Results 21 to 30 of about 134,759 (258)

CpG promoter methylation of the ALKBH3 alkylation repair gene in breast cancer

BMC Cancer, 2017
Background DNA repair of alkylation damage is defective in various cancers. This occurs through somatically acquired inactivation of the MGMT gene in various cancer types, including breast cancers. In addition to MGMT, the two E.
Olafur Andri Stefansson, Stefan Hermanowicz, Jasper van der Horst, Holmfridur Hilmarsdottir, Zuzanna Staszczak, Jon Gunnlaugur Jonasson, Laufey Tryggvadottir, Thorkell Gudjonsson, Stefan Sigurdsson   +8 more
doaj   +1 more source

DNMT1-mediated PPARα methylation aggravates damage of retinal tissues in diabetic retinopathy mice

Biological Research, 2021
Background Peroxisome proliferator-activated receptor alpha (PPARα) is associated with diabetic retinopathy (DR), and the underlying mechanism is still unclear. Aim of this work was to investigate the mechanism of PPARα in DR.
Ying Zhu, Xinru Wang, Xiaoyun Zhou, Lexi Ding, Dan Liu, Huizhuo Xu   +5 more
doaj   +1 more source

Effect of nickel chloride on Arabidopsis genomic DNA and methylation of 18S rDNA

Electronic Journal of Biotechnology, 2015
Background: In recent years, nickel (Ni) has been widely applied in industrial and agricultural production and has become a kind of environmental pollution. In this study, the effect of nickel chloride (NiCl2) with different concentrations on Arabidopsis
Zhongai Li, Xin Chen, Suoping Li, Zicheng Wang   +3 more
doaj   +1 more source

Correlation of chromosome damage and promoter methylation status of the DNA repair genes MGMT and hMLH1 in Chinese vinyl chloride monomer (VCM)-exposed workers

International Journal of Occupational Medicine and Environmental Health, 2013
Objective: To explore the association of the methylation status of MGMT and hMLH1 with chromosome damage induced by vinyl chloride monomer (VCM). Materials and Methods: Methylation of MGMT and hMLH1 was measured in 101 VCM-exposed workers by methylation ...
Fen Wu, Jing Liu, Yu-Lan Qiu, Wei Wang, Shou-Min Zhu, Pin Sun, Wen-Bin Miao, Yong-Liang Li, Paul W. Brandt-Rauf, Zhao-Lin Xia   +9 more
doaj   +1 more source

DNA DAMAGE BINDING PROTEIN2 Shapes the DNA Methylation Landscape [PDF]

The Plant Cell, 2016
In eukaryotes, DNA repair pathways help to maintain genome integrity and epigenomic patterns. However, the factors at the nexus of DNA repair and chromatin modification/remodeling remain poorly characterized. Here, we uncover a previously unrecognized interplay between the DNA repair factor DNA DAMAGE BINDING PROTEIN2 (DDB2) and the DNA methylation ...
Schalk, Catherine, Drevensek, Stéphanie, Kramdi, Amira, Kassam, Mohamed, Ahmed, Ikhlak, Cognat, Valerie, Graindorge, Stefanie, Bergdoll, Marc, Baumberger, Nicolas, Heintz, Dimitri, Bowler, Chris, Genschik, Pascal, Barneche, Fredy, Colot, Vincent, Molinier, Jean   +14 more
openaire   +3 more sources

Maternal exposure to genistein during pregnancy and oxidative DNA damage in testes of male mouse offspring

Frontiers in Nutrition, 2022
BackgroundGenistein is a dietary supplement with phyto-estrogenic properties. Therefore, high intake of genistein during pregnancy may have adverse effects on the genetic integrity of testes and germ cells of male offspring.
Roger W. L. Godschalk, Margit C. M. Janssen, Kimberly Vanhees, Sahar Barjesteh van Waalwijk van Doorn-Khosrovani, Frederik-Jan van Schooten   +4 more
doaj   +1 more source

The role of H3K79 methylation in transcription and the DNA damage response

Mutation Research/Reviews in Mutation Research, 2019
Chromatin plays a critical role in organizing and protecting DNA. However, chromatin acts as an impediment for transcription and DNA repair. Histone modifications, such as H3K79 methylation, promote transcription and genomic stability by enhancing transcription elongation and by serving as landing sites for proteins involved in the DNA damage response.
Mats, Ljungman, Luke, Parks, Radhika, Hulbatte, Karan, Bedi   +3 more
openaire   +3 more sources

Perturbed DNA methylation by Gadd45b induces chromatin disorganization, DNA strand breaks and dopaminergic neuron death

iScience, 2021
Summary: Age is a major risk factor for neurodegenerative diseases like Parkinson’s disease, but few studies have explored the contribution of key hallmarks of aging, namely DNA methylation changes and heterochromatin destructuration, in the ...
Camille Ravel-Godreuil, Olivia Massiani-Beaudoin, Philippe Mailly, Alain Prochiantz, Rajiv L. Joshi, Julia Fuchs   +5 more
doaj   +1 more source

Effects of curcumin on methyl methanesulfonate damage to mouse kidney

Biotechnic & Histochemistry, 2015
Methylmethane sulfonate (MMS) is an alkylating agent that may react with DNA and damage it. We investigated histological changes and apoptosis caused by MMS and the effects of curcumin on MMS treated mouse kidneys. Twenty-four mice were divided into four equal groups: controls injected with saline, a group injected with 40 mg/kg MMS, a group injected ...
CÜCE, Gökhan, ÇETİNKAYA, Seda, İŞİTEZ, Nilay, KÜÇÇÜKTÜRK, Serkan, SÖZEN, Mehmet Enes, DEMİREL, Hasan Hüseyin, KALKAN, Sinan, CİĞERCİ, İbrahim Hakkı   +7 more
openaire   +3 more sources

Methylation-Acetylation Interplay Activates p53 in Response to DNA Damage [PDF]

Molecular and Cellular Biology, 2007
p53, an important tumor suppressor protein, exerts its function mostly as a sequence-specific transcription factor and is subjected to multiple posttranslational modifications in response to genotoxic stress. Recently, we discovered that lysine methylation of p53 at K372 by Set7/9 (also known as SET7 and Set9) is important for transcriptional ...
Gleb S, Ivanov, Tatyana, Ivanova, Julia, Kurash, Alexey, Ivanov, Sergey, Chuikov, Farid, Gizatullin, Enrique M, Herrera-Medina, Frank, Rauscher, Danny, Reinberg, Nickolai A, Barlev   +9 more
openaire   +2 more sources