Results 1 to 10 of about 134,759 (258)

DNA methylation changes following DNA damage in prostate cancer cells [PDF]

Epigenetics, 2019
Many cancer therapies operate by inducing double-strand breaks (DSBs) in cancer cells, however treatment-resistant cells rapidly initiate mechanisms to repair damage enabling survival.
Laura P. Sutton, Sarah A. Jeffreys, Jessica L. Phillips, Phillippa C. Taberlay, Adele F. Holloway, Mark Ambrose, Ji-Hoon E. Joo, Arabella Young, Rachael Berry, Marketa Skala, Kate H. Brettingham-Moore   +10 more
doaj   +5 more sources

Quantitative Analysis of the Protein Methylome Reveals PARP1 Methylation is involved in DNA Damage Response

Frontiers in Molecular Biosciences, 2022
Protein methylation plays important roles in DNA damage response. To date, proteome-wide profiling of protein methylation upon DNA damage has been not reported yet.
Xinzhu Wang, Xinzhu Wang, Xinzhu Wang, Shaojie Mi, Shaojie Mi, Mingxin Zhao, Chen Lu, Chen Lu, Chenxi Jia, Yali Chen   +9 more
doaj   +1 more source

Unlocking the secrets: the power of methylation-based cfDNA detection of tissue damage in organ systems

Clinical Epigenetics, 2023
Background Detecting organ and tissue damage is essential for early diagnosis, treatment decisions, and monitoring disease progression. Methylation-based assays offer a promising approach, as DNA methylation patterns can change in response to tissue ...
Lijing Zhang, Jinming Li
doaj   +1 more source

B1 siRNA Increases de novo DNA Methylation of B1 Elements and Promotes Wound Healing in Diabetic Rats

Frontiers in Cell and Developmental Biology, 2022
Alu (B1 in rodents) hypomethylation, commonly found in diabetes mellitus patients, increases DNA damage and, consequently, delays the healing process.
Sakawdaurn Yasom, Sakawdaurn Yasom, Wilunplus Khumsri, Wilunplus Khumsri, Papatson Boonsongserm, Nakarin Kitkumthorn, Preecha Ruangvejvorachai, Apasee Sooksamran, Rujira Wanotayan, Apiwat Mutirangura   +9 more
doaj   +1 more source

Hypermethylation of genes detected in urine from Ghanaian adults with bladder pathology associated with Schistosoma haematobium infection. [PDF]

PLoS ONE, 2013
Schistosoma haematobium is associated with chronic bladder damage and may subsequently induce bladder cancer in humans, thus posing a serious threat where the parasite is endemic.
Xiaoli Zhong, Sumit Isharwal, Jean M Naples, Clive Shiff, Robert W Veltri, Chunbo Shao, Kwabena M Bosompem, David Sidransky, Mohammad O Hoque   +8 more
doaj   +1 more source

Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase β and a de novo DNA Methyltransferase

Cells, 2020
DNA damage and base excision repair (BER) are actively involved in the modulation of DNA methylation and demethylation. However, the underlying molecular mechanisms remain unclear.
Zhongliang Jiang, Yanhao Lai, Jill M. Beaver, Pawlos S. Tsegay, Ming-Lang Zhao, Julie K. Horton, Marco Zamora, Hayley L. Rein, Frank Miralles, Mohammad Shaver, Joshua D. Hutcheson, Irina Agoulnik, Samuel H. Wilson, Yuan Liu   +13 more
doaj   +1 more source

Methylation of the Suppressor Gene p16INK4a: Mechanism and Consequences

Biomolecules, 2020
Tumor suppressor genes in the CDKN2A/B locus (p15INK4b, p16INK4a, and p14ARF) function as biological barriers to transformation and are the most frequently silenced or deleted genes in human cancers.
Alfonso Tramontano, Francesca Ludovica Boffo, Giusi Russo, Mariarosaria De Rosa, Ilaria Iodice, Antonio Pezone   +5 more
doaj   +1 more source

UHRF1-induced connexin26 methylation is involved in hearing damage triggered by intermittent hypoxia in neonatal rats

Open Medicine, 2023
Ubiquitin-like with plant homeodomain and ring finger domains 1 (UHRF1) promotes the maintenance of established patterns of DNA methylation in mammalian cells.
Zhang Xingang, Zheng Jishan, Xu Huiqing, Ma Zhaoxin   +3 more
doaj   +1 more source

Multiomics analysis of adaptation to repeated DNA damage in prostate cancer cells

Epigenetics, 2023
DNA damage is frequently utilized as the basis for cancer therapies; however, resistance to DNA damage remains one of the biggest challenges for successful treatment outcomes. Critically, the molecular drivers behind resistance are poorly understood.
D. Challis, T. Lippis, R. Wilson, E. Wilkinson, J. Dickinson, A. Black, I. Azimi, A. Holloway, P. Taberlay, K. Brettingham-Moore   +9 more
doaj   +1 more source

Loss of histone H3 methylation at lysine 4 triggers apoptosis in Saccharomyces cerevisiae. [PDF]

PLoS Genetics, 2014
Monoubiquitination of histone H2B lysine 123 regulates methylation of histone H3 lysine 4 (H3K4) and 79 (H3K79) and the lack of H2B ubiquitination in Saccharomyces cerevisiae coincides with metacaspase-dependent apoptosis.
David Walter, Anja Matter, Birthe Fahrenkrog   +2 more
doaj   +1 more source