Results 61 to 70 of about 397,718 (300)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Immobilization and 3D Hot-Junction Formation of Gold Nanoparticles on Two-Dimensional Silicate Nanoplatelets as Substrates for High-Efficiency Surface-Enhanced Raman Scattering Detection

Nanomaterials, 2019
We synthesize a high-efficiency substrate for surface-enhanced Raman scattering (SERS) measurements, which is composed of gold nanoparticles (AuNPs) on two-dimensional silicate nanoplatelets acting as an inorganic stabilizer, via the in-situ reduction of
Yen-Chen Lee, Chih-Wei Chiu
doaj   +1 more source

DNA Nucleobase Synthesis at Titan Atmosphere Analog by Soft X-rays

, 2009
Titan, the largest satellite of Saturn, has an atmosphere chiefly made up of N2 and CH4 and includes traces of many simple organic compounds. This atmosphere also partly consists of haze and aerosol particles which during the last 4.5 gigayears have been
Abbate M., Abe I., Basile B., Coll P., d’Hendecourt L. B., Gerakines P. A., Gibb E. L., Glaser R., Grasset O., Griffith C. A., Gueymard C. A., Imanaka H., Imanaka H., Kerkhof O., Khare B. N., Khare B. N., Khare B. N., Kobayashi K., Kobayashi K., Kobayashi K., Kobayashi K., Lappi S. E., Lorenz R. D., Lowe C. U., McDonald G. D., McGuigan M., Miller S. L., Mitri G., Moore M. H., Neish C. D., Nuevo M., Oró J., Oró J., Oró J., Pietrogrande M. C., Pilling S., Ponnamperuma C., Pullman B., Sagan C., Tran B. N., Tran B. N., Wakamatsu H., Wang F., Yamada Y., Yamanashi H., Yuasa S.   +45 more
core   +2 more sources

Chronic Kidney Disease Increases Cerebral Microbleeds in Mouse and Man. [PDF]

, 2020
Brain microbleeds are increased in chronic kidney disease (CKD) and their presence increases risk of cognitive decline and stroke. We examined the interaction between CKD and brain microhemorrhages (the neuropathological substrate of microbleeds) in ...
Bangash, Maria, Cribbs, David H, Fisher, Mark, Floriolli, David, Lau, Wei Ling, Lertpanit, Long, Naqvi, Sameen, Nunes, Ane CF, Paganini-Hill, Annlia, Savoj, Javad, Shah, Krunal, Vasilevko, Vitaly, Vaziri, Nosratola D, Yao, Zhihui   +13 more
core  

Back-electron transfer suppresses the periodic length dependence of DNA-mediated charge transport across adenine tracts [PDF]

, 2008
DNA-mediated charge transport (CT) is exquisitely sensitive to the integrity of the bridging π-stack and is characterized by a shallow distance dependence. These properties are obscured by poor coupling between the donor/acceptor pair and the DNA bridge,
Augustyn, Katherine E., Barton, Jacqueline K., Davis, Molly L., Genereux, Joseph C., Shao, Fangwei   +4 more
core   +2 more sources

Adenine Phosphoribosyltransferase Deficiency [PDF]

Clinical Journal of the American Society of Nephrology, 2012
Summary Complete adenine phosphoribosyltransferase (APRT) deficiency is a rare inherited metabolic disorder that leads to the formation and hyperexcretion of 2,8-dihydroxyadenine (DHA) into urine. The low solubility of DHA results in precipitation of this compound and the formation of urinary crystals and stones.
Guillaume, Bollée, Jérôme, Harambat, Albert, Bensman, Bertrand, Knebelmann, Michel, Daudon, Irène, Ceballos-Picot   +5 more
openaire   +2 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Crystallographic and SAXS studies of S-adenosyl-l-homocysteine hydrolase from Bradyrhizobium elkanii

IUCrJ, 2017
S-Adenosyl-l-homocysteine hydrolase (SAHase) from the symbiotic bacterium Bradyrhizobium elkanii (BeSAHase) was crystallized in four ligand complexes with (i) mixed adenosine (Ado) and cordycepin (Cord; 3′-deoxyadenosine), (ii) adenine (Ade), (iii) Ado ...
Tomasz Manszewski, Kamil Szpotkowski, Mariusz Jaskolski   +2 more
doaj   +1 more source

Experimental and theoretical study of DNA oxidation [PDF]

, 2008
The electrochemical oxidation of DNA and bases at a glassy carbon electrode were investigated using cyclic and square-wave voltammetry analysis. The predicted oxidative potentials for DNA and bases using DFT method (B3LYP) are in agreement with the ...
Yuanzhi Song
core   +1 more source

Separation of oxidatively damaged DNA Nucleobases and Nucleosides on Packed and Monolith C18 Columns by HPLC-UV-EC [PDF]

, 2008
This study involves the incorporation of a commercially available Phenomenex Onyx C18 monolith column into the separation and detection of oxidative DNA damage.
Kelly, Michele C., Smyth, Malcolm R., White, Blánaid   +2 more
core   +1 more source