Results 21 to 30 of about 1,647 (123)

Structural and functional consequences of the Milano mutation (R173C) in human apolipoprotein A-I

Journal of Lipid Research, 2009
Carriers of the apolipoprotein A-IMilano (apoA-IM) variant, R173C, have reduced levels of plasma HDL but no increase in cardiovascular disease. Despite intensive study, it is not clear whether the removal of the arginine or the introduction of the ...
Eric T. Alexander, Masafumi Tanaka, Momoe Kono, Hiroyuki Saito, Daniel J. Rader, Michael C. Phillips   +5 more
doaj   +1 more source

Sequence-dependent Structural Variation in DNA Undergoing Intrahelical Inspection by the DNA glycosylase MutM

, 2019
MutM, a bacterial DNA-glycosylase, plays a critical role in maintaining genome integrity by catalyzing glycosidic bond cleavage of 8-oxoguanine (oxoG) lesions to initiate base excision DNA repair.
Sung, Rou-Jia, Zhang, Michael, Qi, Yan, Verdine, Gregory   +3 more
core   +1 more source

The Mutagenic Damaged DNA Base, 5,6-Dihydrouracil (DHU), Incorporated into a 14-mer Duplex:  NMR Evidence That DHU Is Intrahelical and Causes Minimal DNA Distortion

, 2016
The Mutagenic Damaged DNA Base, 5,6-Dihydrouracil (DHU), Incorporated into a 14-mer Duplex:  NMR Evidence That DHU Is Intrahelical and Causes Minimal DNA ...
Luigi G. Marzilli (1599514), Jan Pohl (177453), Julie M. Villanueva (463962), Paul W. Doetsch (487148)   +3 more
core   +1 more source

Conserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors

Viruses, 2019
Entry of HIV-1 into target cells is mediated by its envelope (Env) glycoprotein composed of the receptor binding subunit gp120 and the fusion protein gp41. Refolding of the gp41 N- and C-terminal heptad repeats (NHR and CHR) into a six-helix bundle (6-HB)
Xiuzhu Geng, Zixuan Liu, Danwei Yu, Bo Qin, Yuanmei Zhu, Sheng Cui, Huihui Chong, Yuxian He   +7 more
doaj   +1 more source

The CD-loop of PAI-2 (SERPINB2) is redundant in the targeting, inhibition and clearance of cell surface uPA activity

BMC Biotechnology, 2009
Background Plasminogen activator inhibitor type-2 (PAI-2, SERPINB2) is an irreversible, specific inhibitor of the urokinase plasminogen activator (uPA). Since overexpression of uPA at the surface of cancer cells is linked to malignancy, targeting of uPA ...
Vine Kara L, Gunawardhana Lakshitha P, Cochran Blake J, Lee Jodi A, Lobov Sergei, Ranson Marie   +5 more
doaj   +1 more source

Base-flipping dynamics from an intrahelical to an extrahelical state exerted by thymine DNA glycosylase during DNA repair process [PDF]

, 2018
Thymine DNA glycosylase (TDG) is a DNA repair enzyme that excises a variety of mismatched or damaged nucleotides (nts), e.g. dU, dT, 5fC and 5caC. TDG is shown to play essential roles in maintaining genome integrity and correctly programming epigenetic ...
Yu, Jin, Da, Lin-Tai, Lin-Tai Da, Jin Yu
core   +1 more source

Effects of polymorphism on the microenvironment of the LDL receptor-binding region of human apoE

Journal of Lipid Research, 2001
To understand the molecular basis for the differences in receptor-binding activity of the three common human apolipoprotein E (apoE) isoforms, we characterized the microenvironments of their LDL receptor (LDLR)-binding regions (residues 136–150).
Sissel Lund-Katz, Suzanne Wehrli, Mohamed Zaiou, Yvonne Newhouse, Karl H. Weisgraber, Michael C. Phillips   +5 more
doaj   +1 more source

Interaction with NEGR1 affects mGlu5 cell signalling and the neuroprotection induced by the positive allosteric modulator VU0409551

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The metabotropic glutamate receptor mGlu5 plays an important role in neuronal survival and synaptic plasticity. We and others have shown that mGlu5 positive allosteric modulators (PAMs) are biased agonists, triggering the activation of neuroprotective pathways and promoting neuronal survival. As mGlu5 biased pharmacology
Jennifer D. S. Guimaraes, Toniana G. Carvalho, Luan A. Pereira, Emanuele G. Silva, Esther M. A. Maciel, Gabriella P. Torres, Thiago Assis, Pablo L. Cardozo, Joao P. P. de Almeida, Nathalia C. Silva, Francesca Pischedda, Giovanni Piccoli, Luciene B. Vieira, Juliana Alves‐Silva, Fabiola M. Ribeiro   +14 more
wiley   +1 more source

Evidence for a Two‐Step Model for Activation of GPR25 by the Chemoattractant CXCL17

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 1, July 2026.
ABSTRACT CXCL17 was recently reported to activate GPR25, a receptor expressed by T‐regulatory cells. Although classified as a chemokine, the activity of CXCL17 is ablated by minor C‐terminal truncation, suggesting a novel mode of receptor activation. We set out to test this hypothesis by mutagenesis. GPR25 was expressed in the murine pre‐B cell line L1.
Wuqing Yang, Sean P. Giblin, James E. Pease   +2 more
wiley   +1 more source

From transporter to motor: Evolutionary and structural insights into the emergence of prestin's area‐motor activity in mammals

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Prestin, a member of the SLC26A family, is essential for the electromotility of mammalian outer hair cells, converting voltage changes into mechanical work. In contrast, nonmammalian orthologues function as anion transporters. To investigate the molecular and structural basis of this functional divergence, we performed ancestral sequence ...
Nicolás Fuentes‐Ugarte, Tiaren Ruiz‐Rojas, Felipe Garcia‐Olave, Alvaro Ruiz‐Fernandez, Jose Antonio Garate, Victor Castro‐Fernandez, Raul Araya‐Secchi   +6 more
wiley   +1 more source