Results 81 to 90 of about 158,534 (314)

The intermolecular dimer potential for guanine

The Journal of Chemical Physics, 2017
The ab initio intermolecular potential of guanine has been developed with the help of a combination of symmetry-adapted perturbation theory and density functional theory (DFT). The resulting potential has been globally optimized to locate the guanine cluster structures up to tetramers.
Artür Manukyan, Adem Tekin
openaire   +4 more sources

PNA Functionalized Gold Nanoparticles on TiO2 Nanotubes Biosensor for Electrochemical DNA Fragment Detection

Advanced Materials Interfaces, EarlyView.
This experiment investigates the development of a highly sensitive biosensor platform incorporating AuNPs with TiO2‐NTs as electrode materials. Robust PNA probes and an optimized hybridization protocol are employed to enhance performance. An appropriate level of AuNPs on the surface effectively prevents non‐specific binding of target DNA fragments ...
Younghwan Kim, Swomitra Kumar Mohanty
wiley   +1 more source

Inverse Virtual Screening, Recombinant Expression, and Activity Characterization of Purine Degrading Enzymes

Shipin gongye ke-ji
To develop a novel purine degrading enzyme that can be used in the food industry, this study aimed to screen an enzyme with potential purine degradation activity using inverse virtual screening technology and molecular docking technology, clone express ...
Yu LIU, Xinxin ZHANG, Rui WANG, Xianghong MENG   +3 more
doaj   +1 more source

Structural Insights into an Antiparallel Chair‐Type G‐Quadruplex From the Intron of NOP56 Oncogene

Advanced Science, EarlyView.
This study first reports that the intron 1 of NOP56 oncogene forms an antiparallel chair‐type G4 structure composed of two G‐tetrads and one C∙G∙C∙G tetrad. NOP56 gene transcription can be inhibited by PDS that binds and stabilizes NOP56‐G4. Solution NMR structures of the free NOP56‐G4 and NOP56‐G4‐PDS complex provide valuable insights into G4 ...
Zhenzhen Yan, Axin He, Liqi Wan, Qian Gao, Yan Jiang, Yang Wang, Ercheng Wang, Changling Li, Yingquan Yang, Yingjie Li, Pei Guo, Da Han   +11 more
wiley   +1 more source

A DNP‐Supported Solid‐State NMR Approach to Study Nucleic Acids In Situ Reveals Berberine‐Stabilized Hoogsteen Structures in Mitochondria

Angewandte Chemie, EarlyView.
Mitochondria are vital for energy production and rely on intricate nucleic acid structures to regulate gene expression. Using DNP‐ssNMR (dynamic nuclear polarization solid‐state NMR), we observed G‐quadruplex formation in intact mitochondria treated with berberine.
Michaela Dzurov Krafčíková, David Beriashvili, Salima Bahri, Menno Bergmeijer, Stuart C. Howes, Andrei Gurinov, Friedrich G. Förster, Gert E. Folkers, Marc Baldus   +8 more
wiley   +2 more sources

Spin transport and polarization properties of manganese-doped dual-guanine molecule [PDF]

arXiv, 2014
We study the spin transport and polarization properties of manganese-doped dual-guanine molecules connected to graphene leads using non-equilibrium Green's function method. It is shown that a manganese doped dual-guanine molecule is a biological semiconductor and behaves as a prefect spin filter.
arxiv  

Global deformation facilitates flipping of damaged 8-oxo-guanine and guanine in DNA [PDF]

Nucleic Acids Research, 2016
Oxidation of guanine (Gua) to form 7,8-dihydro-8-oxoguanine (8oxoG) is a frequent mutagenic DNA lesion. DNA repair glycosylases such as the bacterial MutM can effciently recognize and eliminate the 8oxoG damage by base excision. The base excision requires a 8oxoG looping out (flipping) from an intrahelical base paired to an extrahelical state where the
Martin Zacharias, Giuseppe La Rosa
openaire   +4 more sources

High‐Viability Circulating Tumor Cells Sorting From Whole Blood at Single Cell Level Using Laser‐Induced Forward Transfer‐Assisted Microfiltration

Advanced Science, EarlyView.
A laser‐induced forward transfer‐assisted microfiltration system is developed for single rare cell sorting from undiluted whole blood. The isolated cell has a high viability, enabling successful ex vivo cell culture and efficient single‐cell RNA sequencing.
Qingmei Xu, Yuntong Wang, Songtao Dou, Yang Xu, Zhenhe Xu, Han Xu, Yi Zhang, Yanming Xia, Ying Xue, Hang Li, Xiao Ma, Kunlong Zhang, Huan Wang, Fengzhou Ma, Qi Wang, Bei Li, Wei Wang   +16 more
wiley   +1 more source

A Method for Constructing Nucleosome Arrays with Spatially Defined Histone PTMs and DNA Damage

Angewandte Chemie, EarlyView.
This work advances methodology by addressing challenges in mimicking the complex in vivo spatial relationships of histone acetylation and DNA damage. The combination of an abiotic/enzymatic hybrid catalyst system (ABEHCS) and the plug‐and‐play method has constituted a versatile platform to construct nucleosome arrays with precise histone acetylation ...
Ziyun Liu, Siqi Xi, Lauren A. McGregor, Kenzo Yamatsugu, Shigehiro A. Kawashima, Jonathan T. Sczepanski, Motomu Kanai   +6 more
wiley   +2 more sources

High‐Speed Hyperspectral Imaging for Near Infrared Fluorescence and Environmental Monitoring

Advanced Science, EarlyView.
This study introduces a fast hyperspectral imaging method in the near‐infrared range (HyperNIR). Combining tunable polarization optics with a phasor‐based approach, HyperNIR captures detailed spectral information with just three images. The applicability is showcased by distinguishing NIR fluorophores that are separated by 5 nm.
Jan Stegemann, Franziska Gröniger, Krisztian Neutsch, Han Li, Benjamin Scott Flavel, Justus Tom Metternich, Luise Erpenbeck, Poul Bering Petersen, Per Niklas Hedde, Sebastian Kruss   +9 more
wiley   +1 more source