Results 41 to 50 of about 1,873,698 (292)

DNA DAMAGE BINDING PROTEIN2 Shapes the DNA Methylation Landscape [PDF]

The Plant Cell, 2016
In eukaryotes, DNA repair pathways help to maintain genome integrity and epigenomic patterns. However, the factors at the nexus of DNA repair and chromatin modification/remodeling remain poorly characterized. Here, we uncover a previously unrecognized interplay between the DNA repair factor DNA DAMAGE BINDING PROTEIN2 (DDB2) and the DNA methylation ...
Schalk, Catherine, Drevensek, Stéphanie, Kramdi, Amira, Kassam, Mohamed, Ahmed, Ikhlak, Cognat, Valerie, Graindorge, Stefanie, Bergdoll, Marc, Baumberger, Nicolas, Heintz, Dimitri, Bowler, Chris, Genschik, Pascal, Barneche, Fredy, Colot, Vincent, Molinier, Jean   +14 more
openaire   +3 more sources

The role of H3K79 methylation in transcription and the DNA damage response

Mutation Research/Reviews in Mutation Research, 2019
Chromatin plays a critical role in organizing and protecting DNA. However, chromatin acts as an impediment for transcription and DNA repair. Histone modifications, such as H3K79 methylation, promote transcription and genomic stability by enhancing transcription elongation and by serving as landing sites for proteins involved in the DNA damage response.
Mats, Ljungman, Luke, Parks, Radhika, Hulbatte, Karan, Bedi   +3 more
openaire   +3 more sources

Maternal exposure to genistein during pregnancy and oxidative DNA damage in testes of male mouse offspring

Frontiers in Nutrition, 2022
BackgroundGenistein is a dietary supplement with phyto-estrogenic properties. Therefore, high intake of genistein during pregnancy may have adverse effects on the genetic integrity of testes and germ cells of male offspring.
Roger W. L. Godschalk, Margit C. M. Janssen, Kimberly Vanhees, Sahar Barjesteh van Waalwijk van Doorn-Khosrovani, Frederik-Jan van Schooten   +4 more
doaj   +1 more source

Effects of curcumin on methyl methanesulfonate damage to mouse kidney

Biotechnic & Histochemistry, 2015
Methylmethane sulfonate (MMS) is an alkylating agent that may react with DNA and damage it. We investigated histological changes and apoptosis caused by MMS and the effects of curcumin on MMS treated mouse kidneys. Twenty-four mice were divided into four equal groups: controls injected with saline, a group injected with 40 mg/kg MMS, a group injected ...
CÜCE, Gökhan, ÇETİNKAYA, Seda, İŞİTEZ, Nilay, KÜÇÇÜKTÜRK, Serkan, SÖZEN, Mehmet Enes, DEMİREL, Hasan Hüseyin, KALKAN, Sinan, CİĞERCİ, İbrahim Hakkı   +7 more
openaire   +3 more sources

Perturbed DNA methylation by Gadd45b induces chromatin disorganization, DNA strand breaks and dopaminergic neuron death

iScience, 2021
Summary: Age is a major risk factor for neurodegenerative diseases like Parkinson’s disease, but few studies have explored the contribution of key hallmarks of aging, namely DNA methylation changes and heterochromatin destructuration, in the ...
Camille Ravel-Godreuil, Olivia Massiani-Beaudoin, Philippe Mailly, Alain Prochiantz, Rajiv L. Joshi, Julia Fuchs   +5 more
doaj   +1 more source

Grtp1 Safeguards Against Paternal Reproductive Aging and Intergenerational Behavioral Deficits by Preserving Redox Homeostasis. [PDF]

Adv Sci (Weinh)
This study identifies that Grtp1 maintains germline redox homeostasis by interacting with PRDX1/4‐TXN to antagonize paternal reproductive aging. Growth hormone restores Grtp1 expression, rectifies aberrant sperm DNA methylation, and ameliorates intergenerational anxiety and social deficits, highlighting the GH‐GRTP1 axis as a promising intervention ...
Liu Y, Liu S, Liang H, Yang J, Li Y, Yin J, Zhang X, Zhang Y, Bai D, Yan Z, Zhang Z, Jia Y, Liu K, Sheng Y, Xiang J, Xi C, Dong B, Lei X, Chen J, Wang H, Guo Y, Zhang Y, Gao S, Liu W.   +23 more
europepmc   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Histone modifications and the HtrA-like serine protease Nma111p regulate apoptosis in budding yeast [PDF]

, 2010
Histone modifications and the HtrA-like serine protease Nma111p regulate apoptosis in budding yeast David Walter, 2010, PhD Thesis, University of Basel Apoptosis is a form of programmed cell death that plays a central role in development and ...
Walter, David
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Predicting exacerbation of renal function by DNA methylation clock and DNA damage of urinary shedding cells: a pilot study

Scientific Reports
Recent reports have shown the feasibility of measuring biological age from DNA methylation levels in blood cells from specific regions identified by machine learning, collectively known as the epigenetic clock or DNA methylation clock.
Akihito Hishikawa, Erina Sugita Nishimura, Norifumi Yoshimoto, Ran Nakamichi, Eriko Yoshida Hama, Wataru Ito, Tomomi Maruki, Kengo Nagashima, Ryoko Shimizu-Hirota, Hiromasa Takaishi, Hiroshi Itoh, Kaori Hayashi   +11 more
doaj   +1 more source