Results 51 to 60 of about 252,905 (308)

Infrared Spectral Signatures of Nucleobases in Interstellar Ices I: Purines

Life, 2023
The purine nucleobases adenine and guanine are complex organic molecules that are essential for life. Despite their ubiquitous presence on Earth, purines have yet to be detected in observations of astronomical environments.
Caroline Antunes Rosa, Alexandre Bergantini, Péter Herczku, Duncan V. Mifsud, Gergő Lakatos, Sándor T. S. Kovács, Béla Sulik, Zoltán Juhász, Sergio Ioppolo, Heidy M. Quitián-Lara, Nigel J. Mason, Claudia Lage   +11 more
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Bacterial Analysis Using an Electrochemical DNA Biosensor with Poly-Adenine-Mediated DNA Self-Assembly [PDF]

, 2018
The spatial arrangement of DNA probes on the electrode surface is of critical significance for the performance of electrochemical biosensors. However, rational control of the probe surface remains challenging.
Qin Xu (93193), Lanying Li (1839166), Lele Wang (542468), Zhilei Ge (1844305), Gang Liu (81776), Ali Aldalbahi (1556473), Jiang Li (272926), Yan Li (23143), Min Ding (545532), Lihua Wang (14548), Na Lu (325317), Juan Yan (746051), Yanli Wen (1731706), Li Xu (108702), Wen Liang (462807)   +14 more
core   +1 more source

RETRACTED: Adenine Combined with Cisplatin Promotes Anticancer Activity against Hepatocellular Cancer Cells through AMPK-Mediated p53/p21 and p38 MAPK Cascades

Pharmaceuticals, 2022
Cisplatin has been widely used in cancer treatments. Recent evidence indicates that adenine has potential anticancer activities against various types of cancers. However, the effects of the combination of adenine and cisplatin on hepatocellular carcinoma
Jhen-Yu Huang, You-Cian Lin, Han-Min Chen, Jiun-Tsai Lin, Shao-Hsuan Kao   +4 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Surface-Enhanced Raman Spectroscopy (SERS) for Identifying Traces of Adenine in Organic-Bearing Extraterrestrial Dust Analogs Captured in the Tanpopo Aerogel after Hypervelocity Impacts

Gels
Raman spectroscopy is a non-destructive analytical technique for characterizing organic and inorganic materials with spatial resolution in the micrometer range. This makes it a method of choice for space-mission sample characterization, whether on return
Aline Percot, Farah Mahieddine, Hajime Yano, Sunao Hasegawa, Makoto Tabata, Akihiko Yamagishi, Hajime Mita, Alejandro Paredes-Arriaga, Marie-Christine Maurel, Jean-François Lambert, Donia Baklouti, Emilie-Laure Zins   +11 more
doaj   +1 more source

Mutual Relations between Substituent Effect, Hydrogen Bonding, and Aromaticity in Adenine-Uracil and Adenine-Adenine Base Pairs

Molecules, 2020
The electronic structure of substituted molecules is governed, to a significant extent, by the substituent effect (SE). In this paper, SEs in selected nucleic acid base pairs (Watson-Crick, Hoogsteen, adenine-adenine) are analyzed, with special emphasis ...
Paweł A. Wieczorkiewicz, Halina Szatylowicz, Tadeusz M. Krygowski   +2 more
doaj   +1 more source

Mechanism study on the effect of adenine on the viability of Lactiplantibacillus plantarum LIP-1 powder via freeze-drying

Food Science of Animal Products, 2023
Adenine acts as a growth promoter to promote the growth of the lactic acid bacteria (LAB), but the effect on the viability of freeze-dried strains has rarely been studied.
Qiaoling Zhang, Rongze Ma, Jinqi Cao, Ruoru Zhuang, Shuyi Jiao, Xingkun Guo, Jingjing E, Junguo Wang   +7 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Adenine-Based Zn(II)/Cd(II) Metal–Organic Frameworks as Efficient Heterogeneous Catalysts for Facile CO₂ Fixation into Cyclic Carbonates: A DFT-Supported Study of the Reaction Mechanism [PDF]

, 2019
We synthesized two new adenine-based Zn­(II)/Cd­(II) metal–organic frameworks (MOFs), namely, [Zn2(H2O)­(stdb)2(5H-Ade)­(9H-Ade)2]n (PNU-21) and [Cd2(Hstdb)­(stdb)­(8H-Ade)­(Ade)]n (PNU-22), containing auxiliary dicarboxylate ligand (stdb = 4,4 ...
Youngson Choe, Youngson Choe (1509295), Srimai Vuppala, Yunjang Gu, Eringathodi Suresh (595864), Dae-Won Park, Yunjang Gu (7296563), Yadagiri Rachuri, Srimai Vuppala (7296560), Eringathodi Suresh, Yadagiri Rachuri (1784758), Jintu Francis Kurisingal, Dae-Won Park (3367139), Joonkyung Jang, Ramesh Kumar Chitumalla, Jintu Francis Kurisingal (7296557), Joonkyung Jang (1609504), Ramesh Kumar Chitumalla (1559332)   +17 more
core   +1 more source