Results 71 to 80 of about 2,934,821 (333)

H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization. [PDF]

, 2013
Histone lysine (K) methylation has been shown to play a fundamental role in modulating chromatin architecture and regulation of gene expression. Here we report on the identification of histone H3K56, located at the pivotal, nucleosome DNA entry/exit ...
Pünzeler, Sebastian, Sebastian Pünzeler (381339), Gunnar Schotta (116394), Jack, Antonia P. M., Michael Wells (381341), Bussemer, Silva, Martha Snyder (381340), Hake, Sandra B., Matthias Hahn, Irina Solovei, Solovei, Irina, Hahn, Matthias, Wells, Michael, Gunnar Schotta, Sebastian Pünzeler, Martha Snyder, Sandra B. Hake (165089), Matthias Hahn (209009), Antonia P. M. Jack (381337), Irina Solovei (85), Sandra B Hake, Silva Bussemer, Michael Wells, Antonia P M Jack, Silva Bussemer (381338), Gyorgyi Csankovszki (5654086), Snyder, Martha, Schotta, Gunnar, Csankovszki, Gyorgyi, Gyorgyi Csankovszki   +29 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Functional Analysis of DNA Methylation in Development and Disease [PDF]

, 2006
The genome of mammals harbors chemical modifications at some cytosine residues in the form of a methyl group. These modified residues, termed 5’-methylcytosines, have been discovered more than 50 years ago (Hotchkiss 1948) and have since been shown to ...
Gaudet, François
core  

DNA methylation protects cancer cells against senescence

Nature Communications
Inhibitors of DNA methylation such as 5-aza-deoxycytidine are widely used in experimental and clinical settings. However, their mechanism of action is such that DNA damage inevitably co-occurs with loss of DNA methylation, making it challenging to ...
Xiaoying Chen, Kosuke Yamaguchi, Brianna Rodgers, Delphine Goehrig, David Vindrieux, Xavier Lahaye, Matthieu Nolot, Laure Ferry, Sophie Lanciano, Nadine Martin, Pierre Dubus, Fumihito Miura, Takashi Ito, Gael Cristofari, Nicolas Manel, Masato T. Kanemaki, David Bernard, Pierre-Antoine Defossez   +17 more
doaj   +1 more source

Effects of Selenium on DNA Methylation and Genomic Instability Induced by Drought Stress in Wheat (Triticum aestivum L.)

Türkiye Tarımsal Araştırmalar Dergisi
The main purpose of the study was to clarify the effect of selenium (Se) on DNA damage and DNA methylation in wheat (Triticum aestivum L.) plants exposed to polyethylene glycol (PEG)-induced drought stress under in vitro tissue culture.
Zehra Şahin, Güleray Ağar, Esma Yiğider, Murat Aydın   +3 more
doaj   +1 more source

Total DNA Methylation Changes Reflect Random Oxidative DNA Damage in Gliomas

Cells, 2019
DNA modifications can be used to monitor pathological processes. We have previously shown that estimating the amount of the main DNA epigenetic mark, 5-methylcytosine (m5C), is an efficient and reliable way to diagnose brain tumors, hypertension, and ...
A. Barciszewska, M. Giel-Pietraszuk, Patrick M. Perrigue, M. Naskręt-Barciszewska   +3 more
semanticscholar   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Widespread prevalence of a methylation-dependent switch to activate an essential DNA damage response in bacteria.

PLoS Biology
DNA methylation plays central roles in diverse cellular processes, ranging from error-correction during replication to regulation of bacterial defense mechanisms. Nevertheless, certain aberrant methylation modifications can have lethal consequences.
Aditya Kamat, Ngat T Tran, Mohak Sharda, Neha Sontakke, Tung B K Le, Anjana Badrinarayanan   +5 more
doaj   +1 more source

Oxidative Stress and DNA Methylation in Prostate Cancer

Obstetrics and Gynecology International, 2010
The protective effects of fruits, vegetables, and other foods on prostate cancer may be due to their antioxidant properties. An imbalance in the oxidative stress/antioxidant status is observed in prostate cancer patients.
Krishna Vanaja Donkena, Charles Y. F. Young, Donald J. Tindall   +2 more
doaj   +1 more source

Proanthocyanidins Antagonize Arsenic-Induced Oxidative Damage and Promote Arsenic Methylation through Activation of the Nrf2 Signaling Pathway

Oxidative Medicine and Cellular Longevity, 2019
Purpose To investigate the effects of grape seed proanthocyanidin extract (GSPE) on oxidative damage and arsenic (As) methylation and to clarify the role of Nrf2 in the process.
Mengchuan Xu, Q. Niu, Yunhua Hu, Gangling Feng, Hai-Xia Wang, Shugang Li   +5 more
semanticscholar   +1 more source