Results 71 to 80 of about 252,905 (308)
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
254 - Effect of the Adenine Moiety on the Electrochemical Behavior of Nicotinamide Adenine Dinucleotide; Possible Reduction of the Adenine [PDF]
, 1978 The presence of the adenine moiety very markedly affects the adsorption phenomena at the solution|electrode interface associated with nicotinamide adenine dinucleotide (NAD+) in aqueous media.
Schmakel, Conrad O. +2 more
core +1 more source
Crystallographic and SAXS studies of S-adenosyl-l-homocysteine hydrolase from Bradyrhizobium elkanii
IUCrJ, 2017 S-Adenosyl-l-homocysteine hydrolase (SAHase) from the symbiotic bacterium Bradyrhizobium elkanii (BeSAHase) was crystallized in four ligand complexes with (i) mixed adenosine (Ado) and cordycepin (Cord; 3′-deoxyadenosine), (ii) adenine (Ade), (iii) Ado ...
Tomasz Manszewski +2 more
doaj +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
On the evolution of protein-adenine binding [PDF]
, 2020 Proteins' interactions with ancient ligands may reveal how molecular recognition emerged and evolved. We explore how proteins recognize adenine: a planar rigid fragment found in the most common and ancient ligands.
Solan, R. +5 more
core +1 more source
Adenine-based cofactors provide alternative paths for acetic acid phosphorylation. [PDF]
, 2022 (A) Acetic acid can be directly phosphorylated by reacting with pyrophosphate. (B) With CoA present, an alternative path to phosphorylate acetic acid by consuming phosphate rather than pyrophosphate becomes possible.
Zhen Peng (539724) +2 more
core +1 more source
The impact of altered dietary adenine concentrations on the gut microbiota in Drosophila
Frontiers in MicrobiologyThe gut microbiota influences host metabolism and health, impacting diseases. Research into how diet affects gut microbiome dynamics in model organisms is crucial but underexplored. Herein, we examined how dietary adenine affects uric acid levels and the
Xianglin Yin +10 more
doaj +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
Adenine methylation in zein genes [PDF]
, 2013 This paper reports the novel finding of adenine methylation in higher plants. Comparison of restriction patterns of genomic maize DNA digested with enzymes MboI and Sau3A enabled us to detect the existence of adenine methylation in zein genes.
Pintor-Toro, José Antonio
core +1 more source