Results 11 to 20 of about 1,647 (123)

Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1). [PDF]

ChemMedChem
DM1 is an RNA gain‐of‐function disease caused by CTG repeat expansion, producing toxic r(CUG)exp RNA that sequesters MBNL1 and impairs splicing. This review covers the field of CUG and CTG ligands identified or rationally designed as DM1 drug candidates, highlighting their molecular design, RNA‐ or DNA‐binding modes, in vitro affinities and ...
Richagneux C, Granzhan A.
europepmc   +2 more sources

Building coiled coils with polar cores. [PDF]

Protein Sci
Abstract Coiled coils are formed by α‐helices winding around each other into superhelical bundles. They are characterized by a specific geometry of interaction, called knobs‐into‐holes, in which residues in the core of the structure mesh regularly along a seam that runs the length of the helices.
Hartmann MD, Alvarez BH, Martinez-Goikoetxea M, Lupas AN.   +3 more
europepmc   +2 more sources

Molecular Adaptations of Thermophilic Proteins-From Mechanistic Understanding to Machine Learning Approaches. [PDF]

ChemistryOpen
Several factors including hydrophobic packing, electrostatic interactions and hydrogen bonding influence thermostability of proteins. Mechanisms of thermal adaptation were investigated via structural and mutational studies. Stability predictions were enhanced by combining thermodynamic data with ML‐based computer models for protein engineering ...
Arunachalam S, Mm B, Gnanasekaran R.
europepmc   +2 more sources

Implications of molecular interactions for protein structure, function and design [PDF]

, 2005
Protein structures are kept in a delicate balance of stability by the interactions of the amino acid residues among themselves, the solvent and other molecules. On one hand they must be stable enough not to unfold, on the other hand they must be mobile
Meier, Markus
core   +1 more source

Full and partial agonists of thromboxane prostanoid receptor unveil fine tuning of receptor superactive conformation and G protein activation. [PDF]

PLoS ONE, 2013
The intrahelical salt bridge between E/D(3.49) and R(3.50) within the E/DRY motif on helix 3 (H3) and the interhelical hydrogen bonding between the E/DRY and residues on H6 are thought to be critical in stabilizing the class A G protein-coupled receptors
Valérie Capra, Marta Busnelli, Alessandro Perenna, Manuela Ambrosio, Maria Rosa Accomazzo, Celine Galés, Bice Chini, G Enrico Rovati   +7 more
doaj   +1 more source

Proteomics Computational Analyses Suggest that the Antennavirus Glycoprotein Complex Includes a Class I Viral Fusion Protein (α-Penetrene) with an Internal Zinc-Binding Domain and a Stable Signal Peptide

Viruses, 2019
A metatranscriptomic study of RNA viruses in cold-blooded vertebrates identified two related viruses from frogfish (Antennarius striatus) that represent a new genus Antennavirus in the family Arenaviridae (Order: Bunyavirales).
Courtney E. Garry, Robert F. Garry
doaj   +1 more source

Structural Insights into the Mechanisms of Action of Short-Peptide HIV-1 Fusion Inhibitors Targeting the Gp41 Pocket

Frontiers in Cellular and Infection Microbiology, 2018
The deep hydrophobic pocket of HIV-1 gp41 has been considered a drug target, but short-peptides targeting this site usually lack potent antiviral activity.
Xiujuan Zhang, Xiujuan Zhang, Yuanmei Zhu, Hao Hu, Senyan Zhang, Pengfei Wang, Huihui Chong, Jinsheng He, Xinquan Wang, Yuxian He   +9 more
doaj   +1 more source

Chemie und Aufbau der Wolle

, 1997
Wool is a fibrous biomaterial with an exceptional multicellular structure and complex chemical composition. This is shown for some selected topics: • Structure of the keratin intermediate filament (KIF) • Expression of keratin IF and keratin-associated ...
Wortmann, Franz Josef, Höcker, H., Wortmann, Franz-Josef, Zahn, Helmut, Höcker, Hartwig   +4 more
core   +6 more sources

Main-chain mutagenesis reveals intrahelical coupling in an ion channel voltage-sensor

Nature Communications, 2018
The helical transmembrane segments of membrane proteins play central roles in sensory transduction but the mechanistic basis for their function remains unresolved.
Daniel T. Infield, Kimberly Matulef, Jason D. Galpin, Kin Lam, Emad Tajkhorshid, Christopher A. Ahern, Francis I. Valiyaveetil   +6 more
doaj   +1 more source

Immunotherapy-induced neutralizing antibodies disrupt allergen binding and sustain allergen tolerance in peanut allergy

The Journal of Clinical Investigation, 2023
In IgE-mediated food allergies, exposure to the allergen activates systemic allergic responses. Oral immunotherapy (OIT) treats food allergies through incremental increases in oral allergen exposure. However, OIT only induces sustained clinical tolerance
Nicole A. LaHood, Jungki Min, Tarun Keswani, Crystal M. Richardson, Kwasi Amoako, Jingjia Zhou, Orlee Marini-Rapoport, Hervé Bernard, Stéphane Hazebrouck, Wayne G. Shreffler, J. Christopher Love, Anna Pomes, Lars C. Pedersen, Geoffrey A. Mueller, Sarita U. Patil   +14 more
doaj   +1 more source