Results 1 to 10 of about 142,855 (165)
RETRACTED: DNA damage, homology-directed repair, and DNA methylation.
PLoS Genetics, 2007 To explore the link between DNA damage and gene silencing, we induced a DNA double-strand break in the genome of Hela or mouse embryonic stem (ES) cells using I-SceI restriction endonuclease. The I-SceI site lies within one copy of two inactivated tandem
Concetta Cuozzo +13 more
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Correction: DNA Damage, Homology-Directed Repair, and DNA Methylation.
PLoS Genetics, 2017 [This corrects the article DOI: 10.1371/journal.pgen.0030110.].
Concetta Cuozzo +13 more
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Frontiers in Molecular Biosciences, 2022 Protein methylation plays important roles in DNA damage response. To date, proteome-wide profiling of protein methylation upon DNA damage has been not reported yet.
Xinzhu Wang +9 more
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Clinical Epigenetics, 2023 Background Detecting organ and tissue damage is essential for early diagnosis, treatment decisions, and monitoring disease progression. Methylation-based assays offer a promising approach, as DNA methylation patterns can change in response to tissue ...
Lijing Zhang, Jinming Li
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Histone methylation and the DNA damage response [PDF]
Mutation Research/Reviews in Mutation Research, 2019 Preserving genome function and stability are paramount for ensuring cellular homeostasis, an imbalance in which can promote diseases including cancer. In the presence of DNA lesions, cells activate pathways referred to as the DNA damage response (DDR). As nuclear DNA is bound by histone proteins and organized into chromatin in eukaryotes, DDR pathways ...
Fade Gong, Kyle M. Miller
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Frontiers in Cell and Developmental Biology, 2022 Alu (B1 in rodents) hypomethylation, commonly found in diabetes mellitus patients, increases DNA damage and, consequently, delays the healing process.
Sakawdaurn Yasom +9 more
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Hypermethylation of genes detected in urine from Ghanaian adults with bladder pathology associated with Schistosoma haematobium infection. [PDF]
PLoS ONE, 2013 Schistosoma haematobium is associated with chronic bladder damage and may subsequently induce bladder cancer in humans, thus posing a serious threat where the parasite is endemic.
Xiaoli Zhong +8 more
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Cells, 2020 DNA damage and base excision repair (BER) are actively involved in the modulation of DNA methylation and demethylation. However, the underlying molecular mechanisms remain unclear.
Zhongliang Jiang +13 more
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DNA Damage Repair and DNA Methylation in the Kidney [PDF]
American Journal of Nephrology, 2019 The DNA repair system is essential for the maintenance of genome integrity and is mainly investigated in the areas of aging and cancer. The DNA repair system is strikingly cell-type specific, depending on the expression of DNA repair factors; therefore, different DNA repair systems may exist in each type of kidney cell.
Kaori, Hayashi +2 more
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Methylation of the Suppressor Gene p16INK4a: Mechanism and Consequences
Biomolecules, 2020 Tumor suppressor genes in the CDKN2A/B locus (p15INK4b, p16INK4a, and p14ARF) function as biological barriers to transformation and are the most frequently silenced or deleted genes in human cancers.
Alfonso Tramontano +5 more
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