Results 171 to 180 of about 316,659 (284)

Acyclic Nucleoside Phosphonates As Potential Inhibitors Of Plasmodium Falciparum Egress

Chemistry – A European Journal, EarlyView.
Exploration of the chemistry of acyclic nucleoside phosphonates allowed us to study structural diversity from the hit compound; biological evaluation and molecular docking were performed to decipher key interactions with the putative target. Abstract The emergence of drug‐resistant Plasmodium strains requires the development of novel antimalarial ...
Thomas Cheviet, Sharon Wein, Corinne Lionne, Yan Badji, Natacha Venturini, Rachel Cerdan, Suzanne Peyrottes   +6 more
wiley   +1 more source

Development of Synthetic Routes to 2′‐O,4′‐C‐Spirocyclopentylene‐Bridged Nucleic Acids: Thymidine, Guanosine, and Adenosine

Chemistry – A European Journal, EarlyView.
A novel synthetic route to 2′‐O,4′‐C‐spirocyclopentylene‐bridged nucleic acid (scpBNA2) monomers bearing thymine, guanine, and adenine nucleobases. The strategy integrates 2′,4′‐lactonization, transglycosylation, and intramolecular iodocyclization, thereby bypassing the 2′‐OH inversion step and providing scpBNA2 nucleoside building blocks for antisense
Riku Kumagai, Riko Yamada, Takao Yamaguchi, Satoshi Obika   +3 more
wiley   +1 more source

Electrocatalytic activity of oxidation products of guanine and 5′-GMP towards the oxidation of NADH

, 2007
Noemí de‐los‐Santos‐Álvarez, María Jesús Lobo‐Castañón, Arturo J. Miranda‐Ordieres, Paulino Tuñón‐Blanco   +3 more
openalex   +2 more sources

Convergent Synthesis of Template‐Assembled Synthetic G‐Quartets (TASQs) Used as Biomimetic and Multivalent G‐Quadruplex (G4) Ligands

Chemistry – A European Journal, EarlyView.
The family of template‐assembled synthetic G‐quartets, or TASQs, comprises different molecular tools that have been successfully used to decipher G‐quadruplex (G4) biology (via optical imaging and/or affinity precipitation). The synthetic access to the different TASQs has been thoroughly revisited herein to make it simpler and more efficient thanks to ...
Sandy Raevens, Cécile Desingle, Marc Pirrotta, Francesco Rota Sperti, Andréa Pieri, Pauline Lejault, Ibai E. Valverde, David Monchaud   +7 more
wiley   +1 more source

Ligand specificity and adaptability revealed by the first Guanine-II riboswitch tertiary structure. [PDF]

Nucleic Acids Res
Li H, Shen X, Xu X, Tai X, He M, Zhang J, Ren A.   +6 more
europepmc   +1 more source

Enhancing G‐Quadruplex Binding: Rational Design and Biophysical Evaluation of Dimeric Ligands

Chemistry – A European Journal, EarlyView.
Fluorescence thermal shift assays, electrospray ionization‐mass spectrometry, CD spectroscopy, molecular modeling and cytotoxicity assays were enrolled to study the binding of a rationally designed anthraquinone‐based G‐quadruplex binder interacting with the nucleic acid as a molecular tweezer.
Matteo Giannangeli, Nicolò Dal Ponte, Margrate Anyanwu, Martina Brigida Romanello, Ernesto Mucenji, Riccardo Rigo, Giovanni Ribaudo, Claudia Sissi, Alessandra Gianoncelli   +8 more
wiley   +1 more source

Crystallization and crystallographic analysis of yeast Sec2p, a guanine nucleotide-exchange factor for the yeast Rab GTPase Sec4p [PDF]

, 2007
Yusuke Sato, Shuya Fukai, Osamu Nureki
openalex   +1 more source

Supplementary Video 4 from Iodide Transporter NIS Regulates Cancer Cell Motility and Invasiveness by Interacting with the Rho Guanine Nucleotide Exchange Factor LARG

, 2023
Claire Lacoste, Julie Hervé, Myriam Bou Nader, Alexandre dos Santos, Nicolas Moniaux, Yannick Valogne, Rodrick Montjean, Olivier Dorseuil, Didier Samuel, Doris Cassio, Carla Portulano, Nancy Carrasco, Christian Bréchot, J Faivre   +13 more
openalex   +1 more source

ARC Expands the DAAM1 Microexon‐Mediated Actin–RHOA/ROCK Interplay

Cytoskeleton, EarlyView.
ABSTRACT Actin cytoskeleton and its dynamics play a crucial role in synaptic function, influencing dendritic spines' structural and functional plasticity. Recent findings unveiled the significance of alternative splicing of a neural‐specific microexon in DAAM1 in modulating actin's role in synaptic processes.
Patryk Poliński, Marta Miret Cuesta, Manuel Irimia   +2 more
wiley   +1 more source

Solid-Phase Synthesis of Guanine Derivatives with Four Diversity Elements via AgNO₃‑Mediated Guanidine Formation. [PDF]

ACS Omega
Moon J, Lee J, Lee H, Yoon G, Lee T.
europepmc   +1 more source