Results 171 to 180 of about 236,112 (356)

RNA m1A methyltransferase TRMT61A promotes colorectal tumorigenesis by enhancing ONECUT2 mRNA stability and is a potential therapeutic target

Cancer Communications, EarlyView.
Abstract Background The role of N1‐methyladenosine (m1A) in cancer is poorly understood. Here we explored the function of RNA methyltransferase TRNA methyltransferase 61A (TRMT61A) in colorectal cancer (CRC) and its potential as a therapeutic target. Methods RNA m1A levels were assessed through liquid chromatography‐mass spectrometry.
Xiaoting Zhang, Na Qin, Fenfen Ji, Hao Su, Haiyun Shang, Hongyan Chen, Dan Huang, Qing Li, Jing Ren, Weixin Liu, Yifei Wang, Wei Kang, Jiabin Wu, Chi‐Chun Wong, Zongwei Cai, Matthew Tak Vai Chan, William Ka Kei Wu, Jun Yu, Huarong Chen   +18 more
wiley   +1 more source

Effect of hypocalcemic protein P-MSY obtained from bovine parotid gland on the cyclic adenosine-5'-monophosphate and cyclic guanosine-5'-monophosphate contents of murine thymus and spleen cells.

, 1983
Hajimu Yamamoto, Ikukatsu Suzuki, Akira Mizutani   +2 more
openalex   +2 more sources

The Potential of Phytochemicals to Overcome Multidrug Resistance in Metastatic Melanoma

Chemistry &Biodiversity, EarlyView.
ABSTRACT Metastatic melanoma is the most lethal form of skin cancer, accounting for most skin cancer‐related deaths. Immunotherapies and targeted therapies have improved overall and progression‐free survival rates in metastatic melanoma patients. The effectiveness of these therapies decreases due to multidrug resistance (MDR).
Jacqueline Maphutha, Danielle Twilley, Mona Dawood, Thomas Efferth, Namrita Lall   +4 more
wiley   +1 more source

Synthesis, H2S releasing properties, antiviral and antioxidant activities and acute cardiac effects of nucleoside 5′-dithioacetates

Scientific Reports
Hydrogen sulfide (H2S) is an endogenous gasotransmitter with cardioprotective and antiviral effects. In this work, new cysteine-selective nucleoside-H2S-donor hybrid molecules were prepared by conjugating nucleoside biomolecules with a thiol-activatable ...
Miklós Bege, Miklós Lovas, Dániel Priksz, Brigitta Bernát, Ilona Bereczki, Rasha Ghanem Kattoub, Richárd Kajtár, Simon Eskeif, Levente Novák, Jan Hodek, Jan Weber, Pál Herczegh, István Lekli, Anikó Borbás   +13 more
doaj   +1 more source

Purification and general properties of guanosine 3':5'-monophosphate-dependent protein kinase from guinea pig fetal lung.

, 1976
J.F. Kuo, Wu‐Nan Kuo, Mikio Shoji, Craig W. Davis, Virginia L. Seery, Thomas E. Donnelly   +5 more
openalex   +1 more source

Immobilized Enzymes for ABO‐Independent Blood Cell Transfusions

ChemBioChem, EarlyView.
A method is developed to generate universal red blood cells and platelets using suitable glycosidases immobilized to polymethacrylate microparticles. This approach allows the efficient removal of the enzymes converting the A and B antigens before transfusion to avoid immune reactions and illustrates a promising method to counteract the demand for blood
Christina Möller, Fabian Pohlschröder, Jan Wesche, Paula Schmiade, Merle Baselau, Kristian Wende, Berenika Stloukalová, Dominique Böttcher, Andreas Greinacher, Uwe T. Bornscheuer, Henrik Terholsen, Konstanze Aurich   +11 more
wiley   +1 more source

Bimolecular interaction between MR121 and guanosine

, 2011
Ji-Ho Kim, Doose Sören, Hannes Neuweiler, Sauer Markus   +3 more
openalex   +1 more source

Nanogel‐Mediated Immunotherapy to Tackle Cancer and Inflammatory Diseases

ChemistryEurope, EarlyView.
Nanogels formed through self‐assembly, microemulsion, or precipitation polymerization method enable precise delivery of immunotherapeutic factors and immune cell targeting, thus effectively modulating immune responses. This review highlights recent advances in stimuli‐responsive nanogel design, underlying mechanisms, and their potentials to tackle ...
Ziwen Zhang, Jinxia Wang, Guang‐Zhi Jin, István Bányai, Dzmitry Shcharbin, Ivan Stoikov, Mingwu Shen, Xiangyang Shi   +7 more
wiley   +1 more source

Synthetic Cathepsin B Sensitive Adjuvant‐Peptide Conjugates to Target Intracellular Toll‐Like Receptors 7 and 8

ChemistryEurope, EarlyView.
Cathepsin B‐sensitive peptide–adjuvant conjugates are designed, synthesized, and evaluated to deliver an antigenic peptid and an adjuvant targeting Toll‐like receptors 7 and 8 (TLR7/8) to antigen presenting cells. The adjuvant is released by cathepsin B resulting in antigen presentation and TLR mediated T cell activation.
Marjolein M. E. Isendoorn, Giulia Castello, Nico J. Meeuwenoord, Martijn Verdoes, Jeroen D. C. Codée, Ferry Ossendorp, Dmitri V. Filippov   +6 more
wiley   +1 more source

Synthesis and turnover of basal level guanosine tetraphosphate in Escherichia coli.

, 1975
James D. Friesen, Niels P. Fiil, K. von Meyenburg   +2 more
openalex   +1 more source