Results 171 to 180 of about 158,534 (314)

The Photophysics of Nucleic Acids: Consequences for the Emergence of Life

ChemSystemsChem, Volume 5, Issue 1, January 2023., 2023
Photochemical reactions in nucleic acids induced by ultraviolet (UV) radiation could have played an important role in the prebiotic selection of the building blocks of life. This Review summarizes the quantum efficiencies of the photorelaxation pathways of nucleic acids and discusses its implications for the emergence of an initial sequence pool on ...
Corinna L. Kufner, Dominik B. Bucher, Dimitar D. Sasselov   +2 more
wiley   +1 more source

Skeletal Muscle Memory: An Update From the Antidoping Perspective

Drug Testing and Analysis, EarlyView.
ABSTRACT This narrative review explores the concept of muscle memory, focusing on the physiological and biochemical mechanisms underlying information retention in skeletal muscle tissue as it relates to antidoping. The discussion encompasses the role of satellite cells (SCs) in myonuclei recruitment, resulting in increased myonuclear density and ...
Claire Traversa
wiley   +1 more source

RNA Oligomerisation without Added Catalyst from 2′,3′‐Cyclic Nucleotides by Drying at Air‐Water Interfaces**

ChemSystemsChem, Volume 5, Issue 1, January 2023., 2023
Without catalyst! A non‐enzymatic, spontaneous route to the formation of short, mixed‐sequence RNA strands from 2′,3′‐cyclic ribonucleotides is shown. The reaction occurs by drying at the air–water interfaces. Abstract For the emergence of life, the abiotic synthesis of RNA from its monomers is a central step.
Avinash Vicholous Dass, Sreekar Wunnava, Juliette Langlais, Beatriz von der Esch, Maik Krusche, Lennard Ufer, Nico Chrisam, Romeo C. A. Dubini, Florian Gartner, Severin Angerpointner, Christina F. Dirscherl, Petra Rovó, Christof B. Mast, Judit E. Šponer, Christian Ochsenfeld, Erwin Frey, Dieter Braun   +16 more
wiley   +1 more source

Thymoquinone induces apoptosis in temozolomide‐resistant glioblastoma cells via the p38 mitogen‐activated protein kinase signaling pathway

Environmental Toxicology, Volume 38, Issue 1, Page 90-100, January 2023., 2023
Abstract Temozolomide (TMZ) can cross the blood‐brain barrier (BBB) and deliver methyl groups to the purine (guanine) bases of DNA, leading to mispairing during DNA replication and subsequent cell death. However, increased expression of the repair enzyme methyl guanine methyltransferase (MGMT), which removes methyl groups from purine bases, counteracts
Ai Mai, Shu‐Wen Ye, Jia‐Yu Tu, Jun Gao, Zhan‐Fang Kang, Qian‐Ming Yao, Wei‐Jen Ting   +6 more
wiley   +1 more source

The Role of Guanine Nucleotides in the Interaction between Aminoacyl-tRNA and Elongation Factor 1 of Artemia salina [PDF]

, 1978
Kees Roobol, W. Möller
openalex   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Elastic Nanoparticle‐Reinforced, Conductive Structural Color Hydrogel With Super Stretchability, Self‐Adhesion, Self‐Healing as Electrical/Optical Dual‐Responsive Visual Electronic Skins

Exploration, EarlyView.
A conductive structural color hydrogel with highly charged elastic nanoparticles was developed by implementing a simple one‐step assembly and photopolymerization strategy that can achieve excellent mechanical robustness, self‐adhesiveness, self‐healing properties, as well as synchronous electronic and visual signal monitoring for interactively visual ...
Min Xu, Junlong Liao, Jiajia Li, Yu Shi, Ziyu Zhang, Yifu Fu, Zhongze Gu, Hua Xu   +7 more
wiley   +1 more source

Measuring the tail: Methods for poly(A) tail profiling

WIREs RNA, Volume 14, Issue 1, January/February 2023., 2023
A development of the methods used to study the length and composition of poly(A) tails, uncovering the 3′‐end tailing as a much more complex and impactful process than previously thought. Abstract The 3′‐end poly(A) tail is an important and potent feature of most mRNA molecules that affects mRNA fate and translation efficiency.
Aleksandra Brouze, Paweł Szczepan Krawczyk, Andrzej Dziembowski, Seweryn Mroczek   +3 more
wiley   +1 more source

Asymmetric Distribution of Guanine Plus Thymine Between Complementary Strands of Deoxyribonucleic Acid of Members of the Enterobacteriaceae [PDF]

, 1971
Charles L. Hershberger, Stuart J. Mickel, R H Rownd   +2 more
openalex   +1 more source