Results 11 to 20 of about 134,759 (258)
RETRACTED: DNA damage, homology-directed repair, and DNA methylation.
PLoS Genetics, 2007 To explore the link between DNA damage and gene silencing, we induced a DNA double-strand break in the genome of Hela or mouse embryonic stem (ES) cells using I-SceI restriction endonuclease. The I-SceI site lies within one copy of two inactivated tandem
Concetta Cuozzo +13 more
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Correction: DNA Damage, Homology-Directed Repair, and DNA Methylation.
PLoS Genetics, 2017 [This corrects the article DOI: 10.1371/journal.pgen.0030110.].
Concetta Cuozzo +13 more
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DNA Damage Repair and DNA Methylation in the Kidney [PDF]
American Journal of Nephrology, 2019 The DNA repair system is essential for the maintenance of genome integrity and is mainly investigated in the areas of aging and cancer. The DNA repair system is strikingly cell-type specific, depending on the expression of DNA repair factors; therefore, different DNA repair systems may exist in each type of kidney cell.
Kaori, Hayashi +2 more
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Repurposing the Damage Repair Protein Methyl Guanine Methyl Transferase as a Ligand Inducible Fusion Degron [PDF]
ACS Chemical Biology, 2022 We successfully repurpose the DNA repair protein methylguanine methyltransferase (MGMT) as an inducible degron for protein fusions. MGMT is a suicide protein that removes alkyl groups from the O6 position of guanine (O6G) and is thereafter quickly degraded by the ubiquitin proteasome pathway (UPP). Starting with MGMT pseudosubstrates (benzylguanine and
Murawska, Gosia M. +13 more
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Repair of Methylation Damage in DNA and RNA by Mammalian AlkB Homologues [PDF]
Journal of Biological Chemistry, 2005 Human and Escherichia coli derivatives of AlkB enzymes remove methyl groups from 1-methyladenine and 3-methylcytosine in nucleic acids via an oxidative mechanism that releases the methyl group as formaldehyde. In this report, we demonstrate that the mouse homologues of the alpha-ketoglutarate Fe(II) oxygen-dependent enzymes mAbh2 and Abh3 have ...
Lee, Dong-Hyun +5 more
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Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes
Cell Reports, 2019 Summary: Altered DNA methylation plays an important role in the onset and progression of kidney disease. However, little is known about how the changes arise in disease states.
Akihito Hishikawa +10 more
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Dynamic changes of DNA methylation induced by benzo(a)pyrene in cancer
Genes and Environment, 2023 Benzo(a)pyrene (BaP), the earliest and most significant carcinogen among polycyclic aromatic hydrocarbons (PAHs), has been found in foods, tobacco smoke, and automobiles exhaust, etc.
Huizeng Wang +5 more
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Update on DNA methylation in UV radiation-related skin diseases
Pifu-xingbing zhenliaoxue zazhi, 2023 DNA methylation is a common epigenetic phenomenon that changes genetic expression without altering the DNA sequence. With deepening research on DNA methylation, more and more variable positions of methylation have been identified in a variety of diseases(
Wenting CHEN, Xinni ZHONG, Wei LI
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DNA Repair: Bioinformatics Helps Reverse Methylation Damage [PDF]
Current Biology, 2002 Recent work has uncovered a novel DNA repair enzyme: the AlkB protein of Escherichia coli, which oxidises the methyl groups of 1-methyladenine and 3-methylcytosine to hydroxymethyl moieties; the oxidised groups are subsequently released as formaldehyde, regenerating the unmodified bases.
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PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage [PDF]
Cancer Discovery, 2019 Abstract The function of PTEN in the cytoplasm largely depends on its lipid-phosphatase activity, though which it antagonizes the PI3K–AKT oncogenic pathway. However, molecular mechanisms underlying the role of PTEN in the nucleus remain largely elusive.
Jinfang Zhang +12 more
openaire +2 more sources