Results 21 to 30 of about 2,934,821 (333)

Correction: DNA Damage, Homology-Directed Repair, and DNA Methylation.

PLoS Genetics, 2017
[This corrects the article DOI: 10.1371/journal.pgen.0030110.].
Concetta Cuozzo, Antonio Porcellini, Tiziana Angrisano, Annalisa Morano, Bongyong Lee, Alba Di Pardo, Samantha Messina, Rodolfo Iuliano, Alfredo Fusco, Maria R Santillo, Mark T Muller, Lorenzo Chiariotti, Max E Gottesman, Enrico V Avvedimento   +13 more
doaj   +3 more sources

Mitochondrial genome undergoes de novo DNA methylation that protects mtDNA against oxidative damage during the peri-implantation window

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance In early mammalian embryos, enhanced mitochondrial oxidative metabolism is a hallmark essential for postimplantation survival and development.
Yuan Yue, L. Ren, Chao Zhang, Kai Miao, Kun Tan, Qianying Yang, Yupei Hu, Guangyin Xi, Gang Luo, Mingyao Yang, Jingyu Zhang, Zhuocheng Hou, L. An, Jianhui Tian   +13 more
semanticscholar   +1 more source

B1 siRNA Increases de novo DNA Methylation of B1 Elements and Promotes Wound Healing in Diabetic Rats

Frontiers in Cell and Developmental Biology, 2022
Alu (B1 in rodents) hypomethylation, commonly found in diabetes mellitus patients, increases DNA damage and, consequently, delays the healing process.
Sakawdaurn Yasom, Sakawdaurn Yasom, Wilunplus Khumsri, Wilunplus Khumsri, Papatson Boonsongserm, Nakarin Kitkumthorn, Preecha Ruangvejvorachai, Apasee Sooksamran, Rujira Wanotayan, Apiwat Mutirangura   +9 more
doaj   +1 more source

Hypermethylation of genes detected in urine from Ghanaian adults with bladder pathology associated with Schistosoma haematobium infection. [PDF]

PLoS ONE, 2013
Schistosoma haematobium is associated with chronic bladder damage and may subsequently induce bladder cancer in humans, thus posing a serious threat where the parasite is endemic.
Xiaoli Zhong, Sumit Isharwal, Jean M Naples, Clive Shiff, Robert W Veltri, Chunbo Shao, Kwabena M Bosompem, David Sidransky, Mohammad O Hoque   +8 more
doaj   +1 more source

Methylation of the Suppressor Gene p16INK4a: Mechanism and Consequences

Biomolecules, 2020
Tumor suppressor genes in the CDKN2A/B locus (p15INK4b, p16INK4a, and p14ARF) function as biological barriers to transformation and are the most frequently silenced or deleted genes in human cancers.
Alfonso Tramontano, Francesca Ludovica Boffo, Giusi Russo, Mariarosaria De Rosa, Ilaria Iodice, Antonio Pezone   +5 more
doaj   +1 more source

UHRF1-induced connexin26 methylation is involved in hearing damage triggered by intermittent hypoxia in neonatal rats

Open Medicine, 2023
Ubiquitin-like with plant homeodomain and ring finger domains 1 (UHRF1) promotes the maintenance of established patterns of DNA methylation in mammalian cells.
Zhang Xingang, Zheng Jishan, Xu Huiqing, Ma Zhaoxin   +3 more
doaj   +1 more source

DNA adenine methylation in eukaryotes: Enzymatic mark or a form of DNA damage?

Bioessays, 2020
6‐methyladenine (6mA) is fairly abundant in nuclear DNA of basal fungi, ciliates and green algae. In these organisms, 6mA is maintained near transcription start sites in ApT context by a parental‐strand instruction dependent maintenance methyltransferase
M. Bochtler, H. Fernandes
semanticscholar   +1 more source

Apoptosis and DNA methylation [PDF]

, 2011
Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can ...
Meng, Huan X, Nestor, Colm, Reddington, James P, Richard R. Meehan, Harrison, David J, Dunican, Donncha S, Monika Madej, Hackett, James A, Dunican, Donncha S; id_orcid, James P. Reddington, Madej, Monika, Colm Nestor, Sari Pennings, Meehan, Richard R, Pennings, Sari, James A. Hackett, Huan X. Meng, David J. Harrison, Donncha S. Dunican   +18 more
core   +1 more source

Multiomics analysis of adaptation to repeated DNA damage in prostate cancer cells

Epigenetics, 2023
DNA damage is frequently utilized as the basis for cancer therapies; however, resistance to DNA damage remains one of the biggest challenges for successful treatment outcomes. Critically, the molecular drivers behind resistance are poorly understood.
D. Challis, T. Lippis, R. Wilson, E. Wilkinson, J. Dickinson, A. Black, I. Azimi, A. Holloway, P. Taberlay, K. Brettingham-Moore   +9 more
doaj   +1 more source

Associations Between Methylation of Paternally Expressed Gene 3 (PEG3), Cervical Intraepithelial Neoplasia and Invasive Cervical Cancer. [PDF]

, 2013
Cytology-based screening for invasive cervical cancer (ICC) lacks sensitivity and specificity to discriminate between cervical intraepithelial neoplasia (CIN) likely to persist or progress from cases likely to resolve.
Bartlett, John A., Britta Swai, Smith Jennifer S., Obure, Joseph, Obure Joseph, Vasquez, Brandi, Nye, Monica D., Swai, Britta, Gammon, Marilie D, Hoyo Cathrine, Frances Wang, Vasquez Brandi, Zhiqing Huang, Oneko Olola, Overcash, Francine, Oneko, Olola, Vidal Adriana C., Brenda Hernandez, Bartlett John A., Gammon Marilie D., Smith, Jennifer S, Francine Overcash, Nye, Monica D, Brandi Vasquez, Monica D Nye, Joseph Obure, Marilie D Gammon, Huang Zhiqing, Swai Britta, Olola Oneko, Mlay Pendo, Hernandez, Brenda, Wang Frances, Hernandez Brenda, Hoyo, Cathrine, Adriana C Vidal, Mlay, Pendo, Murphy, Susan K, Murphy, Susan K., Vidal, Adriana C, Pendo Mlay, Susan K Murphy, Smith, Jennifer S., Cathrine Hoyo, Gammon, Marilie D., Nye Monica D., Jennifer S Smith, Murphy Susan K., Wang, Frances, John A Bartlett, Huang, Zhiqing, Overcash Francine, Vidal, Adriana C., Bartlett, John A   +53 more
core   +1 more source