Results 61 to 70 of about 2,934,821 (333)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage

Nucleic Acids Research, 2012
The Escherichia coli AlkB protein (EcAlkB) is a DNA repair enzyme which reverses methylation damage such as 1-methyladenine (1-meA) and 3-methylcytosine (3-meC). The mammalian AlkB homologues ALKBH2 and ALKBH3 display EcAlkB-like repair activity in vitro,
Trine J. Meza, M. N. Moen, C. Vågbø, H. Krokan, A. Klungland, P. Grini, P. Falnes   +6 more
semanticscholar   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Metabolism of low-dose inorganic arsenic in a central European population: influence of sex and genetic polymorphisms. [PDF]

, 2007
BACKGROUND: There is a wide variation in susceptibility to health effects of arsenic, which, in part, may be due to differences in arsenic metabolism.
Eugen Gurzau, Vahter, Marie, Gurzau, Eugen, Rajiv Kumar, Goessler, Walter, Ranjit Thirumaran, Leonardi, Giovanni, Kumar, Rajiv, Marie Vahter, Tony Fletcher, Anna-Lena Lindberg, Koppova, Kvetoslava, Giovanni Leonardi, Fletcher, Tony, Walter Goessler, Peter Rudnai, Kvetoslava Koppova, Rudnai, Peter, Thirumaran, Ranjit, Lindberg, Anna-Lena   +19 more
core   +1 more source

Retraction: DNA Damage, Homology-Directed Repair, and DNA Methylation

PLoS Genetics
PLOS Genetics Editors
doaj   +5 more sources

Predicting exacerbation of renal function by DNA methylation clock and DNA damage of urinary shedding cells: a pilot study

Scientific Reports
Recent reports have shown the feasibility of measuring biological age from DNA methylation levels in blood cells from specific regions identified by machine learning, collectively known as the epigenetic clock or DNA methylation clock.
Akihito Hishikawa, Erina Sugita Nishimura, Norifumi Yoshimoto, Ran Nakamichi, Eriko Yoshida Hama, Wataru Ito, Tomomi Maruki, Kengo Nagashima, Ryoko Shimizu-Hirota, Hiromasa Takaishi, Hiroshi Itoh, Kaori Hayashi   +11 more
doaj   +1 more source

Cadmium disturbs epigenetic modification and induces DNA damage in mouse preimplantation embryos

Ecotoxicology and Environmental Safety, 2021
Cadmium is an environmental pollutant that has extensive deleterious effects on the reproductive system. However, the mechanisms underlying the effects of cadmium on preimplantation embryos are unclear.
Jiaqiao Zhu, Zhutao Huang, Fan Yang, Min Zhu, Jiangqin Cao, Jiali Chen, Yan Lin, Shuai Guo, Junwei Li, Zongping Liu   +9 more
doaj   +1 more source

Monitoring liver damage using hepatocyte-specific methylation markers in cell-free circulating DNA.

JCI Insight, 2018
Liver damage is typically inferred from serum measurements of cytoplasmic liver enzymes. DNA molecules released from dying hepatocytes are an alternative biomarker, unexplored so far, potentially allowing for quantitative assessment of liver cell death ...
Roni Lehmann-Werman, J. Magenheim, J. Moss, D. Neiman, Ofri Abraham, Sheina Piyanzin, Hai Zemmour, Ilana Fox, T. Dor, M. Grompe, G. Landesberg, Bao-Li Loza, A. Shaked, K. Olthoff, B. Glaser, R. Shemer, Y. Dor   +16 more
semanticscholar   +1 more source

Repair of Alkylation Damage: Stability of Methyl Groups in Bacillus subtilis Treated with Methyl Methanesulfonate [PDF]

Journal of Bacteriology, 1970
Bacillus subtilis was not inactivated and was able to replicate even though approximately 3 × 10 4 methyl groups added by methyl methanesulfonate (MMS) were bound to the deoxyribonucleic acid (DNA) of each organism.
L, Prakash, B, Strauss
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source