Results 91 to 100 of about 2,934,821 (333)

Specific CpG sites methylation is associated with hematotoxicity in low-dose benzene-exposed workers

Environment International
Benzene is a broadly used industrial chemicals which causes various hematologic abnormalities in human. Altered DNA methylation has been proposed as epigenetic biomarkers in health risk evaluation of benzene exposure, yet the role of methylation at ...
Feier Wang, Lizhu Ye, Xinhang Jiang, Rui Zhang, Shen Chen, Liping Chen, Hongyao Yu, Xiaowen Zeng, Daochuan Li, Xiumei Xing, Yongmei Xiao, Wen Chen   +11 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

DataSheet1_Quantitative Analysis of the Protein Methylome Reveals PARP1 Methylation is involved in DNA Damage Response.XLSX

, 2022
Protein methylation plays important roles in DNA damage response. To date, proteome-wide profiling of protein methylation upon DNA damage has been not reported yet.
Xinzhu Wang (1575541), Chenxi Jia (1311606), Yali Chen (24494), Chen Lu (135200), Mingxin Zhao (6838937), Shaojie Mi (12971426)   +5 more
core   +1 more source

Using a medium-throughput comet assay to evaluate the global DNA methylation status of single cells

Frontiers in Genetics, 2014
The comet assay is a simple and cost effective technique, commonly used to analyse and quantify DNA damage in individual cells. The versatility of the comet assay allows introduction of various modifications to the basic technique.
Angelique eLewies, Angelique eLewies, Etresia evan Dyk, Johannes Frederik Wentzel, Johannes Frederik Wentzel, Pieter J Pretorius   +5 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

DataSheet2_Quantitative Analysis of the Protein Methylome Reveals PARP1 Methylation is involved in DNA Damage Response.docx

, 2022
Protein methylation plays important roles in DNA damage response. To date, proteome-wide profiling of protein methylation upon DNA damage has been not reported yet.
Xinzhu Wang (1575541), Chenxi Jia (1311606), Yali Chen (24494), Chen Lu (135200), Mingxin Zhao (6838937), Shaojie Mi (12971426)   +5 more
core   +1 more source

m6A RNA methylation regulates the UV-induced DNA damage response

Nature, 2017
Cell proliferation and survival require the faithful maintenance and propagation of genetic information, which are threatened by the ubiquitous sources of DNA damage present intracellularly and in the external environment.
Yang Xiang, Benoît Laurent, Chih-Hung Hsu, S. Nachtergaele, Zhike Lu, Wanqiang Sheng, Chuanyu Xu, Hao Chen, O. Jian, Siqing Wang, Dominic Ling, Pang-Hung Hsu, Lee Zou, A. Jambhekar, Chuan He, Yang Shi   +15 more
semanticscholar   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Role of histone methylation in paternal transmission of epigenetic information [PDF]

, 2010
During the development of multi-cellular organisms, one genome gives rise to multiple differentiated cell types. This is achieved by sequence specific transcription factors and different epigenetic mechanisms, which collaborate in reading the genetic ...
Brykczynska, Urszula
core   +1 more source

Downregulation of Ambra1 by altered DNA methylation exacerbates dopaminergic neuron damage in a fenpropathrin-induced Parkinson-like mouse model

Ecotoxicology and Environmental Safety
Fenpropathrin (Fen), a volatile pyrethroid insecticide, is used widely for agricultural applications and has been reported to increase the risk of Parkinson’s disease (PD).
Songzhe He, Qi Qu, Xi Chen, Li Zhao, Zhigang Jiao, Zhiting Wan, Hang Fai Kwok, Shaogang Qu   +7 more
doaj   +1 more source