) in humans, an insidious disease resulting from kidney injury and characterised by persistent functional decline for more than 3 months, with or ...
Vishal Diwan, Lindsay Brown, Gobe, Glenda C., Diwan, Vishal, Brown, Lindsay, Gobe, Glenda C, Glenda C Gobe   +6 more
core   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Three Generations of Huntington’s Disease in a Family-Diagnosed after Juvenile Presentation in an Adolescent: A Case Report

Indian Pediatrics Case Reports
Background: Huntington’s disease (HD) is a neurodegenerative disorder characterized by dominant inheritance, choreoathetosis, cognitive decline, and psychiatric disturbances.
Keerthana Muralidhar, Muganagowda Patil
doaj   +1 more source

Infrared Spectral Signatures of Nucleobases in Interstellar Ices I: Purines

Life, 2023
The purine nucleobases adenine and guanine are complex organic molecules that are essential for life. Despite their ubiquitous presence on Earth, purines have yet to be detected in observations of astronomical environments.
Caroline Antunes Rosa, Alexandre Bergantini, Péter Herczku, Duncan V. Mifsud, Gergő Lakatos, Sándor T. S. Kovács, Béla Sulik, Zoltán Juhász, Sergio Ioppolo, Heidy M. Quitián-Lara, Nigel J. Mason, Claudia Lage   +11 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

RETRACTED: Adenine Combined with Cisplatin Promotes Anticancer Activity against Hepatocellular Cancer Cells through AMPK-Mediated p53/p21 and p38 MAPK Cascades

Pharmaceuticals, 2022
Cisplatin has been widely used in cancer treatments. Recent evidence indicates that adenine has potential anticancer activities against various types of cancers. However, the effects of the combination of adenine and cisplatin on hepatocellular carcinoma
Jhen-Yu Huang, You-Cian Lin, Han-Min Chen, Jiun-Tsai Lin, Shao-Hsuan Kao   +4 more
doaj   +1 more source

The Suppressor of AAC2 Lethality SAL1 Modulates Sensitivity of Heterologously Expressed Artemia ADP/ATP Carrier to Bongkrekate in Yeast [PDF]

, 2013
The ADP/ATP carrier protein (AAC) expressed in Artemia franciscana is refractory to bongkrekate. We generated two strains of Saccharomyces cerevisiae where AAC1 and AAC3 were inactivated and the AAC2 isoform was replaced with Artemia AAC containing a ...
Adam-Vizi, Vera, Monika Wysocka-Kapcinska (368157), Christos Chinopoulos (317665), Roza Kucharczyk (141980), Christos Chinopoulos, Cynthia L David, Chinopoulos Christos, Hunt AM, Vekey, Karoly, Beata Torocsik (317661), Hunt Andrea M., Roza Kucharczyk, Karoly Vekey (5656285), Kucharczyk Roza, Wysocka-Kapcinska M, Cynthia L. David, Vera Adam-Vizi (317663), Vékey Károly, Cynthia L. David (461150), Törőcsik Beáta, Ádám Veronika, Monika Wysocka-Kapcinska, Andrea M. Hunt, Wysocka-Kapcinska, Monika, Lilla Turiak, Tsaprailis, George, David Cynthia L., Törőcsik, Beáta, Turiák, Lilla, Tsaprailis George, Andrea M. Hunt (461151), Wysocka-Kapcinska Monika, Beata Torocsik, Vera Adam-Vizi, George Tsaprailis (268492), Ádám, Veronika, Kucharczyk R, Andrea M Hunt, David CL, George Tsaprailis, Tsaprailis G, Chinopoulos, Christos, Turiák Lilla, Hunt, Andrea M., Lilla Turiak (5656282), Kucharczyk, Roza, David, Cynthia L., Karoly Vekey, Adam-Vizi Vera   +48 more
core   +2 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Surface-Enhanced Raman Spectroscopy (SERS) for Identifying Traces of Adenine in Organic-Bearing Extraterrestrial Dust Analogs Captured in the Tanpopo Aerogel after Hypervelocity Impacts

Gels
Raman spectroscopy is a non-destructive analytical technique for characterizing organic and inorganic materials with spatial resolution in the micrometer range. This makes it a method of choice for space-mission sample characterization, whether on return
Aline Percot, Farah Mahieddine, Hajime Yano, Sunao Hasegawa, Makoto Tabata, Akihiko Yamagishi, Hajime Mita, Alejandro Paredes-Arriaga, Marie-Christine Maurel, Jean-François Lambert, Donia Baklouti, Emilie-Laure Zins   +11 more
doaj   +1 more source