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Metabolism of Guanine and Guanine Nucleotides in Primary Rat Neuronal Cultures
Journal of Neurochemistry, 1992Abstract: The metabolic fate of guanine and of guanine ribonucleotides (GuRNs) in cultured rat neurons was studied using labeled guanine. 8‐Aminoguanosine (8‐AGuo), an inhibitor of purine nucleoside phosphorylase, was used to clarify the pathways of GMP degradation, and mycophenolic acid, an inhibitor of IMP dehydrogenase, was used to assess the flux ...
Yechezkel Sidi, O Sperling, S Brosh
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Bioinspired Crystallization of Guanine
The Journal of Physical Chemistry Letters, 2021Biological guanine crystals in organisms exhibit excellent optical properties and functions, including broad-band and narrow-band reflectors, band-tunable reflectors, mirrors, and stimuli-responsive structural colors, attributed to the high refractive index of guanine (1.85) and the exquisite control of the polymorphs, morphologies, sizes, exposed ...
Fenghua Chen +3 more
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Microhydration of the Guanine−Guanine and Guanine−Cytosine Base Pairs
The Journal of Physical Chemistry A, 2010Monohydration structures of the guanine-guanine and guanine-cytosine base pairs have been elucidated by IR-UV double resonance spectroscopy combined with ab initio calculations. The systems studied consist of the homodimer of 9-methylguanine and the heterodimer of 9-methylguanine and 1-methylcytosine in which the methyl group is introduced to mimic the
Shu-Hei, Urashima +3 more
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Conserved guanine-guanine stacking in tetraplex and duplex DNA
European Biophysics Journal, 2001Using a series of suitably chosen oligonucleotides, we demonstrate that the DNA duplex of d(CCCCGGGG) provides an almost identical CD spectrum as the parallel-stranded tetraplex of d(GGGG). The CD spectra are very sensitive to base stacking in DNA so that the above observation indicates that guanine-guanine stacking is essentially the same within the ...
J, Kypr +4 more
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Improved selectivity for the binding of naphthyridine dimer to guanine–guanine mismatch
Bioorganic & Medicinal Chemistry, 2001Naphthyridine dimer composed of two 2-amino-1,8-naphthyridines and a connecting linker strongly binds to guanine-guanine (G-G) mismatch in duplex DNA. In order to improve G-G selectivity for the binding, we have examined structure modification of the linker.
Nakatani, K, Sando, S, Saito, I
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Metabolism of Guanine and Guanine Nucleotides in Primary Rat Cardiomyocyte Cultures
Biochemical and Molecular Medicine, 1995The metabolic fate of labeled guanine and of prelabeled guanine nucleotides (GuRN) was studied in cultured rat cardiomyocytes. Special attention was given to guanine salvage in comparison to degradation; to the contribution of GuRN to adenine nucleotides (AdRN); to the fluxes from GMP to IMP and from IMP to GMP; and to the degradation pathways of GuRN.
E, Zoref-Shani +4 more
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Guanine Uptake by Human Erythrocytes
1991It has been clearly established that mature human erythrocytes cannot synthesize de novo purines (1); consequently the turnover of purine nucleotides in red cells must result from the continual entry and release of purines. Hypoxanthine and adenine uptake by human erythrocytes has been studied in our laboratories (2–4).
SPOTO, Giuseppe +2 more
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Photodynamic degradation of guanine
Biochemical and Biophysical Research Communications, 1964J S, Sussenbach, W, Berends
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