Substitutional Sodium Doping on Tungsten Ditelluride: A First-principles Study [PDF]
Bibechana, 2022 Methylation at O6 atom of guanine is a type of DNA damage which can cause a cancer. This damage at O6 atom of guanine in a DNA can be transferred to SG atom of cysteine in O6-alkylguanine-DNA alkyltransferase (AGT).
Bibek Subedi, Narayan Adhikari
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Flipping Back of Extrahelical Guanine after Methyl Repair [PDF]
Bibechana, 2022 Methylation at O6 atom of guanine is a type of DNA damage which can cause a cancer. This damage at O6 atom of guanine in a DNA can be transferred to SG atom of cysteine in O6-alkylguanine-DNA alkyltransferase (AGT).
Rajendra Prasad Koirala +1 more
doaj +6 more sources
Computational investigations on target-site searching and recognition mechanisms by thymine DNA glycosylase during DNA repair process [PDF]
Acta Biochimica et Biophysica Sinica, 2022 DNA glycosylase, as one member of DNA repair machineries, plays an essential role in correcting mismatched/damaged DNA nucleotides by cleaving the N-glycosidic bond between the sugar and target nucleobase through the base excision repair (BER) pathways ...
Wang Lingyan +3 more
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Genetically encoded formaldehyde sensors inspired by a protein intra-helical crosslinking reaction [PDF]
Nature Communications, 2021 In order to understand the role of formaldehyde in living systems, real-time monitoring is required. Here the authors report a genetically encoded, reaction-based formaldehyde sensor (FAsor) that enables visualisation of formaldehyde in mammalian cells ...
Rongfeng Zhu +7 more
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The trajectory of intrahelical lesion recognition and extrusion by the human 8-oxoguanine DNA glycosylase [PDF]
Nature Communications, 2020 DNA glycosylases are lesion-specific enzymes that recognize specific nucleobase damages and catalyze their excision through cleavage of the glycosidic bond.
Uddhav K. Shigdel +6 more
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Structures of HCoV-OC43 HR1 Domain in Complex with Cognate HR2 or Analogue EK1 Peptide [PDF]
VirusesHuman coronavirus OC43 (HCoV-OC43) is usually associated with common colds, but also related to severe disease in the frail. Its envelope glycoproteins spike (S) is responsible for host-cell attachment and membrane fusion.
Xiuxiu He +3 more
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The Impact of the Secondary Binding Pocket on the Pharmacology of Class A GPCRs
Frontiers in Pharmacology, 2022 G-protein coupled receptors (GPCRs) are considered important therapeutic targets due to their pathophysiological significance and pharmacological relevance. Class A receptors represent the largest group of GPCRs that gives the highest number of validated
Attila Egyed +2 more
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Journal of Innate Immunity, 2022 The primary cause of morbidity and mortality from infection with respiratory syncytial virus (RSV) is the excessive innate immune response(s) (IIR) in which reactive oxygen species (ROS) play key role(s).
Xu Zheng +12 more
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Re-introduction of transmembrane serine residues reduce the minimum pore diameter of channelrhodopsin-2. [PDF]
PLoS ONE, 2012 Channelrhodopsin-2 (ChR2) is a microbial-type rhodopsin found in the green algae Chlamydomonas reinhardtii. Under physiological conditions, ChR2 is an inwardly rectifying cation channel that permeates a wide range of mono- and divalent cations.
Ryan Richards, Robert E Dempski
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Viruses, 2020 Peptides derived from the C-terminal heptad repeat (CHR) region of HIV-1 gp41 is potent viral membrane fusion inhibitors, such as the first clinically approved peptide drug T20 and a group of newly-designed peptides.
Danwei Yu +7 more
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