Results 31 to 40 of about 2,934,821 (333)

Repurposing the Damage Repair Protein Methyl Guanine Methyl Transferase as a Ligand Inducible Fusion Degron [PDF]

ACS Chemical Biology, 2022
We successfully repurpose the DNA repair protein methylguanine methyltransferase (MGMT) as an inducible degron for protein fusions. MGMT is a suicide protein that removes alkyl groups from the O6 position of guanine (O6G) and is thereafter quickly degraded by the ubiquitin proteasome pathway (UPP). Starting with MGMT pseudosubstrates (benzylguanine and
Murawska, Gosia M., Vogel, Caspar, Jan, Max, Lu, Xinyan, Schild, Matthias, Slabicki, Mikolaj, Zou, Charles, Zhanybekova, Saule, Manojkumar, Manisha, Petzold, Georg, Kaiser, Peter, Thomä, Nicolas, Ebert, Benjamin, Gillingham, Dennis   +13 more
openaire   +4 more sources

Loss of histone H3 methylation at lysine 4 triggers apoptosis in Saccharomyces cerevisiae. [PDF]

PLoS Genetics, 2014
Monoubiquitination of histone H2B lysine 123 regulates methylation of histone H3 lysine 4 (H3K4) and 79 (H3K79) and the lack of H2B ubiquitination in Saccharomyces cerevisiae coincides with metacaspase-dependent apoptosis.
David Walter, Anja Matter, Birthe Fahrenkrog   +2 more
doaj   +1 more source

In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases [PDF]

, 2012
The enzymatic control of the setting and maintenance of symmetric and non-symmetric DNA methylation patterns in a particular genome context is not well understood.
Julia Arand (155279), Meissner, A, Meilinger, D., Arand, Julia, Leonhardt, Heinrich, Jenuwein, Thomas, Wolf, Verena, Thomas Jenuwein (70681), Tommy Karius, David Spieler, Jenuwein, T., Xu, G, Tommy Karius (155285), Walter, Jörn, Wolf, V., Branco, MR, Leonhardt, H, Spieler, D, Branco, Miguel R., Meilinger, Daniela, Julia Arand, Jörn Walter, Walter, Joern, Jörn Walter (37094), Walter, J, Miguel R. Branco (42502), Verena Wolf, Karius, T, Meissner, Alexander, Arand, J, Alexander Meissner (11643), Meilinger, D, Daniela Meilinger, Heinrich Leonhardt (18589), Verena Wolf (155286), Daniela Meilinger (107843), Arand, J., Jenuwein, T, Miguel R Branco, Thomas Jenuwein, Guoliang Xu, Alexander Meissner, Walter, J., Meissner, A., Heinrich Leonhardt, Karius, Tommy, Guoliang Xu (67200), Spieler, David, Karius, T., Xu, Guoliang, David Spieler (155282), Branco, M., Xu, G., Wolf, V, Spieler, D., Leonhardt, H.   +55 more
core   +1 more source

Repair of Methylation Damage in DNA and RNA by Mammalian AlkB Homologues [PDF]

Journal of Biological Chemistry, 2005
Human and Escherichia coli derivatives of AlkB enzymes remove methyl groups from 1-methyladenine and 3-methylcytosine in nucleic acids via an oxidative mechanism that releases the methyl group as formaldehyde. In this report, we demonstrate that the mouse homologues of the alpha-ketoglutarate Fe(II) oxygen-dependent enzymes mAbh2 and Abh3 have ...
Lee, Dong-Hyun, Jin, Seung-Gi, Cai, Sheng, Chen, Yuan, Pfeifer, Gerd P, O'Connor, Timothy R   +5 more
openaire   +4 more sources

O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation [PDF]

