Results 41 to 50 of about 2,934,821 (333)

Turnover and function of DNA methylation at transcription factor binding sites [PDF]

, 2014
Cell type identity is largely determined by regulatory networks consistent of various transcription factors. Transcription factor activity requires interaction with DNA and thus critically depends on the accessibility of binding motifs.
Feldmann, Angelika
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Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks. [PDF]

, 2012
Recruitment of 53BP1 to chromatin flanking double strand breaks (DSBs) requires γH2AX/MDC1/RNF8-dependent ubiquitination of chromatin and interaction of 53BP1 with histone H4 methylated on lysine 20 (H4K20me). Several histone methyltransferases have been
Guan, Yinghua, Rajendran, Anbazhagan, Jagesh V. Shah (116400), Anyong Xie (116396), Gunnar Schotta (116394), Anbazhagan Rajendran (116388), Yinghua Guan (116385), Anyong Xie, Yinghua Guan, Ralph Scully, Hartlerode, Andrea J., Andrea J Hartlerode, Anbazhagan Rajendran, Gunnar Schotta, Andrea J. Hartlerode, Jagesh V. Shah, Jagesh V Shah, Andrea J. Hartlerode (116383), Ralph Scully (116402), Xie, Anyong, Shah, Jagesh, Ura, Kiyoe, Kiyoe Ura (116391), Scully, Ralph, Kiyoe Ura, Schotta, Gunnar, Shah, Jagesh V.   +26 more
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Update on DNA methylation in UV radiation-related skin diseases

Pifu-xingbing zhenliaoxue zazhi, 2023
DNA methylation is a common epigenetic phenomenon that changes genetic expression without altering the DNA sequence. With deepening research on DNA methylation, more and more variable positions of methylation have been identified in a variety of diseases(
Wenting CHEN, Xinni ZHONG, Wei LI
doaj   +1 more source

DNA Repair: Bioinformatics Helps Reverse Methylation Damage [PDF]

Current Biology, 2002
Recent work has uncovered a novel DNA repair enzyme: the AlkB protein of Escherichia coli, which oxidises the methyl groups of 1-methyladenine and 3-methylcytosine to hydroxymethyl moieties; the oxidised groups are subsequently released as formaldehyde, regenerating the unmodified bases.
openaire   +4 more sources

H3 Lysine 4 Is Acetylated at Active Gene Promoters and Is Regulated by H3 Lysine 4 Methylation [PDF]

, 2011
Methylation of histone H3 lysine 4 (H3K4me) is an evolutionarily conserved modification whose role in the regulation of gene expression has been extensively studied.
Richard J. Festenstein, Bonneil, Eric, Guillemette Benoit, Festenstein Richard J., Armstrong Harry, Festenstein, Richard J., Harry Armstrong, Imhof Axel, Armstrong, Harry, Richard J Festenstein, Drogaris, Paul, Axel Imhof, Verreault Alain, Kyoko Hiragami-Hamada, Drogaris Paul, Verreault, Alain, Benoit Guillemette, Thibault Pierre, Pierre Thibault, Lin Hsiu-Hsu Sophia, Hiragami-Hamada, Kyoko, Alain Verreault, Imhof, Axel, Paul Drogaris, Hsiu-Hsu Sophia Lin, Bonneil Éric, Eric Bonneil, Festenstein, Richard J, Hiragami-Hamada Kyoko, Guillemette, Benoit, Lin, Hsiu-Hsu Sophia, Thibault, Pierre   +31 more
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CpG promoter methylation of the ALKBH3 alkylation repair gene in breast cancer

BMC Cancer, 2017
Background DNA repair of alkylation damage is defective in various cancers. This occurs through somatically acquired inactivation of the MGMT gene in various cancer types, including breast cancers. In addition to MGMT, the two E.
Olafur Andri Stefansson, Stefan Hermanowicz, Jasper van der Horst, Holmfridur Hilmarsdottir, Zuzanna Staszczak, Jon Gunnlaugur Jonasson, Laufey Tryggvadottir, Thorkell Gudjonsson, Stefan Sigurdsson   +8 more
doaj   +1 more source

Organophosphate flame retardants (OPFRs) induce genotoxicity in vivo: A survey on apoptosis, DNA methylation, DNA oxidative damage, liver metabolites, and transcriptomics.

Environment International, 2019
BACKGROUND As potential substitutes for polybrominated diphenyl ethers (PBDEs), organophosphate flame retardants (OPFRs) have been frequently detected in the environment. However, the genotoxicity induced by these OPFRs has rarely been described, and the
Rui Chen, Rui Hou, Xiangsheng Hong, Saihong Yan, Jinmiao Zha   +4 more
semanticscholar   +1 more source

Recognition of 5-hydroxymethylcytosine by the Uhrf1 SRA domain. [PDF]

, 2011
Recent discovery of 5-hydroxymethylcytosine (5hmC) in genomic DNA raises the question how this sixth base is recognized by cellular proteins. In contrast to the methyl-CpG binding domain (MBD) of MeCP2, we found that the SRA domain of Uhrf1, an essential
Frauer, C., M. Cristina Cardoso, Leonhardt, Heinrich, Frauer, Carina, Bultmann, Sebastian, Casa, V., Valentina Casa, Frauer Carina, Hoffmann, T., Cardoso, M. Cristina, Leonhardt Heinrich, Antes, I., Casa Valentina, Iris Antes, Leonhart, H., Heinrich Leonhardt, Cardoso M. Cristina, Hoffmann Thomas, Hoffmann, Thomas, Antes Iris, Thomas Hoffmann, M Cristina Cardoso, Bultmann Sebastian, Bultmann, S., Antes, Iris, Casa, Valentina, Carina Frauer, Sebastian Bultmann   +27 more
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A methylation-phosphorylation switch determines Plk1 kinase activity and function in DNA damage repair

Science Advances, 2019
Two types of small-group modifications on Plk1 control its activity and its cellular functions. Polo-like kinase 1 (Plk1) is a crucial regulator of cell cycle progression; but the mechanism of regulation of Plk1 activity is not well understood.
Weizhe Li, Hong-Yan Wang, Xiaolu Zhao, Hongguo Duan, Binghua Cheng, Yafei Liu, Mengjie Zhao, Wen-Jie Shu, Yuchao Mei, Zengqi Wen, Mingliang Tang, Lin Guo, Guohong Li, Qiang Chen, Xiaoqi Liu, Hai-Ning Du   +15 more
semanticscholar   +1 more source

Histone modifications and the HtrA-like serine protease Nma111p regulate apoptosis in budding yeast [PDF]

, 2010
Histone modifications and the HtrA-like serine protease Nma111p regulate apoptosis in budding yeast David Walter, 2010, PhD Thesis, University of Basel Apoptosis is a form of programmed cell death that plays a central role in development and ...
Walter, David
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