Results 1 to 10 of about 2,934,821 (333)

Unlocking the secrets: the power of methylation-based cfDNA detection of tissue damage in organ systems

Clinical Epigenetics, 2023
Background Detecting organ and tissue damage is essential for early diagnosis, treatment decisions, and monitoring disease progression. Methylation-based assays offer a promising approach, as DNA methylation patterns can change in response to tissue ...
Lijing Zhang, Jinming Li
doaj   +3 more sources

DNA methylation changes following DNA damage in prostate cancer cells [PDF]

Epigenetics, 2019
Many cancer therapies operate by inducing double-strand breaks (DSBs) in cancer cells, however treatment-resistant cells rapidly initiate mechanisms to repair damage enabling survival.
Laura P. Sutton, Sarah A. Jeffreys, Jessica L. Phillips, Phillippa C. Taberlay, Adele F. Holloway, Mark Ambrose, Ji-Hoon E. Joo, Arabella Young, Rachael Berry, Marketa Skala, Kate H. Brettingham-Moore   +10 more
doaj   +6 more sources

PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage [PDF]

Cancer Discovery, 2019
The function of PTEN in the cytoplasm largely depends on its lipid-phosphatase activity by antagonizing the PI3K-Akt oncogenic pathway. However, molecular mechanism(s) underlying the role of PTEN in the nucleus remain largely elusive.
Jinfang Zhang, Yu-Ru Lee, Fabin Dang, Wenjian Gan, Archita V. Menon, Jesse Katon, Chih-Hung Hsu, J. Asara, Priyanka Tibarewal, N. Leslie, Yang Shi, P. Pandolfi, Wenyi Wei   +12 more
semanticscholar   +4 more sources

Alu siRNA to Increase Alu Element Methylation and Prevent DNA Damage

Epigenomics, 2018
Global DNA hypomethylation promoting genomic instability leads to cancer and deterioration of human health with age. AIM To invent a biotechnology that can reprogram this process.
Maturada Patchsung, Monnat Pongpanich, Apiwat Mutirangura   +2 more
exaly   +3 more sources

MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML. [PDF]

Blood, 2018
The tendency of 5-methylcytosine (5mC) to undergo spontaneous deamination has had a major role in shaping the human genome, and this methylation damage remains the primary source of somatic mutations that accumulate with age.
Sanders MA, Chew E, Flensburg C, Zeilemaker A, Miller SE, Al Hinai AS, Bajel A, Luiken B, Rijken M, Mclennan T, Hoogenboezem RM, Kavelaars FG, Fröhling S, Blewitt ME, Bindels EM, Alexander WS, Löwenberg B, Roberts AW, Valk PJM, Majewski IJ.   +19 more
europepmc   +2 more sources

Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase β and a de novo DNA Methyltransferase

Cells, 2020
DNA damage and base excision repair (BER) are actively involved in the modulation of DNA methylation and demethylation. However, the underlying molecular mechanisms remain unclear.
Zhongliang Jiang, Yanhao Lai, Jill M. Beaver, Pawlos S. Tsegay, Ming-Lang Zhao, Julie K. Horton, Marco Zamora, Hayley L. Rein, Frank Miralles, Mohammad Shaver, Joshua D. Hutcheson, Irina Agoulnik, Samuel H. Wilson, Yuan Liu   +13 more
doaj   +2 more sources

DNMT1-mediated PPARα methylation aggravates damage of retinal tissues in diabetic retinopathy mice

Biological Research, 2021
Background Peroxisome proliferator-activated receptor alpha (PPARα) is associated with diabetic retinopathy (DR), and the underlying mechanism is still unclear. Aim of this work was to investigate the mechanism of PPARα in DR.
Ying Zhu, Xinru Wang, Xiaoyun Zhou, Lexi Ding, Dan Liu, Huizhuo Xu   +5 more
doaj   +2 more sources

Meta-analyses identify DNA methylation associated with kidney function and damage [PDF]

Nature Communications, 2021
Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic kidney disease.
P. Schlosser, A. Tin, P. Matías-García, C. Thio, R. Joehanes, Hongbo Liu, A. Weihs, Zhi Yu, Anselm Hoppmann, Franziska Grundner-Culemann, J. Min, A. Adeyemo, Charles Agyemang, J. Ärnlöv, N. Aziz, A. Baccarelli, M. Bochud, H. Brenner, M. Breteler, C. Carmeli, L. Chaker, J. Chambers, S. Cole, J. Coresh, T. Corre, A. Correa, S. Cox, N. de Klein, G. Delgado, A. Domingo-Relloso, K. Eckardt, A. Ekici, K. Endlich, K. Evans, J. Floyd, M. Fornage, L. Franke, Eliza Fraszczyk, Xu Gao, Xīn Gào, M. Ghanbari, Sahar Ghasemi, C. Gieger, P. Greenland, Megan L. Grove, S. Harris, G. Hemani, P. Henneman, C. Herder, S. Horvath, Lifang Hou, M. Hurme, Shih-Jen Hwang, M. Jarvelin, S. Kardia, S. Kasela, M. Kleber, W. Koenig, J. Kooner, H. Kramer, F. Kronenberg, Brigitte Kühnel, T. Lehtimäki, L. Lind, Dan Liu, Yongmei Liu, D. Lloyd‐Jones, K. Lohman, S. Lorkowski, A. Lu, R. Marioni, W. März, D. McCartney, K. Meeks, L. Milani, Pashupati P. Mishra, M. Nauck, A. Navas-Acien, C. Nowak, A. Peters, H. Prokisch, B. Psaty, O. Raitakari, S. Ratliff, A. Reiner, S. Rosas, B. Schöttker, J. Schwartz, S. Sedaghat, Jennifer A. Smith, N. Sotoodehnia, H. Stocker, S. Stringhini, J. Sundström, Brenton R. Swenson, M. Tellez-Plaza, J. V. van Meurs, Jana V. van Vliet-Ostaptchouk, A. Venema, N. Verweij, R. Walker, M. Wielscher, J. Winkelmann, B. Wolffenbuttel, Wei Zhao, Yinan Zheng, M. Loh, H. Snieder, D. Levy, M. Waldenberger, K. Suszták, A. Köttgen, A. Teumer   +112 more
semanticscholar   +15 more sources

DNA Damage Repair and DNA Methylation in the Kidney [PDF]

American Journal of Nephrology, 2019
The DNA repair system is essential for the maintenance of genome integrity and is mainly investigated in the areas of aging and cancer. The DNA repair system is strikingly cell-type specific, depending on the expression of DNA repair factors; therefore ...
Kaori Hayashi, Akihito Hishikawa, H. Itoh   +2 more
semanticscholar   +3 more sources

Quantitative Analysis of the Protein Methylome Reveals PARP1 Methylation is involved in DNA Damage Response

Frontiers in Molecular Biosciences, 2022
Protein methylation plays important roles in DNA damage response. To date, proteome-wide profiling of protein methylation upon DNA damage has been not reported yet.
Xinzhu Wang, Xinzhu Wang, Xinzhu Wang, Shaojie Mi, Shaojie Mi, Mingxin Zhao, Chen Lu, Chen Lu, Chenxi Jia, Yali Chen   +9 more
doaj   +3 more sources