Results 11 to 20 of about 1,873,698 (292)

Correlation of chromosome damage and promoter methylation status of the DNA repair genes MGMT and hMLH1 in Chinese vinyl chloride monomer (VCM)-exposed workers [PDF]

International Journal of Occupational Medicine and Environmental Health, 2013
Objective: To explore the association of the methylation status of MGMT and hMLH1 with chromosome damage induced by vinyl chloride monomer (VCM). Materials and Methods: Methylation of MGMT and hMLH1 was measured in 101 VCM-exposed workers by methylation ...
Fen Wu, Jing Liu, Yu-Lan Qiu, Wei Wang, Shou-Min Zhu, Pin Sun, Wen-Bin Miao, Yong-Liang Li, Paul W. Brandt-Rauf, Zhao-Lin Xia   +9 more
doaj   +3 more sources

Methylation-Acetylation Interplay Activates p53 in Response to DNA Damage [PDF]

Molecular and Cellular Biology, 2007
p53, an important tumor suppressor protein, exerts its function mostly as a sequence-specific transcription factor and is subjected to multiple posttranslational modifications in response to genotoxic stress. Recently, we discovered that lysine methylation of p53 at K372 by Set7/9 (also known as SET7 and Set9) is important for transcriptional ...
Gleb S, Ivanov, Tatyana, Ivanova, Julia, Kurash, Alexey, Ivanov, Sergey, Chuikov, Farid, Gizatullin, Enrique M, Herrera-Medina, Frank, Rauscher, Danny, Reinberg, Nickolai A, Barlev   +9 more
openaire   +3 more sources

DNA methylation protects cancer cells against senescence

Nature Communications
Inhibitors of DNA methylation such as 5-aza-deoxycytidine are widely used in experimental and clinical settings. However, their mechanism of action is such that DNA damage inevitably co-occurs with loss of DNA methylation, making it challenging to ...
Xiaoying Chen, Kosuke Yamaguchi, Brianna Rodgers, Delphine Goehrig, David Vindrieux, Xavier Lahaye, Matthieu Nolot, Laure Ferry, Sophie Lanciano, Nadine Martin, Pierre Dubus, Fumihito Miura, Takashi Ito, Gael Cristofari, Nicolas Manel, Masato T. Kanemaki, David Bernard, Pierre-Antoine Defossez   +17 more
doaj   +2 more sources

PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage [PDF]

Cancer Discovery, 2019
Abstract The function of PTEN in the cytoplasm largely depends on its lipid-phosphatase activity, though which it antagonizes the PI3K–AKT oncogenic pathway. However, molecular mechanisms underlying the role of PTEN in the nucleus remain largely elusive.
Jinfang Zhang, Yu-Ru Lee, Fabin Dang, Wenjian Gan, Archita Venugopal Menon, Jesse M. Katon, Chih-Hung Hsu, John M. Asara, Priyanka Tibarewal, Nicholas R. Leslie, Yang Shi, Pier Paolo Pandolfi, Wenyi Wei   +12 more
openaire   +4 more sources

Promoter Methylation Changes in DNA Damage-Response Genes in Ovarian Cancer and Their Correlation with Prognosis

Clinical and Experimental Obstetrics & Gynecology
Background: Ovarian cancer has a poor prognosis, and DNA damage-response (DDR) genes are associated with both its occurrence and prognosis. However, previous studies have mostly focused on genetic mutations, with no clear conclusions on epigenetic ...
Wanhong He, Haijun Zhu, Sufen Zhang, Guang Shu, Han Lei, Gang Yin, Xiaohua Ni, Maonan Wang, Qihan Wu   +8 more
doaj   +2 more sources

Maternal nutritional status, C1 metabolism and offspring DNA methylation: a review of current evidence in human subjects. [PDF]

, 2011
: Evidence is growing for the long-term effects of environmental factors during early-life on later disease susceptibility. It is believed that epigenetic mechanisms (changes in gene function not mediated by DNA sequence alteration), particularly DNA ...
Dominguez Salas, Paula, Dominguez-Salas, P, Prentice, AM, Sophie E. Moore, Cox, SE, Dominguez-Salas, Paula, Prentice, Andrew M, Hennig, Branwen J, Paula Dominguez-Salas, Andrew M. Prentice, Moore, SE, Moore, Sophie E, Hennig, BJ, Cox, Sharon E, Prentice, Andrew M., Moore, Sophie E., Hennig, Branwen J., Branwen J. Hennig, Sharon E. Cox, Cox, Sharon E.   +19 more
core   +3 more sources

UHRF1-induced connexin26 methylation is involved in hearing damage triggered by intermittent hypoxia in neonatal rats

Open Medicine, 2023
Ubiquitin-like with plant homeodomain and ring finger domains 1 (UHRF1) promotes the maintenance of established patterns of DNA methylation in mammalian cells.
Zhang Xingang, Zheng Jishan, Xu Huiqing, Ma Zhaoxin   +3 more
doaj   +1 more source

Apoptosis and DNA methylation [PDF]

, 2011
Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can ...
Meng, Huan X, Nestor, Colm, Reddington, James P, Richard R. Meehan, Harrison, David J, Dunican, Donncha S, Monika Madej, Hackett, James A, Dunican, Donncha S; id_orcid, James P. Reddington, Madej, Monika, Colm Nestor, Sari Pennings, Meehan, Richard R, Pennings, Sari, James A. Hackett, Huan X. Meng, David J. Harrison, Donncha S. Dunican, Harrison, David J; id_orcid   +19 more
core   +1 more source

Multiomics analysis of adaptation to repeated DNA damage in prostate cancer cells

Epigenetics, 2023
DNA damage is frequently utilized as the basis for cancer therapies; however, resistance to DNA damage remains one of the biggest challenges for successful treatment outcomes. Critically, the molecular drivers behind resistance are poorly understood.
D. Challis, T. Lippis, R. Wilson, E. Wilkinson, J. Dickinson, A. Black, I. Azimi, A. Holloway, P. Taberlay, K. Brettingham-Moore   +9 more
doaj   +1 more source

In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases [PDF]

, 2012
The enzymatic control of the setting and maintenance of symmetric and non-symmetric DNA methylation patterns in a particular genome context is not well understood.
Julia Arand (155279), Meissner, A, Meilinger, D., Arand, Julia, Leonhardt, Heinrich, Jenuwein, Thomas, Wolf, Verena, Thomas Jenuwein (70681), Tommy Karius, David Spieler, Jenuwein, T., Xu, G, Tommy Karius (155285), Walter, Jörn, Wolf, V., Branco, MR, Leonhardt, H, Spieler, D, Branco, Miguel R., Meilinger, Daniela, Julia Arand, Jörn Walter, Walter, Joern, Jörn Walter (37094), Walter, J, Miguel R. Branco (42502), Verena Wolf, Karius, T, Meissner, Alexander, Arand, J, Alexander Meissner (11643), Meilinger, D, Daniela Meilinger, Heinrich Leonhardt (18589), Verena Wolf (155286), Daniela Meilinger (107843), Arand, J., Jenuwein, T, Miguel R Branco, Thomas Jenuwein, Guoliang Xu, Alexander Meissner, Walter, J., Meissner, A., Heinrich Leonhardt, Karius, Tommy, Guoliang Xu (67200), Spieler, David, Karius, T., Xu, Guoliang, David Spieler (155282), Branco, M., Xu, G., Wolf, V, Spieler, D., Leonhardt, H.   +55 more
core   +1 more source