Results 81 to 90 of about 2,934,821 (333)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

DNA demethylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytes

, 2009
Objective: to determine whether changes in the DNA methylation status in the promoter region of the gene encoding interleukin-1? (IL-1?) account for expression of IL1B mRNA after long-term treatment of human articular chondrocytes with inflammatory ...
Hashimoto, Ko, Gibson, Marc B., Helmtrud I. Roach, Mary B. Goldring, Richard O. C. Oreffo, Marc B. Gibson, Oreffo, Richard O.C., Roach, Helmstrud I., Goldring, Mary B., Ko Hashimoto   +9 more
core   +1 more source

DNMTs are required for delayed genome instability caused by radiation [PDF]

, 2012
This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited ...
Anderson, Rhona, Iyer Pooja (7605638), Sandhu, J, Talbot, CJ, Jatinderpal Sandhu (2369116), Narayanan, D, Singh, Rajinder, Tufarelli, Cristina, Anderson, RM, Iyer, P, Deepan Narayanan (7605641), Sandhu, Jatinderpal, Tufarelli, C, Rajinder Singh (246689), Singh, R, George D. Jones (7605635), R. Anderson (3529871), Armstrong, CA, Christopher J. Talbot (7581152), Iyer, Pooja, Jones, GD, C Tufarelli (7605644), Narayanan, Deepan, Christine A. Armstrong (7605632), Armstrong, Christine A., Jones, George Tripp, Talbot, Christopher J.   +26 more
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Transcription influences repair-induced DNA methylation

, 2008
This work is aimed at the dissection of the molecular mechanism(s) linking DNA damage and gene silencing. To this end, we have developed a genetic system that allows a rapid assessment of homologous-directed repair (HR) of an unique DNA double strand ...
Morano, Annalisa
core   +1 more source

Combined Methylation and Transcriptome Analysis of Liver Injury of Nonalcoholic Fatty Liver Disease Induced by High Alcohol-Producing Klebsiella pneumoniae

Microbiology Spectrum, 2023
It has been known that high alcohol-producing Klebsiella pneumoniae (HiAlc Kpn) is one of causative agents of nonalcoholic fatty liver disease (NAFLD). However, how HiAlc Kpn promotes liver injury remains unclear.
Rui Zhang, Ziying Xu, Guanhua Xue, Junxia Feng, Bing Du, Lin Gan, Zheng Fan, Tongtong Fu, Yanling Feng, Hanqing Zhao, Jinghua Cui, Chao Yan, Xiaohu Cui, Ziyan Tian, Jinfeng Chen, Zihui Yu, Jing Yuan   +16 more
doaj   +1 more source

Mechanisms of DNA damage by photoexcited 9-methyl-β-carbolines

Organic & Biomolecular Chemistry, 2013
It has been well documented that β-carboline alkaloids, particularly the 9-methyl derivatives, are efficient photosensitizers. However, structure-activity relationships are missing and the photochemical mechanisms involved in the DNA photodamage still remain unknown.
Vignoni, Mariana, Rasse Suriani, Federico Ariel Osvaldo, Butzbach, Kathrin, Erra Balsells, Rosa, Epe, Bernd, Cabrerizo, Franco Martín   +5 more
openaire   +3 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

A function of thymine DNA glycosylase-initiated DNA repair in maintaining epigenome stability [PDF]

, 2013
The Thymine DNA Glycosylase (TDG) was initially discovered by its ability to excise the deamination products of cytosine and 5-methylcytosine (5-mC), and therefore thought to initiate base excision repair (BER) of the resulting G•U and G•T mismatches.
Jacobs, Angelika L.
core   +1 more source

Image1_Quantitative Analysis of the Protein Methylome Reveals PARP1 Methylation is involved in DNA Damage Response.PDF

, 2022
Protein methylation plays important roles in DNA damage response. To date, proteome-wide profiling of protein methylation upon DNA damage has been not reported yet.
Xinzhu Wang (1575541), Chenxi Jia (1311606), Yali Chen (24494), Chen Lu (135200), Mingxin Zhao (6838937), Shaojie Mi (12971426)   +5 more
core   +1 more source