Results 51 to 60 of about 191,107 (300)

Rational Design and Structure Validation of a Novel Peptide Inhibitor of the Adenomatous-Polyposis-Coli (APC)–Rho-Guanine-Nucleotide-Exchange-Factor‑4 (Asef) Interaction

, 2018
In colorectal cancer, adenomatous polyposis coli (APC) interacts with Rho guanine-nucleotide-exchange factor 4 (Asef), thereby stimulating aberrant colorectal-cancer-cell migration.
Kun Song (522456), Jianrong Xu (297099), Jie Zhong (39213), Xiuyan Yang (174235), Ke Ding (309244), Cong Ruan (5643581), Jinxing Qian (5643578), Qiufen Zhang (2578927), Jian Zhang (1682)   +8 more
core   +3 more sources

Eco-Friendly Synthesis of Nitrogen-Doped Mesoporous Carbon for Supercapacitor Application

C, 2018
A sustainable and simple synthesis procedure involving the co-assembly of green phenolic resin and amphiphilic polymer template in water/ethanol mixture at room temperature to synthesize nitrogen doped mesoporous carbon is reported herein.
Georges Moussa, Samar Hajjar-Garreau, Pierre-Louis Taberna, Patrice Simon, Camélia Matei Ghimbeu   +4 more
doaj   +1 more source

Concurrent use of rabacfosadine and L‐asparaginase for relapsed or refractory multicentric lymphoma in dogs

Journal of Veterinary Internal Medicine, 2020
Background Rabacfosadine (RAB), a novel antineoplastic agent conditionally licensed for the treatment of lymphoma in dogs, is efficacious in both naïve and previously treated dogs.
Jacob R. Cawley, Zachary M. Wright, Karri Meleo, Gerald S. Post, Craig A. Clifford, Kathryn R. Vickery, David M. Vail, Philip J. Bergman, Douglas H. Thamm   +8 more
doaj   +1 more source

Reduction-Responsive DNA Duplex Containing O⁶‑Nitrobenzyl-Guanine

, 2018
Stimuli-controlled structural transitions of nucleic acids have received growing attentions owing to their potential applications in the fields of chemical and synthetic biology.
Aya Shibata (1907263), Masato Ikeda (2222884), Yukio Kitade (283049), Yukiko Hayakawa (5638874), Hiroaki Kitagawa (2057113), Ayaka Banno (5638877), Sayuri Higashi (5638880)   +6 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Uncovering the Signaling Pathway behind Extracellular Guanine-Induced Activation of NO System: New Perspectives in Memory-Related Disorders

Frontiers in Pharmacology, 2018
Mounting evidence suggests that the guanine-based purines stand out as key player in cell metabolism and in several models of neurodegenerative disorders, such as Parkinson’s and Alzheimer’s diseases.
Mariachiara Zuccarini, Mariachiara Zuccarini, Patricia Giuliani, Patricia Giuliani, Monica Frinchi, Giuseppa Mudò, Rosa Maria Serio, Natale Belluardo, Silvana Buccella, Silvana Buccella, Marzia Carluccio, Marzia Carluccio, Daniele F. Condorelli, Francesco Caciagli, Francesco Caciagli, Renata Ciccarelli, Renata Ciccarelli, Patrizia Di Iorio, Patrizia Di Iorio   +18 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Bioinformatic Analysis of Plasmodium berghei Hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGPRT): a Potential Therapeutic Target

, 2019
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGPRT) is essential for purine nucleotide and nucleic acid synthesis in the malaria parasite, Plasmodium spp.
Nahla O. M. Ali (6729740)
core   +1 more source