Results 81 to 90 of about 1,873,698 (292)

Ultraviolet-Induced DNA Damage Promotes RNA m6A Methylation

, 2017
m6A RNA methylation rapidly recruits Pol κ to UV-induced damage sites to facilitate DNA repair.

core   +1 more source

The use of comet assay to assess global DNA methylation in human biomonitoring studies.

Frontiers in Genetics, 2015
The Comet assay is a valuable tool for the detection of DNA damage in genotoxicity and human biomonitoring studies. Throughout the years, this biomarker has undergone several adaptations in their protocol in order to increase its sensitivity and the ...
Carla Costa, Carla Costa, Ana Catarina Alves   +2 more
doaj   +1 more source

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source

New primers for methylation-specific polymerase chain reaction enhance specificity of detecting STAT1 methylation

, 2017
Objective: Signal transducer and activator of transcription (STAT) 1 is a key tumor suppressor, which is always methylated in a variety of human cancers.
Chang, Ming-Cheng;Chiang, Ying-Cheng;Ho, Chih-Ming;Chen, Yu-Li;Chen, Chi-An;Cheng, Wen-Fang;Chou, Cheng-Yang, 鄭文芳;陳祈安;江盈澄   +1 more
core   +1 more source

Reduction in mitochondrial DNA methylation leads to compensatory increase in mitochondrial DNA content: novel blood-borne biomarkers for monitoring occupational noise

Environmental Health and Preventive Medicine
Background: Prolonged occupational noise exposure poses potential health risks, but its impact on mitochondrial DNA (mtDNA) damage and methylation patterns remains unclear.
Jia-Hao Yang, Zhuo-Ran Li, Zhuo-Zhang Tan, Wu-Zhong Liu, Qiang Hou, Pin Sun, Xue-Tao Zhang   +6 more
doaj   +1 more source

DNA methylation and oxidative stress in sleep deprived rats

Sleep Science, 2012
Objective: Sleep deprivation and poor quality of sleep are a current issue in our society. In animal models, sleep deprivation can induce diverse alterations, including oxidative stress in several organs.
Bruno Frederico Aguilar Calegare, Sergio Tufik, Vânia D’Almeida   +2 more
doaj   +1 more source

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source

Race and Household Income Are Associated With Disease Outcomes in Pediatric Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Hospitalized in the United States

Arthritis Care &Research, EarlyView.
Objective Race and household income impact outcomes in patients with rheumatic conditions; however, their role in pediatric antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) remains poorly understood. We aimed to evaluate whether race and ethnicity and household income are associated with severe AAV disease and renal outcomes among
Roberto Alejandro Valdovinos, William Daniel Soulsby III, Emily von Scheven   +2 more
wiley   +1 more source

Chemical Screening Identifies Danofloxacin as a Self‐Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1‐Mediated Deacetylation of Tert and Prdm10

Advanced Science, EarlyView.
This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang, Junxiang Ji, Baoxing Dong, Zhenhua Zhu, Xucheng Lv, Peng Chen, Wenqiang Liu, Min Zhou, Shou‐Dong Ye   +8 more
wiley   +1 more source

Association between DNA methylation of HSPB1 and death in low Gleason score prostate cancer. [PDF]

, 2012
BACKGROUND: Heat shock protein 27 (Hsp-27) encoded by gene HSPB1 is a critical regulator of the behavioral phenotype of human prostate cancer (PCa) cells, enhanced expression being associated with highly aggressive disease and poor clinical outcome.
M A Thorat, Beesley, C, Lorincz, AT, Y-J Lu, H Møller, Y Yu, Cuzick, J, D M Berney, Moller, Henrik; id_orcid, N Vasiljević, Ahmad, A S, C Beesley, Moller, H, J Cuzick, Lu, Y-J, Berney, DM, Foster, C S, Thorat, M A, Vasiljević, N, Ahmad, AS, Fisher, G, Møller, H, Foster, CS, A T Lorincz, Yu, Y, G Fisher, C S Foster, A S Ahmad, Lorincz, A T, Thorat, MA, Berney, D M   +30 more
core   +1 more source