Results 191 to 200 of about 38,557 (248)
Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
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Cardiotoxicity of BRAF/MEK inhibitors
British Journal of Pharmacology, EarlyView.Abstract Rapidly accelerated fibrosarcoma type B/B‐Raf proto‐oncogene, serine/threonine kinase (BRAF) and mitogen‐activated protein kinase (MEK) inhibitors have transformed outcomes in cancer therapy, particularly in melanoma. However, cardiovascular toxicities are increasingly recognized in real‐world clinical practice.
Katharina Seuthe +4 more
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Biogenic Guanine Crystals Are Solid Solutions of Guanine and Other Purine Metabolites [PDF]
Journal of the American Chemical Society, 2022 Highly reflective crystals of the nucleotide base guanine are widely distributed in animal coloration and visual systems. Organisms precisely control the morphology and organization of the crystals to optimize different optical effects, but little is ...
Gil Goobes, Kenneth Harris, Gan Zhang
exaly +8 more sources
Guanine-vacancy–bearing G-quadruplexes responsive to guanine derivatives [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2015 Significance Guanine-rich nucleic acids fold into a four-stranded structure named G-quadruplex that has implications in essential cellular processes, pharmaceutical applications, and nanodevices. We found a unique type of G-quadruplex that contains a G-vacancy and is stabilized by guanine derivatives such as te physiological ...
Bi-feng Yuan, Honghe Liu, Zheng Tan
exaly +3 more sources
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Bioinspired Crystallization of Guanine
The Journal of Physical Chemistry Letters, 2021Biological guanine crystals in organisms exhibit excellent optical properties and functions, including broad-band and narrow-band reflectors, band-tunable reflectors, mirrors, and stimuli-responsive structural colors, attributed to the high refractive index of guanine (1.85) and the exquisite control of the polymorphs, morphologies, sizes, exposed ...
Fenghua Chen +3 more
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Microhydration of the Guanine−Guanine and Guanine−Cytosine Base Pairs
The Journal of Physical Chemistry A, 2010Monohydration structures of the guanine-guanine and guanine-cytosine base pairs have been elucidated by IR-UV double resonance spectroscopy combined with ab initio calculations. The systems studied consist of the homodimer of 9-methylguanine and the heterodimer of 9-methylguanine and 1-methylcytosine in which the methyl group is introduced to mimic the
Shu-Hei, Urashima +3 more
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Conserved guanine-guanine stacking in tetraplex and duplex DNA
European Biophysics Journal, 2001Using a series of suitably chosen oligonucleotides, we demonstrate that the DNA duplex of d(CCCCGGGG) provides an almost identical CD spectrum as the parallel-stranded tetraplex of d(GGGG). The CD spectra are very sensitive to base stacking in DNA so that the above observation indicates that guanine-guanine stacking is essentially the same within the ...
J, Kypr +4 more
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Metabolism of Guanine and Guanine Nucleotides in Primary Rat Cardiomyocyte Cultures
Biochemical and Molecular Medicine, 1995The metabolic fate of labeled guanine and of prelabeled guanine nucleotides (GuRN) was studied in cultured rat cardiomyocytes. Special attention was given to guanine salvage in comparison to degradation; to the contribution of GuRN to adenine nucleotides (AdRN); to the fluxes from GMP to IMP and from IMP to GMP; and to the degradation pathways of GuRN.
E, Zoref-Shani +4 more
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Metabolism of Guanine and Guanine Nucleotides in Primary Rat Neuronal Cultures
Journal of Neurochemistry, 1992Abstract: The metabolic fate of guanine and of guanine ribonucleotides (GuRNs) in cultured rat neurons was studied using labeled guanine. 8‐Aminoguanosine (8‐AGuo), an inhibitor of purine nucleoside phosphorylase, was used to clarify the pathways of GMP degradation, and mycophenolic acid, an inhibitor of IMP dehydrogenase, was used to assess the flux ...
S, Brosh +3 more
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Improved selectivity for the binding of naphthyridine dimer to guanine–guanine mismatch
Bioorganic & Medicinal Chemistry, 2001Naphthyridine dimer composed of two 2-amino-1,8-naphthyridines and a connecting linker strongly binds to guanine-guanine (G-G) mismatch in duplex DNA. In order to improve G-G selectivity for the binding, we have examined structure modification of the linker.
Nakatani, K, Sando, S, Saito, I
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