Results 41 to 50 of about 191,107 (300)

Simultaneous Determination of Four DNA bases at Graphene Oxide/Multi-Walled Carbon Nanotube Nanocomposite-Modified Electrode

Micromachines, 2020
In this study, we developed a modified glassy carbon electrode (GCE) with graphene oxide, multi-walled carbon nanotube hybrid nanocomposite in chitosan (GCE/GO-MWCNT-CHT) to achieve simultaneous detection of four nucleobases (i.e., guanine (G), adenine ...
Shuting Wang, Celia Ferrag, Meissam Noroozifar, Kagan Kerman   +3 more
doaj   +1 more source

Selective Functionalization at N2-Position of Guanine in Oligonucleotides via Reductive Amination

, 2020
Chemo- and site-specific modifications in oligonucleotides have wide applicability as mechanistic probes in chemical biology. Here we have employed a classical reaction in organic chemistry, reductive amination, to selectively functionalize the N2-amine ...
Bapurao, Bhoge, Ishu, Saraogi
core   +1 more source

Guanine crystals discovered in bacteria [PDF]

, 2022
Guanine crystals are organic biogenic crystals found in many organisms. Due to their exceptionally high refractive index, they contribute to structural color and are responsible for the reflective effect in the skin and visual organs in animals such as ...
Pavan, María Elisa, Pavan, Esteban E., Movilla, Federico, Pettinari, María Julia, López, Nancy Beatriz, Di Salvo, Florencia   +5 more
core   +1 more source

Molecular dynamics simulation study of the binding of purine bases to the aptamer domain of the guanine sensing riboswitch

, 2009
Riboswitches are a novel class of genetic control elements that function through the direct interaction of small metabolite molecules with structured RNA elements.
Stock, Gerhard, Wöhnert, Jens, Villa, Alessandra, Wohnert, J., Villa, A.   +4 more
core   +1 more source

Interplay of 'induced fit' and preorganization in the ligand induced folding of the aptamer domain of the guanine binding riboswitch

, 2006
Riboswitches are highly structured elements in the 50-untranslated regions (50-UTRs) of messenger RNA that control gene expression by specifically binding to small metabolite molecules. They consist of an aptamer domain responsible for ligand binding and
Wöhnert, Jens, Nasiri, Hamid Reza, Fürtig, Boris, Buck, Janina, Schwalbe, Harald (Prof. Dr.), Noeske, Jonas   +5 more
core   +1 more source

Dissecting the influence of Mg2+ on 3D architecture and ligand-binding of the guanine-sensing riboswitch aptamer domain

, 2010
Long-range tertiary interactions determine the three-dimensional structure of a number of metabolite-binding riboswitch RNA elements and were found to be important for their regulatory function. For the guanine-sensing riboswitch of the Bacillus subtilis
Wöhnert, Jens, Buck, Janina, Schwalbe, Harald (Prof. Dr.), Noeske, Jonas   +3 more
core   +1 more source

A cytohesin homolog in Dictyostelium amoebae. [PDF]

, 2010
Dictyostelium, an amoeboid motile cell, harbors several paralogous Sec7 genes that encode members of three distinct subfamilies of the Sec7 superfamily of Guanine nucleotide exchange factors.
Kolanus, Waldemar, Müller, Rolf, Rosemarie Blau-Wasser, Blau-Wasser, Rosemarie, Glöckner, Gernot, Angelika A Noegel, Noegel, Angelika A., Gernot Glöckner, Rolf Müller, Michael Schleicher, Eichinger, Ludwig, Schleicher, Michael, Maria Christina Shina, Waldemar Kolanus, Ludwig Eichinger, Shina, Maria Christina   +15 more
core   +1 more source

Identification of a guanine-specific pocket in the protein N of SARS-CoV-2

, 2022
The SARS-CoV-2 nucleocapsid protein (N) is responsible for RNA binding. Here we report the crystal structure of the C-terminal domain (N(CTD)) in open and closed conformations and in complex with guanine triphosphate, GTP.
Rafael Ciges-Tomas, J., J. Rafael Ciges-Tomas, Franco, María Luisa, Marçal Vilar, Vilar, Marçal, María Luisa Franco, Ciges-Tomas, J. Rafael   +6 more
core   +1 more source

Influence of ground-state structure and Mg2+ binding on folding kinetics of the guanine-sensing riboswitch aptamer domain

, 2011
Riboswitch RNAs fold into complex tertiary structures upon binding to their cognate ligand. Ligand recognition is accomplished by key residues in the binding pocket.
Julia Wirmer-Bartoschek, Anna Wacker, Wirmer-Bartoschek, J., Schwalbe, H., Wacker, A., Wirmer-Bartoschek, Julia, Eberhart Warkentin, Buck, Janina, Warkentin, E., Wacker, Anna, Wöhnert, Jens, Schwalbe, Harald, Harald Schwalbe, Wöhnert, J., Jens Wöhnert, Warkentin, Eberhart, Buck, J., Janina Buck   +17 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source