Results 171 to 180 of about 225,684 (400)

Recent Insights in Multi‐Target Drugs in Pharmacology and Medicinal Chemistry

ChemMedChem, EarlyView.
This review highlights the rationale behind multitarget drug design as a promising approach to address diseases with complex etiologies. By combining pharmacophore features from different single‐target drugs, multitarget compounds can interact with multiple biological targets simultaneously.
Sadık Hüseyin Cemali, Samet Poyraz, Samet Belveren, Senanur Taş, Mehmet Ali Tamer, Naciye Yaktubay Döndaş, H. Ali Döndaş, Jose Miguel Sansano   +7 more
wiley   +1 more source

The Inhibition of Succinoadenylate Kinosynthetase of Escherichia coli by Adenosine and Guanosine 5'-Monophosphates

, 1963
James Β. Wyngaarden, Roy A. Greenland
openalex   +1 more source

Inhibition of herpes virus by a new compound—acyclic guanosine [PDF]

, 1979
J. S. Oxford
openalex   +1 more source

Terahertz Raman Optical Activity Reveals Emergent Supramolecular Chirality in Mononucleotide G‐quadruplexes

Chemistry–Methods, EarlyView.
Self‐assembly of guanosine‐5′‐monophosphate into G‐quadruplexes induces a cation‐specific (sodium vs. potassium), intense terahertz Raman optical activity signal. The supramolecular helical arrangement gives rise to a distinct chiral vibrational signature in the low‐frequency region.
Štěpán Jílek, Josef Kapitán, Václav Profant   +2 more
wiley   +1 more source

Thermodynamic Data for the Secondary Phosphate Ionizations of Adenosine, Guanosine, Inosine, Cytidine, and Uridine Nucleotides and Triphosphate

, 1965
Roger C. Phillips, Sara Eisenberg, Philip George, Robert J. Rutman   +3 more
openalex   +1 more source

7-Methyl-guanosine and efficiency of RNA translation [PDF]

, 1976
Ding S. Shih, Ranjit Dasgupta, Paul Kaesberg   +2 more
openalex   +1 more source

Identification of Candidate Blood Biomarkers of Recombinant Human Erythropoietin Administration Using Targeted Polar Metabolomics by HILIC‐MS/MS

Drug Testing and Analysis, EarlyView.
Using targeted HILIC‐MS/MS metabolomics, inosine and hypoxanthine were identified as potential biomarkers of EPO administration. Their consistent and sensitive plasma responses highlight their promise for inclusion in the Athlete Biological Passport (ABP), warranting further investigation to enhance anti‐doping detection strategies. ABSTRACT Increasing
Olivier Salamin, Lejla Ramic, Raul Nicoli, Serge Rudaz, Davy Guillarme, Tiia Kuuranne   +5 more
wiley   +1 more source

Synthesis, H2S releasing properties, antiviral and antioxidant activities and acute cardiac effects of nucleoside 5′-dithioacetates

Scientific Reports
Hydrogen sulfide (H2S) is an endogenous gasotransmitter with cardioprotective and antiviral effects. In this work, new cysteine-selective nucleoside-H2S-donor hybrid molecules were prepared by conjugating nucleoside biomolecules with a thiol-activatable ...
Miklós Bege, Miklós Lovas, Dániel Priksz, Brigitta Bernát, Ilona Bereczki, Rasha Ghanem Kattoub, Richárd Kajtár, Simon Eskeif, Levente Novák, Jan Hodek, Jan Weber, Pál Herczegh, István Lekli, Anikó Borbás   +13 more
doaj   +1 more source

Increases of Guanosine 3′,5′-Monophosphate-related Enzymes in Kidneys of Developing Rats [PDF]

, 1978
Detlef Schlöndorff, Walter Trizna
openalex   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source