Results 11 to 20 of about 2,934,821 (333)

Histone methylation and the DNA damage response [PDF]

Mutation Research - Reviews in Mutation Research, 2019
Preserving genome function and stability are paramount for ensuring cellular homeostasis, an imbalance in which can promote diseases including cancer. In the presence of DNA lesions, cells activate pathways referred to as the DNA damage response (DDR). As nuclear DNA is bound by histone proteins and organized into chromatin in eukaryotes, DDR pathways ...
Fade Gong, Kyle M Miller
exaly   +3 more sources

Regular, Intense Exercise Training as a Healthy Aging Lifestyle Strategy: Preventing DNA Damage, Telomere Shortening and Adverse DNA Methylation Changes Over a Lifetime [PDF]

Frontiers in Genetics, 2021
Exercise training is one of the few therapeutic interventions that improves health span by delaying the onset of age-related diseases and preventing early death.
M. Sellami, Nicola Luigi Bragazzi, Mohammad Shoaib Prince, J. Denham, Mohamed A. Elrayess   +4 more
semanticscholar   +2 more sources

Correlation of chromosome damage and promoter methylation status of the DNA repair genes MGMT and hMLH1 in Chinese vinyl chloride monomer (VCM)-exposed workers [PDF]

International Journal of Occupational Medicine and Environmental Health, 2013
Objective: To explore the association of the methylation status of MGMT and hMLH1 with chromosome damage induced by vinyl chloride monomer (VCM). Materials and Methods: Methylation of MGMT and hMLH1 was measured in 101 VCM-exposed workers by methylation ...
Fen Wu, Jing Liu, Yu-Lan Qiu, Wei Wang, Shou-Min Zhu, Pin Sun, Wen-Bin Miao, Yong-Liang Li, Paul W. Brandt-Rauf, Zhao-Lin Xia   +9 more
doaj   +2 more sources

The role of H3K79 methylation in transcription and the DNA damage response.

Mutation Research/Reviews in Mutation Research, 2019
Chromatin plays a critical role in organizing and protecting DNA. However, chromatin acts as an impediment for transcription and DNA repair. Histone modifications, such as H3K79 methylation, promote transcription and genomic stability by enhancing ...
M. Ljungman, Luke Parks, R. Hulbatte, Karan Bedi   +3 more
semanticscholar   +4 more sources

CYP1A1 methylation mediates the effect of smoking and occupational polycyclic aromatic hydrocarbons co-exposure on oxidative DNA damage among Chinese coke-oven workers

Environmental Health, 2019
Background Multiple factors, including co-exposure between lifestyle and environmental risks, are important in susceptibility to oxidative DNA damage. However, the underlying mechanism is not fully understood.
Yanli Liu, Xuejing Li, Bin Zhang, Ye Fu, Aimin Yang, Hongjie Zhang, Huitao Zhang, Yingying Niu, Jisheng Nie, Jin Yang   +9 more
doaj   +2 more sources

Methylation levels ofIGF2andKCNQ1in spermatozoa from infertile men are associated with sperm DNA damage

Andrologia, 2019
Abnormal imprinted genes methylation in spermatozoa has been shown to be associated with subfertility. However, the relationship between sperm DNA damage and specific imprinted genes methylation remains unclear. In this study, DNA methylation levels were
Wuhua Ni, Chengshuang Pan, Qianjin Fei   +2 more
exaly   +2 more sources

RETRACTED: DNA damage, homology-directed repair, and DNA methylation.

PLoS Genetics, 2007
To explore the link between DNA damage and gene silencing, we induced a DNA double-strand break in the genome of Hela or mouse embryonic stem (ES) cells using I-SceI restriction endonuclease. The I-SceI site lies within one copy of two inactivated tandem
Concetta Cuozzo, Antonio Porcellini, Tiziana Angrisano, Annalisa Morano, Bongyong Lee, Alba Di Pardo, Samantha Messina, Rodolfo Iuliano, Alfredo Fusco, Maria R Santillo, Mark T Muller, Lorenzo Chiariotti, Max E Gottesman, Enrico V Avvedimento   +13 more
doaj   +8 more sources

Methylation-Acetylation Interplay Activates p53 in Response to DNA Damage [PDF]

Molecular and Cellular Biology, 2007
p53, an important tumor suppressor protein, exerts its function mostly as a sequence-specific transcription factor and is subjected to multiple posttranslational modifications in response to genotoxic stress. Recently, we discovered that lysine methylation of p53 at K372 by Set7/9 (also known as SET7 and Set9) is important for transcriptional ...
Gleb S, Ivanov, Tatyana, Ivanova, Julia, Kurash, Alexey, Ivanov, Sergey, Chuikov, Farid, Gizatullin, Enrique M, Herrera-Medina, Frank, Rauscher, Danny, Reinberg, Nickolai A, Barlev   +9 more
openaire   +3 more sources

UV-induced damage to DNA: effect of cytosine methylation on pyrimidine dimerization [PDF]

Signal Transduction and Targeted Therapy, 2017
Methylation/demethylation of cytosine plays an important role in epigenetic signaling, the reversibility of epigenetic modifications offering important opportunities for targeted therapies.
Lara Martínez-Fernández, A. Banyasz, L. Esposito, D. Markovitsi, R. Improta   +4 more
semanticscholar   +5 more sources

DNA DAMAGE BINDING PROTEIN2 Shapes the DNA Methylation Landscape [PDF]

The Plant Cell, 2016
In eukaryotes, DNA repair pathways help to maintain genome integrity and epigenomic patterns. However, the factors at the nexus of DNA repair and chromatin modification/remodeling remain poorly characterized. Here, we uncover a previously unrecognized interplay between the DNA repair factor DNA DAMAGE BINDING PROTEIN2 (DDB2) and the DNA methylation ...
Schalk, Catherine, Drevensek, Stéphanie, Kramdi, Amira, Kassam, Mohamed, Ahmed, Ikhlak, Cognat, Valerie, Graindorge, Stefanie, Bergdoll, Marc, Baumberger, Nicolas, Heintz, Dimitri, Bowler, Chris, Genschik, Pascal, Barneche, Fredy, Colot, Vincent, Molinier, Jean   +14 more
openaire   +4 more sources