Results 61 to 70 of about 1,873,698 (292)

Widespread prevalence of a methylation-dependent switch to activate an essential DNA damage response in bacteria.

PLoS Biology
DNA methylation plays central roles in diverse cellular processes, ranging from error-correction during replication to regulation of bacterial defense mechanisms. Nevertheless, certain aberrant methylation modifications can have lethal consequences.
Aditya Kamat, Ngat T Tran, Mohak Sharda, Neha Sontakke, Tung B K Le, Anjana Badrinarayanan   +5 more
doaj   +1 more source

Mechanisms of DNA damage by photoexcited 9-methyl-β-carbolines

Organic & Biomolecular Chemistry, 2013
It has been well documented that β-carboline alkaloids, particularly the 9-methyl derivatives, are efficient photosensitizers. However, structure-activity relationships are missing and the photochemical mechanisms involved in the DNA photodamage still remain unknown.
Vignoni, Mariana, Rasse Suriani, Federico Ariel Osvaldo, Butzbach, Kathrin, Erra Balsells, Rosa, Epe, Bernd, Cabrerizo, Franco Martín   +5 more
openaire   +3 more sources

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

DNA methylation patterns in cord blood DNA and body size in childhood. [PDF]

, 2012
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.BACKGROUND ...
Pearce, M., Mark S. Pearce (177539), Ness, Andy R, Caroline L Relton, St Pourcain, B., Joseph Trakalo (177545), Shaheen Seif O., Embleton, N., Swan, DC, Ness, AR, George Davey Smith (82619), Seif O. Shaheen (177559), Shaheen, S., Relton, Caroline L, Ring, SM, Relton, C., Jon H Tobias, Swan, D., Sayers, AE, Alexandra Groom, Caroline L. Relton (174120), Susan M. Ring (116089), Embleton Nicholas D., Alexandra Groom (174101), Andy R Ness, Andy R. Ness (177551), Ring Susan M., Beate St. Pourcain (152905), Sayers, Adrian E, Tobias Jon H., Ness Andy R., Trakalo, J, St Pourcain, B, Sayers Adrian E., Groom, A., Tobias, Jonathan H, Relton Caroline L., St. Pourcain Beate, St Pourcain, M U B, Nicholas D Embleton, Tobias, J., Jon H. Tobias (153172), Northstone, K., Beate St Pourcain, Northstone, K, Davey Smith George, Trakalo Joseph, Groom Alexandra, Joseph Trakalo, Sayers, A., Kate Northstone (74777), Tobias, JH, Davey Smith, George, Groom, A, Ring, Susan M, Davey Smith, G, Pearce, MS, Northstone, Kate, Nicholas D. Embleton (177535), Susan M Ring, Pearce Mark S., Daniel C Swan, Ness, A., Swan Daniel C., Mark S Pearce, Northstone Kate, Relton, CL, Adrian E Sayers, Shaheen, SO, George Davey Smith, Trakalo, J., Adrian E. Sayers (177532), Embleton, ND, Davey Smith, G., Kate Northstone, Seif O Shaheen, Ring, S., Daniel C. Swan (124594)   +77 more
core   +1 more source

Oxidative Stress and DNA Methylation in Prostate Cancer

Obstetrics and Gynecology International, 2010
The protective effects of fruits, vegetables, and other foods on prostate cancer may be due to their antioxidant properties. An imbalance in the oxidative stress/antioxidant status is observed in prostate cancer patients.
Krishna Vanaja Donkena, Charles Y. F. Young, Donald J. Tindall   +2 more
doaj   +1 more source

UV-induced damage to DNA: effect of cytosine methylation on pyrimidine dimerization [PDF]

Signal Transduction and Targeted Therapy, 2017
AbstractMethylation/demethylation of cytosine plays an important role in epigenetic signaling, the reversibility of epigenetic modifications offering important opportunities for targeted therapies. Actually, methylated sites have been correlated with mutational hotspots detected in skin cancers.
MartinezFernandez Lara, Banyasz Akos, Esposito Luciana, Markovitsi Dimitra, Improta Roberto   +4 more
openaire   +4 more sources

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks. [PDF]

, 2012
Recruitment of 53BP1 to chromatin flanking double strand breaks (DSBs) requires γH2AX/MDC1/RNF8-dependent ubiquitination of chromatin and interaction of 53BP1 with histone H4 methylated on lysine 20 (H4K20me). Several histone methyltransferases have been
Guan, Yinghua, Rajendran, Anbazhagan, Jagesh V. Shah (116400), Anyong Xie (116396), Gunnar Schotta (116394), Anbazhagan Rajendran (116388), Yinghua Guan (116385), Anyong Xie, Yinghua Guan, Ralph Scully, Hartlerode, Andrea J., Andrea J Hartlerode, Anbazhagan Rajendran, Gunnar Schotta, Andrea J. Hartlerode, Jagesh V. Shah, Jagesh V Shah, Andrea J. Hartlerode (116383), Ralph Scully (116402), Xie, Anyong, Shah, Jagesh, Ura, Kiyoe, Kiyoe Ura (116391), Scully, Ralph, Kiyoe Ura, Schotta, Gunnar, Shah, Jagesh V., Shah Jagesh V., Hartlerode Andrea J., Schotta Gunnar, Ura Kiyoe, Guan Yinghua, Xie Anyong, Rajendran Anbazhagan, Scully Ralph   +34 more
core   +2 more sources

CYP1A1 methylation mediates the effect of smoking and occupational polycyclic aromatic hydrocarbons co-exposure on oxidative DNA damage among Chinese coke-oven workers

Environmental Health, 2019
Background Multiple factors, including co-exposure between lifestyle and environmental risks, are important in susceptibility to oxidative DNA damage. However, the underlying mechanism is not fully understood.
Yanli Liu, Xuejing Li, Bin Zhang, Ye Fu, Aimin Yang, Hongjie Zhang, Huitao Zhang, Yingying Niu, Jisheng Nie, Jin Yang   +9 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source