, 2011
Background: We analyzed prospectively whether MGMT (O(6)-methylguanine-DNA methyltransferase) mRNA expression gains prognostic/predictive impact independent of MGMT promoter methylation in malignant glioma patients undergoing radiotherapy with ...
Kreth Simone, Friedrich W. Kreth, Hans A Kretzschmar, Lutz Juergen, Ludwig C. Hinske, Friedrich W Kreth, Ledderose Carola, Kretzschmar, Hans A., Kreth, Friedrich-Wilhelm, Juergen Lutz, Eigenbrod, Sabina, Kreth, Simone, Tonn, Joerg C., Thon Niklas, Thon, Niklas, Eigenbrod Sabina, Joerg C Tonn, Hinske, Ludwig C., Egensperger Rupert, Kretzschmar Hans A., Carola Ledderose, Rupert Egensperger, Kreth Friedrich W., Joerg C. Tonn, Lutz, Juergen, Niklas Thon, Hans A. Kretzschmar, Kreth, Friedrich W., Egensperger, Rupert, Hinske Ludwig C., Hinske, Ludwig Christian, Ludwig C Hinske, Sabina Eigenbrod, Tonn Joerg C., Ledderose, Carola, Simone Kreth   +35 more
core   +1 more source

Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes

Cell Reports, 2019
Summary: Altered DNA methylation plays an important role in the onset and progression of kidney disease. However, little is known about how the changes arise in disease states.
Akihito Hishikawa, Kaori Hayashi, Takaya Abe, Mari Kaneko, Hideki Yokoi, Tatsuhiko Azegami, Mari Nakamura, Norifumi Yoshimoto, Takeshi Kanda, Yusuke Sakamaki, Hiroshi Itoh   +10 more
doaj   +1 more source

Insights into genotoxic effects of electromagnetic fields [PDF]

, 2008
The increasing use of appliances, which generate electromagnetic fields (EMFs), has provoked public concern about their safety. Scientific research into possible health effects however produced conflicting results.
Focke, Frauke
core   +1 more source

Epigenetic regulation during fetal femur development: DNA methylation matters [PDF]

, 2013
Epigenetic modifications are heritable changes in gene expression without changes in DNA sequence. DNA methylation has been implicated in the control of several cellular processes including differentiation, gene regulation, development, genomic ...
Oreffo Richard O. C., Oreffo, Richard O. C., Antonio Gonzalez, González Martínez-Pedrayo, Antonio, Imagawa, K., Richard O C Oreffo, de Andrés María C., Gonzalez, A., Roach Helmtrud I., Wilson, David I., Kingham, Emmajayne, Oreffo, R.O., Kingham Emmajayne, Helmtrud I Roach, Oreffo, Richard O C, Gomez-Reino, J.J., Emmajayne Kingham, Kei Imagawa, María C de Andrés, Wilson, D.I., Roach, Helmtrud I, Wilson David I., de Andrés, María C., Imagawa, Kei, Roach, Helmtrud I., De Andrés González, Mª Carmen, Imagawa Kei, Wilson, David I, Neves, Nuno M., David I Wilson, Gonzalez, Antonio, Roach, H.I., Kingham, E., Gonzalez Antonio, de Andrés, M.C.   +34 more
core   +1 more source

Dynamic changes of DNA methylation induced by benzo(a)pyrene in cancer

Genes and Environment, 2023
Benzo(a)pyrene (BaP), the earliest and most significant carcinogen among polycyclic aromatic hydrocarbons (PAHs), has been found in foods, tobacco smoke, and automobiles exhaust, etc.
Huizeng Wang, Bingchun Liu, Hong Chen, Peixin Xu, Huiting Xue, Jianlong Yuan   +5 more
doaj   +1 more source

Association of glomerular DNA damage and DNA methylation with one-year eGFR decline in IgA nephropathy

Scientific Reports, 2020
Accumulation of DNA double-strand breaks (DSBs) is linked to aging and age-related diseases. We recently reported the possible association of DNA DSBs with altered DNA methylation in murine models of kidney disease.
Kaori Hayashi, Akihito Hishikawa, A. Hashiguchi, T. Azegami, Norifumi Yoshimoto, Ran Nakamichi, H. Tokuyama, H. Itoh   +7 more
semanticscholar   +1 more source