Results 71 to 80 of about 276,635 (308)

Adenine-induced chronic kidney disease in rats

, 2017
Many animal models have been developed to study the causes and treatments of chronic kidney disease (CKD) in humans, an insidious disease resulting from kidney injury and characterised by persistent functional decline for more than 3 months, with or ...
Vishal Diwan, Lindsay Brown, Gobe, Glenda C., Diwan, Vishal, Brown, Lindsay, Gobe, Glenda C, Glenda C Gobe   +6 more
core   +1 more source

An Effector TaCRVP From Tuta Absoluta Oral Secretion Impairs H2O2‐Mediated Plant Defense by Targeting Tomato SlCAT2

Advanced Science, EarlyView.
The Tuta absoluta salivary effector TaCRVP subverts tomato immunity by hijacking host catalase SlCAT2. Through a sophisticated dual mechanism, TaCRVP simultaneously promotes SlCAT2 tetramerization for activation and blocks its SlAdBiL‐mediated degradation for stabilization.
Jianquan Yan, Youdan Zhang, Zhujun Wang, Huatao Tang, Huiping Liu, Zi Chen, Shuai Liu, Jiayi Shi, Lu Peng, Youming Hou   +9 more
wiley   +1 more source

The impact of altered dietary adenine concentrations on the gut microbiota in Drosophila

Frontiers in Microbiology
The gut microbiota influences host metabolism and health, impacting diseases. Research into how diet affects gut microbiome dynamics in model organisms is crucial but underexplored. Herein, we examined how dietary adenine affects uric acid levels and the
Xianglin Yin, Xianglin Yin, Qing Tong, Jingtao Wang, Jinfeng Wei, Zhenbo Qin, Yujie Wu, Ruidi Zhang, Baosheng Guan, Hongbin Qiu, Hongbin Qiu   +10 more
doaj   +1 more source

Crystallographic and SAXS studies of S-adenosyl-l-homocysteine hydrolase from Bradyrhizobium elkanii

IUCrJ, 2017
S-Adenosyl-l-homocysteine hydrolase (SAHase) from the symbiotic bacterium Bradyrhizobium elkanii (BeSAHase) was crystallized in four ligand complexes with (i) mixed adenosine (Ado) and cordycepin (Cord; 3′-deoxyadenosine), (ii) adenine (Ade), (iii) Ado ...
Tomasz Manszewski, Kamil Szpotkowski, Mariusz Jaskolski   +2 more
doaj   +1 more source

Glibenclamide improves kidney and heart structure and function in the adenine-diet model of chronic kidney disease

, 2014
The development of chronic kidney disease (CKD) and associated cardiovascular disease involves free radical damage and inflammation. Addition of adenine to the diet induces inflammation followed by CKD and cardiovascular disease.
Diwan, Vishal, Brown, Lindsay, Gobe, Glenda   +2 more
core   +1 more source

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

HOTSPOT STABILIZATION OF GOLD NANOPARTICLES FOR APPLICATION OF QUANTITATIVE SERS IN BIOANALYTICAL SYSTEMS [PDF]

Química Nova
A complete procedure including synthesizing gold nanoparticles and further hotspots stabilization is presented. Colloidal gold synthesis followed a citrate reducing reaction, then, an ideal condition for SERS enhancement with quantitative purposes was ...
Mónica B. Mamián-López, Marcia L. A. Temperini   +1 more
doaj   +2 more sources

Novel Cd (II) Coordination Polymers Afforded with EDTA or Trans-1,2-Cdta Chelators and Imidazole, Adenine, or 9-(2-Hydroxyethyl) Adenine Coligands

Crystals, 2020
Three mixed-ligands of Cd(II) coordination polymers were unintentionally obtained: {[Cd(µ3-EDTA)(Him)·Cd(Him)(H2O)2]·H2O}n (1), {[Cd(µ4-CDTA)(Hade)·Cd(Hade)2]}n (2), and {[Cd(µ3-EDTA)(H2O)·Cd(H9heade)(H2O)]·2H2O}n (3), having imidazole (Him), adenine ...
Jeannette Carolina Belmont-Sánchez, María Eugenia García-Rubiño, Antonio Frontera, Antonio Matilla-Hernández, Alfonso Castiñeiras, Juan Niclós-Gutiérrez   +5 more
doaj   +1 more source

Second-Generation Fluorescent Quadracyclic Adenine Analogues: Environment-Responsive Probes with Enhanced Brightness [PDF]

, 2015
This thesis focuses on the design, synthesis and utilization of fluorescent nucleobase analogues (FBAs). FBAs are an important class of compounds, used in the research of nucleic acids. The class of canonical FBAs, i.e.
Bood, Mattias, Sandberg Wranne, Moa,, Dumat, Blaise, Gr\uf6tli, Morten, Grötli, Morten,, Lawson, Chris, Wellner, E.,, Dumat, Blaise,, Streling, J., Grøtli, Morten,, Lawson, Chris,, Lawson, Christopher P.,, Wellner, E., Streling, J.,, Larsen, Anders Foller,, Gradén, H.,, Preus, S., Bood, Mattias,, Sandberg Wranne, Moa, Wilhelmsson, Marcus, Preus, S.,, Grad\ue9n, H., F\ufcchtbauer, Anders Foller, Dumat, B., Gradén, H., Füchtbauer, Anders Foller,, Wilhelmsson, Marcus,   +26 more
core   +1 more source