Results 41 to 50 of about 276,635 (308)
(1RS,2RS,6RS)-2-(6-Amino-9H-purin-9-yl)-8-azaspiro[5.6]dodec-10-en-1-ol Dihydrochloride
Molbank, 2022 The title compound (1RS,2RS,6RS)-2-(6-Amino-9H-purin-9-yl)-8-azaspiro[5.6]dodec-10-en-1-ol dihydrochloride was synthesized for the first time in two steps, the first of which was a regioselectivity of epoxide ring-opening reaction under the action of ...
Ildar R. Iusupov +3 more
doaj +1 more source
Antagonism of Morphine Analgesia by Adenine, Adenosine, and Adenine Nucleotides
Experimental Biology and Medicine, 1973 SummaryAntagonism of the antinociceptive action of morphine in mice by prior parenteral administration of cAMP has been confirmed using two additional analgesic testing procedures, the hot-plate test and the stretching test. The analgesia-antagonistic property, however, is not specific for cAMP because it also occurred after pretreatment with compounds
D R, Gourley, S K, Beckner
openaire +2 more sources
Aggregation of nucleobases and metabolites: Adenine-theobromine trimers [PDF]
, 2023 The selection of cytosine, guanine, thymine, and adenine as components of the information biopolymers was a complex process influenced by several factors. Among them, the intermolecular interactions may have played a determinant role.
Camiruaga, Ander [0000-0001-9829-0656] +17 more
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
The Dissipative Photochemical Origin of Life: UVC Abiogenesis of Adenine
Entropy, 2021 The non-equilibrium thermodynamics and the photochemical reaction mechanisms are described which may have been involved in the dissipative structuring, proliferation and complexation of the fundamental molecules of life from simpler and more common ...
Karo Michaelian
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
, 2014 Gender contributes to differences in incidence and progression of chronic kidney disease (CKD) and associated cardiovascular disease. To induce kidney damage in male and female Wistar rats (n = 12/group), a 0.25% adenine diet for 16 wk was used.
Kauter, Kate +4 more
core +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Infrared Spectral Signatures of Nucleobases in Interstellar Ices I: Purines
Life, 2023 The purine nucleobases adenine and guanine are complex organic molecules that are essential for life. Despite their ubiquitous presence on Earth, purines have yet to be detected in observations of astronomical environments.
Caroline Antunes Rosa +11 more
doaj +1 more source
Phosphonylmethoxyalkyl and phosphonylalkyl derivatives of adenine
, 1988 Analogues of the antivirals (2S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (Ia) and 9-(2-phosphonylmethoxyethyl)adenine (Ib), modified in the alkyl chain, are described.
Antonín Holý +2 more
core +1 more source