Results 31 to 40 of about 1,873,698 (292)
DNA Repair: Bioinformatics Helps Reverse Methylation Damage [PDF]
Current Biology, 2002 Recent work has uncovered a novel DNA repair enzyme: the AlkB protein of Escherichia coli, which oxidises the methyl groups of 1-methyladenine and 3-methylcytosine to hydroxymethyl moieties; the oxidised groups are subsequently released as formaldehyde, regenerating the unmodified bases.
openaire +5 more sources
Insights into genotoxic effects of electromagnetic fields [PDF]
, 2008 The increasing use of appliances, which generate electromagnetic fields (EMFs), has provoked public concern about their safety. Scientific research into possible health effects however produced conflicting results.
Focke, Frauke
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CpG promoter methylation of the ALKBH3 alkylation repair gene in breast cancer
BMC Cancer, 2017 Background DNA repair of alkylation damage is defective in various cancers. This occurs through somatically acquired inactivation of the MGMT gene in various cancer types, including breast cancers. In addition to MGMT, the two E.
Olafur Andri Stefansson +8 more
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DNMT1-mediated PPARα methylation aggravates damage of retinal tissues in diabetic retinopathy mice
Biological Research, 2021 Background Peroxisome proliferator-activated receptor alpha (PPARα) is associated with diabetic retinopathy (DR), and the underlying mechanism is still unclear. Aim of this work was to investigate the mechanism of PPARα in DR.
Ying Zhu +5 more
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Turnover and function of DNA methylation at transcription factor binding sites [PDF]
, 2014 Cell type identity is largely determined by regulatory networks consistent of various transcription factors. Transcription factor activity requires interaction with DNA and thus critically depends on the accessibility of binding motifs.
Feldmann, Angelika
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The Dnmt3L ADD Domain Controls Cytosine Methylation Establishment during Spermatogenesis [PDF]
, 2015 A critical aspect of mammalian gametogenesis is the reprogramming of genomic DNA methylation. The catalytically inactive adaptor Dnmt3L is essential to ensuring this occurs correctly, but the mechanism by which it functions is unclear.
Robert J. Schmitz +26 more
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Functional Analysis of DNA Methylation in Development and Disease [PDF]
, 2006 The genome of mammals harbors chemical modifications at some cytosine residues in the form of a methyl group. These modified residues, termed 5’-methylcytosines, have been discovered more than 50 years ago (Hotchkiss 1948) and have since been shown to ...
Gaudet, François
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Effect of nickel chloride on Arabidopsis genomic DNA and methylation of 18S rDNA
Electronic Journal of Biotechnology, 2015 Background: In recent years, nickel (Ni) has been widely applied in industrial and agricultural production and has become a kind of environmental pollution. In this study, the effect of nickel chloride (NiCl2) with different concentrations on Arabidopsis
Zhongai Li +3 more
doaj +1 more source
VEZF1 elements mediate protection from DNA methylation [PDF]
, 2010 There is growing consensus that genome organization and long-range gene regulation involves partitioning of the genome into domains of distinct epigenetic chromatin states.
Gowher Humaira +21 more
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