Results 91 to 100 of about 276,635 (308)

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Fox grape cv. Bordô (Vitis labrusca L.) and grapevine cv. Chardonnay (Vitis vinifera L.) cultivated in vitro under different carbohydrates, amino acids and 6-Benzylaminopurine levels

Brazilian Archives of Biology and Technology, 2013
The aim of this work was to study the influence of sucrose and glucose, amino acids and BAP (6-Benzylaminopurine) levels on in vitro shoot regeneration of fox grape cv. Bordô and grapevine cv. Chardonnay.
Dayse Cristina de Carvalho, André Luís Lopes da Silva, Mariane Ruzza Schuck, Marivel Purcino, Guilherme Nakao Tanno, Luiz Antonio Biasi   +5 more
doaj  

Adenine-induced animal model of chronic kidney disease: current applications and future perspectives

Renal Failure
Chronic kidney disease (CKD) with high morbidity and mortality all over the world is characterized by decreased kidney function, a condition which can result from numerous risk factors, including diabetes, hypertension and obesity.
Qiao Yang, Songya Su, Nan Luo, Gang Cao
doaj   +1 more source

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

Advanced Science, EarlyView.
An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu   +10 more
wiley   +1 more source

Radiological Evaluation of Huntington’s Disease: A Case Report [PDF]

Journal of Clinical and Diagnostic Research
Huntington’s Disease (HD) is a rare neurodegenerative condition inherited in an autosomal dominant pattern, where Gamma Amino Butyric Acid-ergic (GABAergic) neurons in the basal ganglia progressively deteriorate.
Soumyabrata Debnath, R Harshith
doaj   +1 more source

Structural complexes of human adenine phosphoribosyltransferase reveal novel features of the APRT catalytic mechanism

, 2008
Adenine phosphoribosyltransferase (APRT) is an important enzyme component of the purine recycling pathway. Parasitic protozoa of the order Kinetoplastida are unable to synthesize purines de novo and use the salvage pathway for the synthesis of purine ...
SILVA, Marcio, LULEK, Jorge, SILVA, Carlos H. T. P., THIEMANN, Otavio H.   +3 more
core  

254 - Effect of the Adenine Moiety on the Electrochemical Behavior of Nicotinamide Adenine Dinucleotide; Possible Reduction of the Adenine

, 1978
The presence of the adenine moiety very markedly affects the adsorption phenomena at the solution|electrode interface associated with nicotinamide adenine dinucleotide (NAD+) in aqueous media.
Schmakel, Conrad O., Elving, Philip Juliber, Jensen, Mark A.   +2 more
core   +1 more source

Spectroscopic Evaluation of Novel Adenine/Thymine-Conjugated Naphthalenediimides: Preference of Adenine-Adenine over Thymine-Thymine Intermolecular Hydrogen Bonding in Adenine- and Thymine-Functionalized Naphthalenediimides [PDF]

, 2019
The synthesis and spectroscopic characterization of novel nucleobase (adenine/thymine)-conjugated naphthalenediimides (NDIs), namely, NDI-AA, NDI-TT, and NDI-AT have been successfully achieved. NDI-AA, NDI-TT and NDI-AT have similar absorption in the 300–
Neouchy, Zeina, Elaridi, Jomana, Bouhadir, Kamal Hani, Al Homsi, Nadine, Koubeissi, Ali, Patra, Digambara, Jaafar, Sara   +6 more
core   +1 more source

An ATP7A‐Mediated Endogenous Regulation Bio‐Clay Enzyme Enables Self‐Amplified Copper Accumulation for Immunogenic Pyrop

Advanced Science, EarlyView.
A self‐amplifying bio‐clay nanozyme (Bio‐Clayzyme) disrupts tumor metabolic homeostasis through endogenous copper transporter ATPase (ATP7A) downregulation, enhancing cascade catalysis and triggering immunogenic pyroptosis for effective tumor immunotherapy.
Weimin Xie, Yan Li, Guangyao Li, Ying Chen, Huaming Yang   +4 more
wiley   +1 more source

Novel Adenine–Hydrazone Hybrids Against Human Lung Adenocarcinoma (A549): Design, Synthesis, Cellular Mechanistic Investigation and Molecular Docking Studies

Pharmaceuticals
Background/Objectives: Adenine derivatives are promising anticancer scaffolds, but their cellular mechanisms remain unclear. This study aimed to synthesize adenine–hydrazone hybrids and evaluate their cytotoxic effects in human lung adenocarcinoma (A549)
Emre Menteşe, Nedime Çalışkan, Didem Aksu, Mustafa Emirik, Adem Güner, Fatih Yılmaz   +5 more
doaj   +1 more source